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Interaction of Acute Transforming Retroviruses with Murine Hematopoietic Cells

  • J. H. Pierce
  • S. A. Aaronson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)

Abstract

There is emerging evidence that several retroviral onc gene products possess functional, structural, and amino acid sequence homology. Rous sarcoma virus (RSV), Abelson-murine leukemia virus (Abelson-MuLV), and Snyder-Thei1en feline sarcoma virus (ST-FeSV) code for related phosphoproteins that have associated tyrosine-specific protein kinase activity (Barbacid et al., 1 980; Witte et al., 1980; Reddy et al., 1983). BALB-, Harvey-, and Kirsten-murine sarcoma viruses (MSVs) are members of another family whose 21,000 dalton transforming proteins possess GDP binding and autophosphorylation activity (Shih et al., 1979; Andersen et al., 1981). Investigation of the diversity of hematopoietic target cells susceptible to neoplastic transformation by specific retroviruses might be expected to provide insights into the relationship of the differentiated state of a cell and its susceptibility to the action of a family of onc genes. As an approach to this question, we took advantage of We availability of hematopoietic cell transformation assay systems to analyze the array of cellular targets whose growth and differentiation could be altered by different retroviral onc genes.

Keywords

Terminal Deoxynucleotidyl Transferase Rous Sarcoma Virus Compact Coloni Lymphoid Progenitor Cell Murine Hematopoietic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andersen PR, Devare DG, Tronick SR, Ellis, RW, Aaronson, SA, Scolnick EM (1981) Generation of BALB-MuSV and Ha-MuSV by type C virus transduction of homologous transforming genes from different species. Cell 26: 129–134PubMedCrossRefGoogle Scholar
  2. Anderson SM, Scolnick EM (1983) Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus. J Virol 46: 594–605PubMedGoogle Scholar
  3. Barbacid M, Beemon K, Devare SG (1980) Origin and functional properties of the major gene product of the Snyder-Thei1 en strain of feline sarcoma virus. Proc Natl Acad Sci USA 77: 5158–5163PubMedCrossRefGoogle Scholar
  4. Bollum FT (1979) Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood 54: 1203–1215PubMedGoogle Scholar
  5. Durban EM, Boettiger D (1981) Differential effects of transforming avian RNA tumor viruses on avian macrophages. Proc Natl Acad Sci 78: 3600–3604PubMedCrossRefGoogle Scholar
  6. Hankins DW, Scolnick EM (1981) Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro. Cell 26: 91–97PubMedCrossRefGoogle Scholar
  7. Pierce JH, Aaronson SA (1982) BALB- and Harvey-murine sarcoma virus transformation of a novel lymphoid progenitor cell. J Exp Med 156: 873–887PubMedCrossRefGoogle Scholar
  8. Pierce JH, Aaronson SA (1983) In vitro transformation of murine pre-B lymphoid cells by Snyder-Thei1 en feline sarcoma virus. J Virol 46: 993–1002PubMedGoogle Scholar
  9. Pierce JH, Aaronson SA, Anderson SM (1984) Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc Natl Acad Sci USA (in press)Google Scholar
  10. Reddy E, Smith MJ, Srinivasan A (1983) Nucleotide sequence of Abelson murine leukemia virus genome: Structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity. Proc Natl Acad Sci 80: 3623–3627PubMedCrossRefGoogle Scholar
  11. Rosenberg N, Baltimore D (1976) A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med 143: 1453–1463PubMedCrossRefGoogle Scholar
  12. Scher CD, Scolnick EM, Siegler R (1975) Induction of erythroid leukemia by Harvey and Kirsten sarcoma viruses. Nature 256: 225PubMedCrossRefGoogle Scholar
  13. Shih TY, Weeks MO, Young HA, Scolnick EM (1979) p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature-sensitive for the maintenance of transformation. J Virol 31: 546–560PubMedGoogle Scholar
  14. Siden E, Baltimore D, Clark P, Rosenberg N (1979) Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell 16: 389–396PubMedCrossRefGoogle Scholar
  15. Whitlock CA, Witte ON (1981) Abelson virus infected cells can exhibit restricted in vitro growth and low oncogenic potential. J Virol 40: 577–584PubMedGoogle Scholar
  16. Witte ON, Dasgupta A, Baltimore D (1980) Abelson murine leukemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature 283: 826–831PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • J. H. Pierce
    • 1
  • S. A. Aaronson
    • 1
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA

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