Interaction of Acute Transforming Retroviruses with Murine Hematopoietic Cells

  • J. H. Pierce
  • S. A. Aaronson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)


There is emerging evidence that several retroviral onc gene products possess functional, structural, and amino acid sequence homology. Rous sarcoma virus (RSV), Abelson-murine leukemia virus (Abelson-MuLV), and Snyder-Thei1en feline sarcoma virus (ST-FeSV) code for related phosphoproteins that have associated tyrosine-specific protein kinase activity (Barbacid et al., 1 980; Witte et al., 1980; Reddy et al., 1983). BALB-, Harvey-, and Kirsten-murine sarcoma viruses (MSVs) are members of another family whose 21,000 dalton transforming proteins possess GDP binding and autophosphorylation activity (Shih et al., 1979; Andersen et al., 1981). Investigation of the diversity of hematopoietic target cells susceptible to neoplastic transformation by specific retroviruses might be expected to provide insights into the relationship of the differentiated state of a cell and its susceptibility to the action of a family of onc genes. As an approach to this question, we took advantage of We availability of hematopoietic cell transformation assay systems to analyze the array of cellular targets whose growth and differentiation could be altered by different retroviral onc genes.


Terminal Deoxynucleotidyl Transferase Rous Sarcoma Virus Compact Coloni Lymphoid Progenitor Cell Murine Hematopoietic Cell 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • J. H. Pierce
    • 1
  • S. A. Aaronson
    • 1
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA

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