Identification of a Transforming Virus from a Lymphoma of a Mouse Infected with a Wild Mouse Retrovirus
Cas-Br-M is a biologically-cloned ecotropic murine leukemia virus (MuLV) isolated from wild mice of the Lake Casitas region of California (1). This virus induces both hind limb paralysis and hematopoietic neoplasms when inoculated into newborn mice (2,3). The tumors of mice inoculated with Cas-Br-M are first evident at 18–30 weeks and include T- and B-cell lymphomas, lymphoblastic lymphomas, erythroleukemias, myelogenous leukemias and megakaryocytic leukemias (4). Cas-Br-M therefore appears to be unique among murine retroviruses in its ability to cause a wide spectrum of hematopoietic tumors. The mechanisms involved in generating this range of tumors are not known, however mink lung cell focus-inducing (MCF) MuLVs may play a role since these viruses appear rapidly in the tissues of Cas-Br-M infected mice (5).
KeywordsFormaldehyde Lymphoma EDTA Leukemia Agarose
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- 3.Gardner, M.B., Klement, V., Henderson, B.E., Casagrande, J., Bryant, M.L., Daugherty, M.F., Estes, J.D.: Lymphoma, paralysis, and oncornaviruses of wild mice. In: Tumors of Early Life in Man and Animals. Severi, L. (ed.), Perugia Quadrennial International Conferences on Cancer, Montelvce, Italy, 1978, pp. 343–356.Google Scholar
- 9.Morse, H.C. III, Chused, T.M., Boehm-Truitt, M., Mathieson, B.J., Sharrow, S.O., Hartley, J.W.: XenCSA: Cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia virus. J. Immunol. 122, 433–454 (1979).Google Scholar
- 16.Robins, T., Bister, K., Garon, C., Papas, T., Deusberg, P.: Structural relationship between a normal chicken DNA locus and the transforming gene of the avian acute leukemia virus MC29. J. Virol. 41, 63 5–642 (1982).Google Scholar