Identification of a Transforming Virus from a Lymphoma of a Mouse Infected with a Wild Mouse Retrovirus
Cas-Br-M is a biologically-cloned ecotropic murine leukemia virus (MuLV) isolated from wild mice of the Lake Casitas region of California (1). This virus induces both hind limb paralysis and hematopoietic neoplasms when inoculated into newborn mice (2,3). The tumors of mice inoculated with Cas-Br-M are first evident at 18–30 weeks and include T- and B-cell lymphomas, lymphoblastic lymphomas, erythroleukemias, myelogenous leukemias and megakaryocytic leukemias (4). Cas-Br-M therefore appears to be unique among murine retroviruses in its ability to cause a wide spectrum of hematopoietic tumors. The mechanisms involved in generating this range of tumors are not known, however mink lung cell focus-inducing (MCF) MuLVs may play a role since these viruses appear rapidly in the tissues of Cas-Br-M infected mice (5).
KeywordsLong Terminal Repeat Murine Leukemia Virus Wild Mouse Lymphoblastic Lymphoma Hematopoietic Tumor
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