Abstract
The normal heterogeneity of cells in the B lymphocyte lineage greatly complicates studies of the mechanisms involved in B cell maturation and function and of events that induce their neoplastic transformation. Until quite recently, the only homogeneous populations of B lineage cells available for these types of studies have been lymphomas and plasmacytomas with phenotypic and functional characteristics of normal B cells arrested at distinct maturational stages (1,2). Extrapolations of results obtained in these systems to normal B cells has been shown to be valid in many instances and, although they certainly have their limitations, transformed lines will continue to be useful for both phenotypic and genotypic characterizations of specific differentiative stages.
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Morse, H.C., Lamers, M.C., Rudikoff, E.K., Davidson, W.F. (1984). Characteristics of Continuous in vitro Lines of BALB/c and NZB B Cells. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_36
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DOI: https://doi.org/10.1007/978-3-642-69860-6_36
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