myc-Encoded Proteins of Chickens and Men

  • Robert N. Eisenman
  • Stephen R. Hann
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)

Abstract

Recent work from many laboratories has demonstrated that the chromosomal locus containing the myc oncogene is the site of an extraordinary number of rearrangements. These rearrangements take the form of translocations, amplifications, and retroviral insertions and examples have been found in chickens, mice, and humans. In addition, such alterations in the myc locus appear to be associated with neoplasias of primarily lymphoid origin although myc amplification has also been observed in human neuroendocrine tumors and small cell lung carcinomas (see other papers in this volume).

Keywords

Cellulose Lymphoma Leukemia Recombination Electrophoresis 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • Robert N. Eisenman
    • 1
  • Stephen R. Hann
    • 1
  1. 1.Division of Basic SciencesFred Hutchinson Cancer Research CenterSeattleUSA

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