Abstract
There is a large scale daily production of B lymphocytes within bone marrow of mammals, however until recently, little has been known about cellular interactions or humoral factors which normally regulate this process. Monoclonal antibodies to B lineage antigens of mice and humans now permit the detection and manipulation of B cell precursors which lack surface immunoglobulin. We have been using these with several culture techniques to identify factors which may be important in this process and have been particularly aided in our studies by materials from genetically defective animals and patients. The properties and possible target cells of two newly discovered cytokines will be summarized in this communication. An established tumor cell line is responsive to at least some of the factors which influence normal B cell precursors and it seems likely that a better understanding of such mechanisms will be instructive with respect to malignant cell proliferation and differentiation.
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© 1984 Springer-Verlag Berlin · Heidelberg
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Kincade, P.W. et al. (1984). Factors Affecting Normal and Malignant B Lymphocyte Precursors. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_20
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DOI: https://doi.org/10.1007/978-3-642-69860-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69862-0
Online ISBN: 978-3-642-69860-6
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