Abstract
WEHI-231, a murine cell line established from a B-cell lymphoma that arose in a BALB/c × NZB F1 hybrid mouse, was observed to stop growing in the presence of anti-immunoglobulin reagents (Ralph, 1979; Boyd and Schrader, 1981). This growth arrest is rapid and complete: virtually all of the cells stop growing in approximately 20 hours of culture with stoichiometric amounts of anti-Ig (DeFranco et al., 1982a). In contrast, most other B-cell lines grow fairly normally in the presence of anti-Ig. These results suggested that WEHI-231 would be an exceptional model system for studying genetic and biochemical aspects of antigen receptor-mediated regulation of B-cell growth.
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© 1984 Springer-Verlag Berlin · Heidelberg
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DeFranco, A.L. (1984). Growth Regulation of a B-Cell Lymphoma via the Antigen Receptor. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_17
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DOI: https://doi.org/10.1007/978-3-642-69860-6_17
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