Interleukin 3 Dependent Retrovirus Induced Lymphomas: Loss of the Ability to Terminally Differentiate in Response to Differentiation Factors
The mechanisms by which murine retroviruses induce lymphomas are largely unknown. A number of requirements have been defined which play an essential role. In Moloney leukemia virus (MoLV) induced leukemia, one potential component is an immune response (Lee and Ihle, 1981; Lee and Ihle, 1981). This has been speculated to be due to a requirement to generate an appropriate target cell population, which is accomplished by viral antigen-induced production of several lymphokines by antigen-specific helper T cells. These lymphokines subsequently induce the proliferation and differentiation of a variety of cell types. As a consequence of the acute viremia and the presence of antigen-specific helper T cells, the frequency of cells proliferating to T cell-derived lymphokines is 50- to 200-fold higher than in control mice. It is from this expanded population that the lymphomas ultimately arise (Pepersack et al., 1980).
KeywordsMyelogenous Leukemia Lymphoma Cell Line Thymic Lymphoma Moloney Leukemia Virus Hematopoietic Stem Cell Differentiation
Unable to display preview. Download preview PDF.
- Ihle JN, Keller J, Oroszlan S, Henderson L, Copeland T, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B (1983) Biological properties of homogeneous interleukin 3: I. Demonstration of WEHI-3 growth factor activity, P-cell stimulating factor activity, colony stimulating factor activity and histamine producing cell stimulating factor activity. J. Immunol. 131: 282–287.PubMedGoogle Scholar
- Ihle JN (1984) Biochemical and biological properties of interleukin 3. Clinical Immunology Newsletter. In press.Google Scholar
- Ihle JN (1984) Biochemical and biological properties of interleukin 3: A lymphokine mediating the differentiation of a lineage of cells which includes prothymocytes and mast-like cells. Contemporary Topics in Molecular Immunology. FP Inman (ed.) Plenum Press, New York. In press.Google Scholar