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Abstract

Organic solvents are volatile organic liquids which dissolve lipids and high-molecular-weight compounds. Liposolubility determines both toxicokinetics and health risk. The effects on health are largely nonspecific, i.e., more or less common to all solvents: defatting of skin, irritation of mucosae, and depression of the central nervous system. The effects (acute, reversible) may occur in direct relation to exposure or after moderate, long-term exposure, and may be slowly reversible or lead to more or less permanent health impairment (e. g., organic psychosyndrome).

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References

  • Bagnell PC, Ellenberger HA (1977) Obstructive jaundice due to a chlorinated hydrocarbon in breast milk. Can Med Assoc J 117: 1047–1048

    PubMed  CAS  Google Scholar 

  • Blair A, Decoufle P, Grauman D (1979) Causes of death among laundry and dry cleaning workers. Am J Public Health 69: 508–511

    Article  PubMed  CAS  Google Scholar 

  • Britanov NG (1979) Effect of noise and acetone on female workers in acetate and Polyvinylchloride fiber factories (in Russian). Gig Tr Prof Zabol 24 [12]: 15–19

    Google Scholar 

  • Butarewicz L, Gosk S, Gluszczowa M (1969) Examination of the state of health of women workers in the leather industry, especially from the gynaecological point of view. Med Pr 20: 137–148

    Google Scholar 

  • Funes-Cravioto F, Kolmodin-Hedman B, Lindsten J, Nordenskjöld M, Zapata-Gayon C, Lambert B, Norberg E, Olin R (1977) Chromosome aberrations and sister-chromatid exchange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers. Lancet II: 322–325

    Article  Google Scholar 

  • Gold EB, Diener MD, Szklo M (1982) Parental occupation and cancer in children. JOM 24: 578–584

    Article  PubMed  CAS  Google Scholar 

  • Helmer KJ (1944) Accumulated cases of chronic benzene poisoning in the rubber industry. Acta Med Scand 118: 354–375

    Article  Google Scholar 

  • Holmberg PC (1979) Central-nervous-system defects in children born to mothers exposed to organic solvents during pregnancy. Lancet II: 177–179

    Article  Google Scholar 

  • Holmberg PC, Kurppa K (1982) An epidemiologic approach to the study of possible teratogenic effects of chemical and physical environments. Scand J Work Environ Health [Suppl 1] 8: 89–91

    PubMed  Google Scholar 

  • Holmberg PC, Nurminen M (1980) Congenital defects of the central nervous system and occupational factors during pregnancy: a case-referent study. Am J Ind Med 1: 167–176

    Article  PubMed  CAS  Google Scholar 

  • Holmberg PC, Hernberg S, Kurppa K, Rantala K (1982) Oral clefts and organic solvent exposure during pregnancy. Int Arch Occup Environ Health 50: 371–376

    Article  PubMed  CAS  Google Scholar 

  • Izmerov NF, Sanockij IV, Grodeckaja NS, Fomenko VM (1978) Der Vergleich epidemiologischer und experimenteller Materialien bei der Untersuchung der Einwirkung industrieller Lösungsmittel auf die Arbeiter. Z Gesamte Hyg 24: 672–678

    PubMed  CAS  Google Scholar 

  • Katz RM, Jowett D (1981) Female laundry and dry cleaning workers in Wisconsin: a mortality analysis. Am J Public Health 71: 305–307

    Article  PubMed  CAS  Google Scholar 

  • Kucera J (1968) Exposure to fat solvents; a possible cause of sacral agenesis in man. J Pediatr 72:857–859

    Article  PubMed  CAS  Google Scholar 

  • Lob M (1976) Danger from benzene in laboratories? Workshop on benzene, Paris pp 9–11

    Google Scholar 

  • Maroni M, Bulgheroni C, Cassitto G, Merluzzi F, Gilioli R, Foa V (1977) A clinical, neurophysiological and behavioral study of female workers exposed to 1,1,1,-trichloroethane. Scand J Work Environ Health 3: 16–22

    Article  PubMed  CAS  Google Scholar 

  • Matsushita TM, Arimatsu Y, Ueda A, Satoh K, Nomura S (1975) Hematological and neuromuscular response of workers exposed to low concentration of toluene vapor. Ind Health 13: 115–121

    Article  CAS  Google Scholar 

  • Meklman MA, Schreiner CA, Mackerer CR (1980) Current status of benzene teratology: a brief review. J Environ Pathol Toxicol 4: 123–131

    Google Scholar 

  • Michon S (1965) Disturbances of menstruation in women working in an atmosphere polluted with aromatic hydrocarbons (in Polish). Pol Tyg Lek 20: 1648–1649 (Abstract)

    Google Scholar 

  • NIOSH (1974) Occupational exposure to benzene. HEW publ no (NIOSH) 74–137 US DHEW, Cincinnati, 137

    Google Scholar 

  • NIOSH (1975) Occupational exposure to xylene. HEW publ no (NIOSH) 75–168 US DHEW, Cincinnati, 168

    Google Scholar 

  • NIOSH (1976) Occupational exposure to ethylene dichloride (1, 2-dichloroethane). HEW publ no (NIOSH) 76–139 US DHEW, Cincinnati, 158

    Google Scholar 

  • Pellizari ED, Hartwell TD, Harris BSH, Waddell RD, Whitaker DA, Erickson MD (1982) Purgeable organic compounds in mothers’ milk. Bull Environ Contam Toxicol 28: 322–328

    Article  Google Scholar 

  • Postolache V (1974) Subjective signs in the course of occupational exposure to low concentrations of organic solvents (in Rumanian). Igiena 23: 265–272 (abstract)

    Google Scholar 

  • Sato A, Nakajima T, Fujiwara Y, Murayama N (1975) Kinetic studies on sex difference in susceptibility to chronic benzene intoxication with special reference to body fat content. Br J Ind Med 32: 321–328

    PubMed  CAS  Google Scholar 

  • Seppäläinen AH, Lindstrom K, Martelin T (1980) Neurophysiological and psychological picture of solvent poisoning. Am J Ind Med 1: 31–42

    Article  PubMed  Google Scholar 

  • Sobczyk W, Siedlecka B, Gajewska Z, Horyd W, de Mezer O (1977) EEG recordings in workers exposed to benzene compounds (in Polish). Med Pr 24: 272–283

    Google Scholar 

  • Sykes JF, Klein AK (1957) Chloro-organic residues in milk of cows orally administered ethylene dichloride. J Assoc Off Agric Chem 40: 203–209

    CAS  Google Scholar 

  • Syrovadko ON (1977) Working conditions and health of women working with organosilicone lacquers containing toluene (in Russian). Gig Tr Prof Zabol 21 [12]: 15–19

    Google Scholar 

  • Syrovadko ON, Malysheva ZV (1977) Work conditions and their influence on some specific functions of women engaged in the manufacture of enamel-insulated wires (in Russian). Gig Tr Prof Zabol 21 [4]: 25–28 (abstract)

    Google Scholar 

  • Syrovadko ON, Skormin VF, Pronkova EN, Sorkina S, Izyumova AS, Gribova IA, Popova AF (1973) Effect of working conditions on the health and some specific functions in female workers exposed to white spirit (in Russian). Gig Tr Prof Zabol 17 [6]: 5–8

    PubMed  CAS  Google Scholar 

  • Toxic Substances Control Act (TSCA) (1978) New TSC A 8 (c) submission on benzene shows fetotoxic effects at 10 ppm. Occup. Saf. Hlth Rep. 8: 1222

    Google Scholar 

  • Triebig G, Burkhardt K (1978) Arbeitsmedizinische Untersuchungen bei beruflicher Belastung mit dem Halogen-Kohlenwasserstoff 1, l,2-trichlor-l,2,2-trifluoräthan. Int Arch Occup Environ Health 42: 129–135

    Article  PubMed  CAS  Google Scholar 

  • Urusova TP (1953) About a possibility of dichloro-ethane absorption into milk of nursing women when contacted under industrial conditions (in Russian). Gig Sanit 18 [3]: 36–37

    Google Scholar 

  • van Raalte HGS, Grasso P (1982) Hematological, myelotoxic, carcinogenic and leukemogenic effects of benzene. Regul Toxical Pharmacol 2: 153–176

    Article  Google Scholar 

  • Watanabe T, Endo A, Kato Y, Shima S, Watanabe T, Ikeda M (1980) Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers. Int Arch Occup Environ Health 46: 31–41

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization (WHO) (1981) Recommended health-based limits in occupational exposure to selected organic solvents. WHO Technical Report Series no. 664

    Google Scholar 

  • Zack M, Cannon S, Loyd D, Heath CW, Falletta JM, Jones B, Housworth J, Crowley S (1980) Cancer in children of parents exposed to hydrocarbon-related industries and occupations. Am J Epidemiol 111: 329–336

    PubMed  CAS  Google Scholar 

  • Zielinski A (1973) General health state of women professionally exposed to trichloroethylene (“tri”) vapors (in Polish). Med Pr 24: 263–277

    CAS  Google Scholar 

Download references

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© 1984 Springer-Verlag Berlin Heidelberg

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Zielhuis, R.L., Stijkel, A., Verberk, M.M., van de Poel-Bot, M. (1984). Organic Solvents. In: Health Risks to Female Workers in Occupational Exposure to Chemical Agents. International Archives of Occupational and Environmental Health Supplement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69850-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-69850-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

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