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Antibiotic-Resistant Microorganisms

  • A. M. R. MacKenzie
Conference paper

Abstract

Microorganisms may be resistant to antibiotics by one of four basic mechanisms:
  1. 1)

    they may synthesize enzymes that inactivate antibiotics;

     
  2. 2)

    target sites on the microorganisms may be resistant to antibiotic binding;

     
  3. 3)

    they may become resistant to particular antibiotics by the development of metabolic pathways which bypass the site of the antibiotic’s action;

     
  4. 4)

    they may modify their inner or outer membrane to prevent the penetration of the antibiotic to the microbial target site.

     

Keywords

Staphylococcus Aureus Fusidic Acid Methicillin Resistance Aureus Strain Tolerant Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Acar, J.F., Courvalin, P., and Chabbert, Y.A.: Methicillin resistant staphylococcaemia: Bacteriological failure of treatment with cephalosporins. Antimicrob. Agents Chemother. 14, 280, 1978.Google Scholar
  2. 2.
    Amirak, I.D., Li, A.K.C., Williams, R.J., and Noone, P.: A fatal infection caused by methicillin resistant Staphylococcus aureus acquiring resistance to gentamicin and fusidic acid during therapy. J. Infect. 3, 50, 1981.PubMedCrossRefGoogle Scholar
  3. 3.
    Archer, G.L.: Antimicrobial susceptibility and selection of resistance among Staphylococcus epidermidis isolates recovered from patients with infections of indwelling foreign devices. Antimicrob. Agents Chemother. 14, 353, 1978.PubMedGoogle Scholar
  4. 4.
    Denny, A.E., Peterson, L.R., Gerding, D.N., and Hall, W.M.: Serious staphylococcal infections with strains tolerant to bactericidal antibiotics. Arch. Int. Med. 139, 1026, 1979.CrossRefGoogle Scholar
  5. 5.
    Kaye, D.: The clinical significance of tolerance to Staphylococcus aureus. Ann. Int. Med. 93, 924, 1980.PubMedGoogle Scholar
  6. 6.
    Laverdière, M., Peterson, P.K., Verhoef, J., Williams, D.N., and Sabath, L.D.: In vitro activity of cephalosporins against methicillin resistant, coagulase-negative staphylococci. J. Infect. Dis. 137, 245, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Lorian, V.: Antibiotics in Laboratory Medicine. Williams & Williams, 1980, p. 451.Google Scholar
  8. 8.
    Marks, M.I.: Antibiotic therapy of serious Haemophilus infections: a continuing problem. J. Pediat. 98, 910, 1981.PubMedCrossRefGoogle Scholar
  9. 9.
    Myers, J.P., and Linnemann, C.C.: Bacteremia due to methicillin resistant Staphylococcus aureus. J. Infect. Dis. 145, 532, 1982.PubMedCrossRefGoogle Scholar
  10. 10.
    Patterson, J.R., and Mansell, P.E.: Fucidin resistant staphylococci in current hospital practice. J. Med. Microbiol. 6, 235, 1973.CrossRefGoogle Scholar
  11. 11.
    Svenungsson, B., Kalin, M., and Lingren, L.G.: Therapeutic failure in pneumonia caused by a tolerant strain of Staphylococcus aureus. Scand. J. Infect. Dis. 14, 309, 1982.PubMedGoogle Scholar
  12. 12.
    Wenzel, R.P.: The emergence of methicillin resistant Staphylococcus aureus. Ann. Int. Med. 97, 440, 1982.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • A. M. R. MacKenzie

There are no affiliations available

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