Caffeine pp 77-85 | Cite as

The Cardiovascular Effects of Caffeine

  • D. Robertson
  • P. W. Curatolo


The effect of caffeine on the heart and blood vessels has attracted the attention of investigators for more than 100 years. The earliest studies are reviewed in some detail by Bock (1920) and Eichler (1938). In the second edition of his monograph on caffeine, Eichler (1976) reviewed the literature on the cardiovascular effects of caffeine up to the year 1974. Much of the available data comes from animal studies. In some cases the human pharmacology of caffeine has been inferred from studies with theophylline. The first part of this chapter will deal with in vitro and animal studies. In the last part of the chapter the effects of the drug in man will be treated.


Ischemic Heart Disease Adenosine Receptor Plasma Renin Activity Coffee Consumption Coffee Drinking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ammon HPT, Estler CJ (1969) The influence of caffeine on carbohydrate and lipid metabolism in alloxan-diabetic mice. Med Exp 19: 161–169PubMedGoogle Scholar
  2. Anrep GV, Stacey RF (1927) Comparative effect of various drugs upon the coronary circulation. J Physiol 64: 187–192PubMedGoogle Scholar
  3. Beavo JA, Rogers NL, Crofford OB, Baird CE, Hardman JG, Sutherland EW, Newman EV (1971) Effects of phosphodiesterase inhibitors on cyclic AMP levels and on lipolysis. Ann NY Acad Sci 185: 129–136PubMedCrossRefGoogle Scholar
  4. Bellet S, Horstman E, Roman LR, de Guzman NT, Kostis JB (1972) Effect of caffeine on the ventricular fibrillation threshold in normal dogs with acute myocardial infarction. Am Heart J 84: 215–227PubMedCrossRefGoogle Scholar
  5. Berne RM, Rubio R (1974) Regulation of coronary blood flow. Adv Cardiol 12: 303–317PubMedGoogle Scholar
  6. Bock J (1920) Die Purinderivate. In: Heffter A, Heubner W (eds) Handbuch der experimentellen Pharmakologie, vol 2/1. Springer, Berlin, pp 508–598Google Scholar
  7. Bock J, Buchholtz J (1920) Henriques-Methode über das Minutenvolumen des Herzens beim Hunde und über den Einfluß des Coffeins auf die Größe des Minutenvolumens. Arch Exp Pharmacol 88: 192–215CrossRefGoogle Scholar
  8. Bondaryov MG (1967) The influence of analeptic drugs on the pontine vasomotor center. Prog Brain Res 20: 171–186CrossRefGoogle Scholar
  9. Boston Collaborative Drug Surveillance Program (1972) Coffee drinking and acute myocardial infarction. Lancet 2: 1278–1281Google Scholar
  10. Boublik JH, Quinn MJ, Clements JA, Herington AC, Wynn KN, Funder JW (1983) Coffee contains potent opiate receptor binding activity. Nature 301: 246–248PubMedCrossRefGoogle Scholar
  11. Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24: 509–581PubMedGoogle Scholar
  12. Chapman RA, Miller DJ (1971) The action of caffeine on frog myocardial contractility. J Physiol (Lond)217: 64P–66PGoogle Scholar
  13. Chytkowski A, Panczenko B, Krupinska J, Bieron K, Zmuda A (1970) Circulatory action of 7(beta-methyl,thio-ethyl)-theophylline. Diss Pharm Pharmacol 22: 199–207Google Scholar
  14. Curatolo PW, Robertson D (1983) The health consequences of caffeine. Ann Intern Med 98: 641–653PubMedGoogle Scholar
  15. Daly JW, Bruns RF, Snyder SH (1981) Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines. Life Sci 28: 2083–2097PubMedCrossRefGoogle Scholar
  16. Dawber TR, Kannel WB, Gordon T (1974) Coffee and cardiovascular disease: observations from the Framingham study. N Engl J Med 291: 871–874PubMedCrossRefGoogle Scholar
  17. De Gubareff T, Sleator W Jr (1965) Effects of caffeine on mammalian atrial muscle and its interaction with adenosine and calcium. J Pharmacol Exp Ther 148: 202–214Google Scholar
  18. Dobmeyer DJ, Stine RA, Leier CV, Greenberg R, Schall S F (1983) The arrhythmogenic effects of caffeine in human beings. N Engl J Med 308: 814–816PubMedCrossRefGoogle Scholar
  19. Eichler O (ed) (1938) Kaffee und Coffein. Springer, BerlinGoogle Scholar
  20. Eichler O (ed) (1976) Kaffee und Coffein, 2nd edn. Springer, Berlin Heidelberg New YorkGoogle Scholar
  21. Flaum E, Rössler R (1933) Über die Herzwirkung der Purinkörper. Klin Wochenschr 11: 1489CrossRefGoogle Scholar
  22. Fredholm BB, Persson CGA (1982) Xanthine derivatives as adenosine receptor antagonists. Eur J Pharmacol 81: 673–676PubMedCrossRefGoogle Scholar
  23. Goldberg MR, Curatolo PW, Tung C-S, Robertson D (1982) Caffeine reduces beta-adrenoceptor density in rat cerebral cortex. Neurosci Lett 31: 47–53PubMedCrossRefGoogle Scholar
  24. Gould L, Venkataraman K, Goswami M, Gomprecht RF (1973) The cardiac effects of coffee. An-giology 24: 455–463Google Scholar
  25. Graboys TB, Lown B (1983) Coffee, arrhythmias, and common sense. N Engl J Med 308: 835–837PubMedCrossRefGoogle Scholar
  26. Grollmann A (1930) The action of alcohol, caffeine, and tobacco on the cardiac output (and its related functions) of normal man. J Pharmacol Exp Ther 39: 313–327Google Scholar
  27. Guthrie JR, Naylor WG (1967) Interaction between caffeine and adenosine on calcium exchangeability in mammalian atria. Arch Int Pharmacodyn 170: 249–255PubMedGoogle Scholar
  28. Hahn F (1941) Vergleichende Untersuchungen über die Krampf- und Blutdruckwirkung verschiedener Analeptica. Arch Exp Pathol Pharmacol 198: 491–508CrossRefGoogle Scholar
  29. Hennekens CH, Drolette ME, Jesse MF, Davies JE, Hutchinson GB (1976) Coffee drinking and death due to coronary heart disease. N Engl J Med 294: 633–636PubMedCrossRefGoogle Scholar
  30. Heyden S, Tyroler HA, Heiss G, Harnes CG, Bartel A (1978) Coffee consumption and mortality: total mortality, stroke mortality, and coronary heart disease mortality. Arch Intern Med 138: 1472–1475PubMedCrossRefGoogle Scholar
  31. Horst K, Wilson RJ, Smith RG (1936) The effect of coffee and decaffeinated coffee on oxygen consumption, pulse rate and blood pressure. J Pharmacol Exp Ther 58: 294–304Google Scholar
  32. Jick H, Miettinen OS, Neff RK, Shapiro S, Heinonen OP, Slone D (1973) Coffee and myocardial infarction. N Engl J Med 289: 63–67PubMedCrossRefGoogle Scholar
  33. Kalsner S (1971) Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips. Br J Pharmacol 43: 379–388PubMedGoogle Scholar
  34. Kannel WB, Dawber TR (1973) Coffee and coronary disease (Editorial). N Engl J Med 289: 100–101PubMedCrossRefGoogle Scholar
  35. Kimoto Y, Saito M, Goto M (1972) Effects of caffeine on the membrane potentials, membrane currents and contractility of the bullfrog atrium. Jap J Physiol 22: 225–238CrossRefGoogle Scholar
  36. Klatsky AL, Friedman GD, Siegelaub AB (1973) Coffee drinking prior to acute myocardial infarction: results from the Kaiser-Permanente epidemiological study of myocardial infarction. JAMA 226: 540–543PubMedCrossRefGoogle Scholar
  37. Krop ST (1944) The influence of heart stimulants on the contraction of isolated mammalian cardiac muscle. J Pharmacol 82: 48–62Google Scholar
  38. Murray SS, Bjelke E, Gibson RW, Schuman LM (1981) Coffee consumption and mortality from ischemic heart disease and other causes: results from the Lutheran Brotherhood Study, 1966–1978. Am J Epidemiol 113: 661–667PubMedGoogle Scholar
  39. Paul O, Leper MH, Phelan WH, Dupertuis GW, MacMillan A, McKean H, Park H (1963) A longitudinal study of coronary heart disease. Circulation 28: 20–31PubMedGoogle Scholar
  40. Paul O, MacMillan A, McKean H, Park H (1968) Sucrose intake and coronary heart disease. Lancet 2: 1049–1051PubMedCrossRefGoogle Scholar
  41. Pilcher C, Wilson CP, Harrison TR (1927) The action of drugs on cardiac output. Am Heart J 2: 618–630CrossRefGoogle Scholar
  42. Polonowski M, Donzelot E, Briskas S, Doliopoulos T (1952) The comparative effects of coffee and soluble extracts of coffee on normal persons and on cardiacs. Cardiología 21: 809–816CrossRefGoogle Scholar
  43. Prineas RJ, Jacobs DR, Crow RS, Blackburn H (1980) Coffee, tea and VPB. J Chronic Dis 33: 67–72PubMedCrossRefGoogle Scholar
  44. Raff WK (1971) Wirkung des Coffeins auf Herz und Kreislauf. Arzneimittelforsch 21: 1177–1179PubMedGoogle Scholar
  45. Rall TW (1980) The xanthines. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 6th edn. Macmillan, New York, pp 592–607Google Scholar
  46. Robertson D, Frolich JC, Carr RK, Watson JT, Hollifield JW, Shand DG, Oates JA (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298: 181–186PubMedCrossRefGoogle Scholar
  47. Robertson D, Wade D, Workman R, Woosley RL, Oates JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67: 1111–1117PubMedCrossRefGoogle Scholar
  48. Robertson D, Wade D, Smith WB (to be published) Caffeine and hypertension Rosenberg I, Stone D, Shapiro K, Kaufman DW, Stolley PD, Miettinen OS (1980) Coffee drinking and myocardial infarction in young women. Am J Epidemiol 111: 675–681Google Scholar
  49. Sollman T, Pilcher JD (1911) The actions of caffeine on the mammalian circulation. J Pharmacol Exp Ther 3: 19–92Google Scholar
  50. Starr I, Gamble CJ, Margolies A (1937) A clinical study of the action of 10 commonly used drugs on cardiac output, work, and size: on respiration, on metabolic rate, and on the electrocardiogram. J Clin Invest 16: 799–823PubMedCrossRefGoogle Scholar
  51. Strubelt O, Siegers C-P (1968) Die Beteiligung endogener Catecholamine an den Wirkungen des Kaffees auf Energieumsatz und Herzfrequenz. Arzneimittelforsch 18: 1278–1281PubMedGoogle Scholar
  52. Tibblin G, Wilhelmsen L, Werko L (1975) Risk factors for myocardial infarction and death due to ischemic heart disease and other causes. Am J Cardiol 35: 514–522PubMedCrossRefGoogle Scholar
  53. Vittorio S (1923) Action of caffeine on the frequency of the cardiac pulse (in Italian) Arch Int Pharmacodyn 27: 265–282Google Scholar
  54. Vitzthum OG (1975) Chemie und Bearbeitung des Kaffees. In: Eichler O (ed) Kaffee und Coffein. Springer, Berlin Heidelberg New YorkGoogle Scholar
  55. von Borstel R, Wurtman RJ, Conlay LA (1983) Chronic caffeine consumption potentiates the hypotensive action of circulating adenosine. Life Sci 32: 1151–1158CrossRefGoogle Scholar
  56. Walker WJ, Gregoratos MG (1967) Myocardial infarction in young men. Am J Cardiol 19: 339–343PubMedCrossRefGoogle Scholar
  57. Wilhelmsen L, Tibblin G, Elmfeldt D, Wedel H, Werko L (1977) Coffee consumption and coronary heart disease in middle-aged Swedish men. Acta Med Scand 201: 547–552PubMedCrossRefGoogle Scholar
  58. Yano K, Rhoads GG, Kagan A (1977) Coffee, alcohol, and risk of coronary heart disease among Japanese men living in Hawaii. N Engl J Med 297: 405–409PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • D. Robertson
  • P. W. Curatolo

There are no affiliations available

Personalised recommendations