Abstract
Since Köhler and Milstein (1975) perfected the hybridroma technique, it has been possible to produce monoclonal antibodies (Mo Abs) which react against antigens of the human MHC. This technology allowed the production of some polymorphic reagents, of which 54 HLA-A and B Mo Abs were selected for the Ninth Workshop; 49 of these had clear HLA-A or B specificity assigned by the submitting laboratory. Two analyses were carried out. The first used 5000 unrelated individuals including 3000 Caucasoids, 1500 Japanese, and 500 Negroes. The second was performed on data from all British laboratories, selected European laboratories (ARN, BAR, FAU, FER, GAN, JEA, VIV, IT 1, CRB, CON, MTT, MEN, SAV), South African laboratories (DUT, HAM), and Japanese laboratories (TOK, KSH, OKO, SAS).
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References
Berger AE, Davis JE, Cresswell P (1982) Monoclonal anti-body to HLA-A3. Hybridoma 1: 87–90
Bourel D, Fauchet R, Genetet B, Merdrignac G, Hurez D (1982) A monoclonal antibody to HLA-A3 allo-antigen. Immunol Letters 5: 233–237
Trabace S, Mazzilli MC, Cascino I, Lulli SP, Costanzi S, Costanzi PS, Gandini E (1984) A mouse monoclonal anti-body detecting the allospecificity HLA-A3. Tissue Antigens 23: 12–16
Belvedere M, Richiardi P, Luciani G, Curtoni ES (1980) Crossreactions among HLA-A antigens particularly focused on HLA-A28. In: Terasaki PI (ed) Histocompatibility testing 1980. UCLA, Los Angeles, p 751
Kennedy LJ, Bodmer JG (1983) A2 variants including A2/A28 (a new A-locus antigen) defined by monoclonal antibodies ( MCA ). Ninth Workshop Newsletter V: 1–3
Miiller C, Liangru S, Schneider M, Ziegler A, Wernet P (1983) A cytotoxic monoclonal IgM antibody (Tü1O1) directed against an antigenic determinant shared between the HLA-A allospecificities A2 and A28. Hum Immunol 6: 189–197
Grumet FC, Fendly VM, Fish L, Foung S, Engleman EG (1982) A monoclonal antibody (B27M2) subdividing HLA-B27. Hum Immunol 5: 61–72
Sato K, Kusama M, Yamashita Y, Nose Y, Sukegawa T, Tsuji K (1984) Possible supertypic HLA-A antigen detected by monoclonal antibodies in Japanese. Ninth Work-shop Newsletter 6: 26
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© 1984 Springer-Verlag Berlin Heidelberg
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Fauchet, R. et al. (1984). HLA-A, B, C Monoclonal Antibodies. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_91
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DOI: https://doi.org/10.1007/978-3-642-69770-8_91
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69772-2
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