HLA-A, B, C Monoclonal Antibodies
Since Köhler and Milstein (1975) perfected the hybridroma technique, it has been possible to produce monoclonal antibodies (Mo Abs) which react against antigens of the human MHC. This technology allowed the production of some polymorphic reagents, of which 54 HLA-A and B Mo Abs were selected for the Ninth Workshop; 49 of these had clear HLA-A or B specificity assigned by the submitting laboratory. Two analyses were carried out. The first used 5000 unrelated individuals including 3000 Caucasoids, 1500 Japanese, and 500 Negroes. The second was performed on data from all British laboratories, selected European laboratories (ARN, BAR, FAU, FER, GAN, JEA, VIV, IT 1, CRB, CON, MTT, MEN, SAV), South African laboratories (DUT, HAM), and Japanese laboratories (TOK, KSH, OKO, SAS).
KeywordsReaction Frequency Imperial Cancer Research Fund Japanese Laboratory British Laboratory Histocompatibility Testing
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