Abstract
The structure of the HLA-D region has been enormously clarified by the results of recent gene cloning studies [1–4]. These results, when combined with those of cellular responses, serology and immunoprecipitation, lead to the suggested genetic complement and arrangement shown in Fig. 1.
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References
Auffray C, Lillie JW, Arnot C, Grossberger D, Kappes D, Strominger JL (1983) Isotopic and allotypic variation of human class II histocompatibility antigen a chain genes. Nature 308: 327 - 333
Larhammar D, Hyldig-Nielsen JJ, Servenius B, An- dersson G, Rask L, Peterson PA (1983) Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DCβ gene. Proc Natl Acad Sci USA 80: 7313–7317
Long EO, Wake CT, Gorski J, Mach B (1983) Complete sequence of an HLA-DRβ chain decuded from a cDNA clone and identification of multiple non-allelic DRβ chain genes. EMBO J 2: 389–394
Spielman RS, Lee J, Bodmer WF, Bodmer JG, Trows- dale J (1984) Six HLA-Da chain genes on human chromosome 6: polymorphisms and associations of DCα-related sequences with DR types. Proc Natl Acad Sci USA 81: 3461–3465
Kaufman JF, Auffray C, Korman AJ, Shackelford DA, Strominger J (1984) The class II molecules of the human and murine major histocompatibility complex. Cell 36: 1–13
Hurley CK, Giles RC, Nunez G, DrMars R, Nadler L, Winchester R, Statsny P, Capra JD (1984) Molecular localization of human class II MT2 and MT3 determinants. J Exp Med 160: 472–493
Suzuki M, Maeda H, Mukai R, Yabe T, Hamaguchi U (1983) Identification of the MT3 molecule using two- dimensional gel electrophoresis and alloantisera. Immunogenetics 18: 575–583
Jones PP, Murphy DB, Hewgill D, McDevitt HO (1978) Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates. Mol Immunol 16: 51–60
Charron DJ, McDevitt HO (1979) Analysis of HLA-D region associated molecules with monoclonal antibody. Proc Natl Acad Sci USA 79: 6567–6571
Rudd CE, Bodmer JG, Bodmer WF, Crumpton MJ (1984) HLA-D region antigen associated invariant poly-peptides as revealed by 2-D gel analysis: glycosylation and structural interrelationships. J Biol Chem (in press)
Strubin M, Mach B, Long EO (1984) The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity. EMBO J 3: 869–872
Owen MJ, Kissonerghis AM, Lodish HF, Crumpton MJ (1981) Biosynthesis and maturation of HLA-DR antigens in vivo. J Biol Chem 256: 8987–8993
Shackelford DA, Mann D, van Rood JJ, Ferrara GB, Strominger JL (1981) Human B-cell alloantigens DC1, MT1 and LB 12 are identical to each other but distinct from the HLA-DR antigen. Proc Natl Acad Sci USA 78: 4566–4590
de Kretser TA, Crumpton MJ, Bodmer JG, Bodmer WF (1982) Two-dimensional gel analysis of the polypeptides precipitated by a polymorphic HLA-DR 1,2,w6 mono-clonal antibody: evidence for a third locus. Eur J Immunol 12: 600–606
de Kretser TA, Crumpton MJ, Bodmer JG, Bodmer WF (1983) Biochemical analysis of the polymorphism of three HLA-D region antigens. Mol Biol Med 1: 59–76
Adams TE, Bodmer JG, Bodmer WF (1983) Production and characterisation of monoclonal antibodies recognising the a-chain subunits of human la alloantigens. Immunology 50: 613–624
Lampson LA, Levy R (1980) Two populations of la-like molecules on a human B cell line. J Immunol 125: 293–299
Quaranta V, Indiveri F, Glassy MC, Ng A, Russo C, Molinaro GA, Pellegrino MA, Ferrone S (1980) Serological, functional, and immunochemical characterization of a monoclonal antibody (MoAb Q2/70) to human la-like antigens. Hum Immunol 3: 211–223
van Heyningen V, Guy K, Newman R, Steel CM (1982) Human MHC class II molecules as differentiation markers. Immunogenetics 16: 459–469
Hurley CK, Shaw S, Nadler L, Schlossman S, Capra JD (1982) Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med 156: 1557–1562
Ozato K, Mayer N, Sachs DH (1980) Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens. J Immunol 124: 533–540
Wernet P, Ziegler A, Shaw S, Blaurock M, Pawelec G (1983) Monoclonal antibodies against la-like antigens inhibiting HLA-D and/or SB-directed secondary proliferative responses. Transplant Proc XV: 94–98
Bodmer J, Heyes J, Lindsay J (1984) Study of monoclonal antibodies to the HLA-D region products DQwl and DRw 52. This volume
Giles RC, Nunez G, Hurley CK, Nunez-Roldan A, Win-chester R, Stastny P, Capra JD (1983) Structural analysis of a human I-A homologue using a monoclonal antibody that recognises an MB3-like specificity. J Exp Med 157: 1461–1470
Goyert SM, Shively JE, Silver J (1982) Biochemical characterization of a second family of human la molecules, HLA-DS, equivalent to murine I-A subregion molecules. J Exp Med 156: 550–566
Makgoba MW, Hildreth JEK, McMichael AJ (1983) Identification of a human la antigen that is different from HLA-DR and DC antigens. Immunogenetics 17: 623–635
Watson AJ, DeMars R, Trowbridge IS, Bach FH (1983) Detection of a novel human class IIHLA antigen. Nature 304: 358–361
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Crumpton, M.J., Bodmer, J.G., Bodmer, W.F., Heyes, J.M., Lindsay, J., Rudd, C.E. (1984). Biochemistry of Class II Antigens: Workshop Report. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_5
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DOI: https://doi.org/10.1007/978-3-642-69770-8_5
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