Antigen Report: HLA-Bw48
This specificity was originally described by our group [1,2] with an antiserum, JA, which also contained Bw40. The specificity is found in 12% of Eskimos, but is very rare in Caucasians. Several sera in this workshop show reactivity with Bw48, but they all have many extra reactions. Based on Japanese data, the serum 9w369, with a Q score of 9.6, can best be used to define Bw48, but also contains anti-Bw60 activity. Thus, Bw48 can only be assigned in the absence of Bw60. Two more sera, 9w368 and 369, may be helpful; both react strongly with nearly all Bw48-positive cells, but include reactions with some B7-positive and B40-positive cells.
- 2.Kissmeyer-Nielsen F, Kjerbye KE, Lamm LU, Jørgensen J, Petersen GB, Gürtler H (1972) Study of the HL-A system in Eskimos. In: Dausset J, Colombani J (eds) Histocompatibility testing 1972. Munksgaard, Copenhagen, pp 317–324Google Scholar