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Antigen Report: HLA-Bw48

  • F. Kissmeyer-Nielsen
  • B. Graugaard
  • L. U. Lamm
  • H. Festenstein
  • A. Alonso
  • E. Williams
Conference paper

Abstract

This specificity was originally described by our group [1,2] with an antiserum, JA, which also contained Bw40. The specificity is found in 12% of Eskimos, but is very rare in Caucasians. Several sera in this workshop show reactivity with Bw48, but they all have many extra reactions. Based on Japanese data, the serum 9w369, with a Q score of 9.6, can best be used to define Bw48, but also contains anti-Bw60 activity. Thus, Bw48 can only be assigned in the absence of Bw60. Two more sera, 9w368 and 369, may be helpful; both react strongly with nearly all Bw48-positive cells, but include reactions with some B7-positive and B40-positive cells.

References

  1. 1.
    Kissmeyer-Nielsen F, Andersen H, Hauge M, Kjerby KE, Mogensen B, Svejgaard A (1971) HL-A types in Danish Eskimos from Greenland. Tissue Antigens 1: 74–80PubMedCrossRefGoogle Scholar
  2. 2.
    Kissmeyer-Nielsen F, Kjerbye KE, Lamm LU, Jørgensen J, Petersen GB, Gürtler H (1972) Study of the HL-A system in Eskimos. In: Dausset J, Colombani J (eds) Histocompatibility testing 1972. Munksgaard, Copenhagen, pp 317–324Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • F. Kissmeyer-Nielsen
    • 1
  • B. Graugaard
    • 1
  • L. U. Lamm
    • 1
  • H. Festenstein
    • 2
  • A. Alonso
    • 2
  • E. Williams
  1. 1.Department of Clinical Immunology, Tissue Typing LaboratoryUniversity Hospital of Arhus CDenmark
  2. 2.Department of ImmunologyThe London Hospital Medical CollegeLondonUK

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