Abstract
As in the previous Workshops, HLA-B27 appears to be one of the best defined antigens. Four sera are very good or excellent (Table 1) as, indicated by their quality scores based on the formula of Mickey and Terasaki. The few extra reactions of the above-mentioned sera are cross-reactions, mostly with B7. Other sera with broader reactivity confirm the existence of the B7-related CREG: B7,B27,Bw22, B40 and Bw47. However, it should be noted that the existence of excellent anti-B27 sera and the absence of data for a B27 split are in sharp contrast with other published data about subtypes of B27. Subtypes of B27 were detected by MoAb B27M2 [1] and by CTLs [2]. Further analysis of the Ninth Workshop MoAbs may possibly help to solve this problem. Indications of the possibility of identifying subtypes of B27 with conventional sera were also found (see De Waal et al., this volume).
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References
Grumet FC, et al (1982) Subtypes of HLA-B27 defined by monoclonal antibody. Hum Immunol 5: 61–72
Breuning MH, et al (1982) Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self recognition. Hum Immunol 5: 259–268
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© 1984 Springer-Verlag Berlin Heidelberg
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Breur, B.S., Ivanyi, P. (1984). Antigen Report: HLA-B27. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_38
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DOI: https://doi.org/10.1007/978-3-642-69770-8_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69772-2
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