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Histocompatibility Testing 1984 pp 138–139Cite as

Antigen Report: HLA-B8

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Abstract

The HLA-B8 antigen has been known since 1965 and its characteristics were summarized in 1980 [4]. Of all the class I antigens studied by Vasilov et al. [8] it has the most acidic isoelectric point. Healthy individuals carrying HLA-B8 (but not all of them) have particular features not found in non-B8 individuals. These concern the decrease of some peripheral blood cell subsets (lymphocytes or monocytes [3, 5]); their IgG secretion when stimulated with PWM [9]; and their response in vitro when cultured with PHA, or Con A [5], with allogeneic or autologous cells [7] or with wheat antigen [2]. However, these features are probably not due to the presence of HLA-B8 itself, but rather to a gene or a set of genes in linkage disequilibrium with HLA-B8 [3,5].

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References

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Author information

Authors and Affiliations

  1. Institut d’Hématologie, Centre de Transfusion Sanguine, 10, rue Spielmann, 67085, Strasbourg Cedex, France

    M. M. Tongio, Y. Mitsuishi, G. Hauptmann & S. Mayer

Authors
  1. M. M. Tongio
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  2. Y. Mitsuishi
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  3. G. Hauptmann
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  4. S. Mayer
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Editor information

Editors and Affiliations

  1. Labor für Immungenetik, Kinderpoliklinik der Universität, Pettenkoferstraße 8a, 8000, München 2, Bundesrepublik Deutschland

    Ekkehard D. Albert

  2. Biometrische Abteilung, Diabetes Forschungsinstitut an der Universität, Auf’m Hennekamp 65, 4000, Düsseldorf 1, Bundesrepublik Deutschland

    Max P. Baur

  3. Institut für Blutgruppenserologie der Universität, Spitalgasse 4, 1090, Wien, Österreich

    Wolfgang R. Mayr

  4. Essen, Germany

    J. Bertrams  & H. Grosse-Wilde  & 

  5. Ulm, Germany

    S. Goldmann

  6. Heidelberg, Germany

    G. Opelz

  7. Bonn, Germany

    C. Rittner

  8. Munich, Germany

    D. J. Schendel , S. Scholz  & R. Wank ,  & 

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© 1984 Springer-Verlag Berlin Heidelberg

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Cite this paper

Tongio, M.M., Mitsuishi, Y., Hauptmann, G., Mayer, S. (1984). Antigen Report: HLA-B8. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_34

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  • DOI: https://doi.org/10.1007/978-3-642-69770-8_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69772-2

  • Online ISBN: 978-3-642-69770-8

  • eBook Packages: Springer Book Archive

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