Advertisement

Long-Term Follow-Up of London Transplant Group (LTG) Renal Transplant Patients

  • H. Festenstein
  • P. Doyle
  • J. Holmes
Conference paper

Abstract

Since 1969, a total of 1284 cadaveric renal transplants have been performed within the LTG. Actuarial graft survival (GS: Peto program) for first grafts is 60% at 1 year, 46% at 5 years, and 36% at 10 years. Retransplants survive significantly less well: 48% at 1 year, 34% at 5 years, and 29% at 10 years (P =0.004). To date 531 transplants have been done since 1978 and their 5-year GS is considerably higher (64% for first transplants, 44% for retransplants). The data show a consistent and highly significant effect of HLA-A and B antigen matching (broad groups) on GS (P < 0.00001) (see Fig. 1). Matching for HLA-B antigens alone produces as significant an effect as matching for both HLA-A and B antigens (P < 0.00001). HLA-A and B matching using cross-reacting groups (CREGs) does not demonstrate a significant influence on GS over and above that produced by HLA-A and B matching for broad groups inherent in the sample.

Keywords

Graft Survival Broad Group Female Recipient Male Kidney Antigen Match 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • H. Festenstein
    • 1
  • P. Doyle
    • 1
  • J. Holmes
    • 1
    • 2
  1. 1.London Hospital Medical CollegeLondonUK
  2. 2.Dept. of Immunology and Hill CentreLondonUK

Personalised recommendations