Long-Term Follow-Up of London Transplant Group (LTG) Renal Transplant Patients
Since 1969, a total of 1284 cadaveric renal transplants have been performed within the LTG. Actuarial graft survival (GS: Peto program) for first grafts is 60% at 1 year, 46% at 5 years, and 36% at 10 years. Retransplants survive significantly less well: 48% at 1 year, 34% at 5 years, and 29% at 10 years (P =0.004). To date 531 transplants have been done since 1978 and their 5-year GS is considerably higher (64% for first transplants, 44% for retransplants). The data show a consistent and highly significant effect of HLA-A and B antigen matching (broad groups) on GS (P < 0.00001) (see Fig. 1). Matching for HLA-B antigens alone produces as significant an effect as matching for both HLA-A and B antigens (P < 0.00001). HLA-A and B matching using cross-reacting groups (CREGs) does not demonstrate a significant influence on GS over and above that produced by HLA-A and B matching for broad groups inherent in the sample.