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Defect of Ferritin Secretion in HLA-A3 Subjects and in Idiopathic Hemochromatosis

  • B. Martins da Silva
  • R. Fauchet
  • B. Genetet
  • L. Le Mignon
  • M. Simon
  • M. de Sousa
Conference paper

Abstract

We previously described an impairment of ferritin secretion in peripheral blood mononuclear cells from normal HLA-A3 subjects following stimulation in vitro with phytohemagglutinin (PHA) and concanavalin A (Con A) with or without addition of ferric citrate [1–3]. We now re-examine the association of ferritin secretion with HLA-A phenotype in a population of controls and idiopathic hemochromatosis (IH) patients in Brittany, the region where family studies first documented a linkage disequilibrium of the HLA-A3 antigen in IH [4].

Keywords

Peripheral Blood Mononuclear Cell Family Study Human Peripheral Blood Peripheral Blood Sample Plaque Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Martins da Silva B, Pollack MS, Dupont B, de Sousa M (1982) A study of ferritin secretion by human peripheral blood mononuclear cells from HLA typed donors. In: Saltman P, Hegenauer J (eds) The biochemistry and physiology of iron. Elsevier/North Holland, Amsterdam, pp 733–737Google Scholar
  2. 2.
    De Sousa M, Martins da Silva B, Dörner MH, Munn G, Nishiya K, Grady R, Silverstone AE (1982) Iron as a target of immune surveillance. In: Saltman P, Hegenauer J (eds) The biochemistry and physiology of iron. Elsevier/ North Holland, AmsterdamGoogle Scholar
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    Pollack MS, Martins da Silva B, Moshief DR, Groshen S, Bognacki J, Dupont B, de Sousa M (1983) Ferritin secretion by human mononuclear cells: Association with HLA phenotype. Clin Immunol Immunopathol 27: 124–134PubMedCrossRefGoogle Scholar
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    Simon M, Bourel M, Fauchet R, Genetet B (1976) Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut 17: 332–334PubMedCrossRefGoogle Scholar
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    Simon M, Haspel P, Brissot P, Fauchet R, Edan G, Le Reun M, Le Mignon L, Genetet B, Bourel M (1981) Les hémochromatoses. Ann Med Interne (Paris) 132: 413–433Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • B. Martins da Silva
    • 1
  • R. Fauchet
    • 2
  • B. Genetet
    • 2
  • L. Le Mignon
    • 2
  • M. Simon
    • 2
  • M. de Sousa
    • 1
  1. 1.Abel Salazar Institute for the Biomedical SciencesLargo da Escola MédicaOportoPortugal
  2. 2.Laboratoire Régional de Transfusion SanguineRennesFrance

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