Defect of Ferritin Secretion in HLA-A3 Subjects and in Idiopathic Hemochromatosis

  • B. Martins da Silva
  • R. Fauchet
  • B. Genetet
  • L. Le Mignon
  • M. Simon
  • M. de Sousa
Conference paper

Abstract

We previously described an impairment of ferritin secretion in peripheral blood mononuclear cells from normal HLA-A3 subjects following stimulation in vitro with phytohemagglutinin (PHA) and concanavalin A (Con A) with or without addition of ferric citrate [1–3]. We now re-examine the association of ferritin secretion with HLA-A phenotype in a population of controls and idiopathic hemochromatosis (IH) patients in Brittany, the region where family studies first documented a linkage disequilibrium of the HLA-A3 antigen in IH [4].

Keywords

Citrate Ferritin Concanavalin Hemochromatosis 

References

  1. 1.
    Martins da Silva B, Pollack MS, Dupont B, de Sousa M (1982) A study of ferritin secretion by human peripheral blood mononuclear cells from HLA typed donors. In: Saltman P, Hegenauer J (eds) The biochemistry and physiology of iron. Elsevier/North Holland, Amsterdam, pp 733–737Google Scholar
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    Pollack MS, Martins da Silva B, Moshief DR, Groshen S, Bognacki J, Dupont B, de Sousa M (1983) Ferritin secretion by human mononuclear cells: Association with HLA phenotype. Clin Immunol Immunopathol 27: 124–134PubMedCrossRefGoogle Scholar
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    Simon M, Haspel P, Brissot P, Fauchet R, Edan G, Le Reun M, Le Mignon L, Genetet B, Bourel M (1981) Les hémochromatoses. Ann Med Interne (Paris) 132: 413–433Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • B. Martins da Silva
    • 1
  • R. Fauchet
    • 2
  • B. Genetet
    • 2
  • L. Le Mignon
    • 2
  • M. Simon
    • 2
  • M. de Sousa
    • 1
  1. 1.Abel Salazar Institute for the Biomedical SciencesLargo da Escola MédicaOportoPortugal
  2. 2.Laboratoire Régional de Transfusion SanguineRennesFrance

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