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Presence of Thyroid-Stimulating Immunoglobulins (TSI) in DR3 Positive Normal Individuals

  • J. Charreire
  • G. Karsenty
  • V. Lepage
  • L. Degos
Conference paper

Abstract

With the method of thyroid epithelial cell culture (TEC) that we developed in mice [1], monolayers of human TEC (HTEC) were used to detect thyroid- stimulating immunoglobulins (TSI) in a functional assay of cyclic AMP (cAMP) production. Under these experimental conditions, we previously demonstrated the presence of TSI in 92% of untreated Graves disease (GD) patients and their disappearance 6 months after neomercazole treatment in 55% of the GD patients [2]. In this study, TSI positivity was evaluated as the percentage of response when DEAE-trisacryl-purified IgGs from normal subjects were deposited onto HTEC for cAMP production. Among the 32 samples provided by the blood bank and used as controls, we found four TSI-positive subjects with euthyroid status.

Keywords

Normal Individual cAMP Level Grave Disease Functional Assay Blood Bank 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Salamero J, Michel-Béchet M, Charreire J (1983) Expression of H-2 antigens and thyroglobulin (Tg) on freshly dissociation and in vitro cultured monolayers of mouse thyroid epithelial cells ( TEC ). Tissue Antigens 22: 231–238PubMedCrossRefGoogle Scholar
  2. 2.
    Charreire J, Karsenty G, Bouchard P, Schaison B (1984) Effect of Neomercazole (NMZ) treatment in patients with Graves diseases ( GD ). Clin Exp Immunol 57: 633PubMedGoogle Scholar
  3. 3.
    Briones-Urbina R, Bear JC, Farid NR (1982) Association of hypergammaglobulinemia G with HLA-DR3 in Graves’ disease. Tissue Antigens 19: 20–24PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • J. Charreire
    • 1
  • G. Karsenty
    • 1
  • V. Lepage
    • 2
  • L. Degos
    • 2
  1. 1.INSERM U25Hôpital Necker Enfants MaladesParisFrance
  2. 2.INSERM U90Hôpital Saint-LouisParisFrance

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