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Absence of DQw1 on Monocytes Depending on the DR Antigens Expressed

  • L. Gebuhrer
  • H. Bétuel
  • J. Lambert
  • A. C. Freidel
Conference paper

Abstract

DQw1 was originally defined serologically as a supertypic specificity comprising DR1, 2, w6, w10. DRw52 correlates with DR3, 5, w6, w8. Structural studies indicate that DQw1 represents a locus distinct from DR, controlling DQ products [2]; it seems that DRw52 products are governed by DR and by DQ [3]. HLA DRw6 is heterogeneous; at the Eighth Histocompatibility Workshop (H.W.) three subsets were proposed but not unanimously agreed on. At the Ninth H.W., serological distinction is still arduous, while two distinct DW subsets appear to exist. Monocytes and B cells from the same individuals were separated and tested by complement- dependent cytotoxicity tests with anti-class II reagents of the Ninth H. W. We examined 25 unrelated cells from our panel and four D-homozygous typing cells (HTCs): two defined the Dw6.1 subset, one recognized Dw6.2, and one typed for Dw9. We have provisionally kept the Eighth H.W. nomenclature for the HTCs defining DRw6.

Keywords

Public Health Blood Transfusion Structural Study Concomitant Presence Number Monocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gonwa TA, Picker LJ, Raff HV, Goyert SM, Silver J, StoboJD (1983) J Immunol 130: 706–711PubMedGoogle Scholar
  2. 2.
    Goyert SM, Shively JE, Silver J (1982) J Exp Med 156: 550–560PubMedCrossRefGoogle Scholar
  3. 3.
    Karr RW, Kannapell CC, Stein JA, Gebel HM, Mann DL, Duquesnoy RJ, Fuller TC, Rodey GE, Schwartz BD (1981) J Immunol 128: 1809–1818Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • L. Gebuhrer
    • 1
  • H. Bétuel
    • 1
  • J. Lambert
    • 1
  • A. C. Freidel
    • 1
  1. 1.Histocompatibility LaboratoryBlood Transfusion CenterLyonFrance

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