Absence of DQw1 on Monocytes Depending on the DR Antigens Expressed
DQw1 was originally defined serologically as a supertypic specificity comprising DR1, 2, w6, w10. DRw52 correlates with DR3, 5, w6, w8. Structural studies indicate that DQw1 represents a locus distinct from DR, controlling DQ products ; it seems that DRw52 products are governed by DR and by DQ . HLA DRw6 is heterogeneous; at the Eighth Histocompatibility Workshop (H.W.) three subsets were proposed but not unanimously agreed on. At the Ninth H.W., serological distinction is still arduous, while two distinct DW subsets appear to exist. Monocytes and B cells from the same individuals were separated and tested by complement- dependent cytotoxicity tests with anti-class II reagents of the Ninth H. W. We examined 25 unrelated cells from our panel and four D-homozygous typing cells (HTCs): two defined the Dw6.1 subset, one recognized Dw6.2, and one typed for Dw9. We have provisionally kept the Eighth H.W. nomenclature for the HTCs defining DRw6.
- 3.Karr RW, Kannapell CC, Stein JA, Gebel HM, Mann DL, Duquesnoy RJ, Fuller TC, Rodey GE, Schwartz BD (1981) J Immunol 128: 1809–1818Google Scholar