Antigen-Specific T Cell Clones Restricted by DR, DQ, or DP Class II HLA Molecules

  • E. Qvigstad
  • G. Gaudernack
  • T. Moen
  • E. Thorsby
Conference paper

Abstract

Human T4 cells corecognize antigenic epitopes together with restriction elements on class II HLA molecules in membranes of antigen-presenting cells (APCs). In man, at least three different class II HLA molecules have been detected: DR, DQ, and DP. Antigen-specific (i.e., Chlamydia trachomatis-specific) proliferative T4 clones (TLCs) may be restricted by elements on DR, DQ, or DP molecules [9, 12]. The inhibitory effect of a panel of murine monoclonal antibodies (Mabs) directed against HLA molecules of the APCs was studied to further dissect the restriction specificities of the TLCs.

Keywords

Influenza Tetanus Ferrone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • E. Qvigstad
    • 1
  • G. Gaudernack
    • 1
  • T. Moen
    • 1
  • E. Thorsby
    • 1
  1. 1.Institute of Transplantation ImmunologyThe National Hospital (Rikshospitalet)Oslo 1Norway

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