Antigen-Specific T Cell Clones Restricted by DR, DQ, or DP Class II HLA Molecules
Human T4 cells corecognize antigenic epitopes together with restriction elements on class II HLA molecules in membranes of antigen-presenting cells (APCs). In man, at least three different class II HLA molecules have been detected: DR, DQ, and DP. Antigen-specific (i.e., Chlamydia trachomatis-specific) proliferative T4 clones (TLCs) may be restricted by elements on DR, DQ, or DP molecules [9, 12]. The inhibitory effect of a panel of murine monoclonal antibodies (Mabs) directed against HLA molecules of the APCs was studied to further dissect the restriction specificities of the TLCs.
KeywordsChlamydia Trachomatis Murine Monoclonal Antibody Restriction Element Chlamydial Antigen Dilution X102
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