Antigen-Specific T Cell Clones Restricted by DR, DQ, or DP Class II HLA Molecules

  • E. Qvigstad
  • G. Gaudernack
  • T. Moen
  • E. Thorsby
Conference paper


Human T4 cells corecognize antigenic epitopes together with restriction elements on class II HLA molecules in membranes of antigen-presenting cells (APCs). In man, at least three different class II HLA molecules have been detected: DR, DQ, and DP. Antigen-specific (i.e., Chlamydia trachomatis-specific) proliferative T4 clones (TLCs) may be restricted by elements on DR, DQ, or DP molecules [9, 12]. The inhibitory effect of a panel of murine monoclonal antibodies (Mabs) directed against HLA molecules of the APCs was studied to further dissect the restriction specificities of the TLCs.


Chlamydia Trachomatis Murine Monoclonal Antibody Restriction Element Chlamydial Antigen Dilution X102 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • E. Qvigstad
    • 1
  • G. Gaudernack
    • 1
  • T. Moen
    • 1
  • E. Thorsby
    • 1
  1. 1.Institute of Transplantation ImmunologyThe National Hospital (Rikshospitalet)Oslo 1Norway

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