Relationship Between the OKT Phenotype of Alloreactive Human T Cell Clones and Their Specificity for HLA Class II Antigens

  • X. Chardonnens
  • G. Morgan
  • M. Jeannet
Conference paper

Abstract

It has recently been suggested that the phenotype of T cells is not associated with their function but with the class of MHC antigens they recognize, and that OKT4 and OKT8 molecules function as receptors for distinct classes of HLA alloantigens. The recent development of techniques allowing the cloning and proliferation of functional T cells, coupled with the use of monoclonal antibodies, allows us to examine whether a relationship exists between surface markers of the clones, their functional activity, and their specificity for class I or II HLA antigens.

References

  1. 1.
    Chardonnens X, Froment Y, Morgan G, Jeannet M (1983) Human T cell clones allospecific for HLA-DR5 antigen with the OKT8 phenotype. Tissue Antigens 22: 76–81PubMedCrossRefGoogle Scholar
  2. 2.
    Wee SL, Chen LK, Strassmann G, Bach FH (1982) Helper-cell-independent cytotoxic clones in man. J Exp Med 156: 1854–1859PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • X. Chardonnens
    • 1
  • G. Morgan
    • 1
  • M. Jeannet
    • 1
  1. 1.Transplantation Immunology Unit, Division of Immunology and AllergologyHôpital Cantonal UniversitaireGenevaSwitzerland

Personalised recommendations