Genetic Control of HLA-Linked Immune Responsiveness to Synthethic Polypeptides in Healthy Individuals and Patients with Autoimmune Diseases
The association between the HLA system and susceptibility to various diseases and in particular diseases with immunological disorders is well known . However, the identification of the mechanisms by which various HLA factors cause susceptibility to a variety of diseases is yet to be clarified. The existence of immune response genes and their linkage to the major histocompatibility complex has been established in many species [2, 9, 12]. For a better understanding of HLA and disease associations it is of importance to elucidate the function of immune response (Ir) genes in man. However, in the human, studies on Ir genes have been limited due to genetic heterogeneity of the random population, complexity of the antigens relevant to diseases, constraints of immunization with foreign antigens, and lack of adequate in vitro systems for these studies.
KeywordsPolypeptide Haplo LGlu LTyr
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