Abstract
The existence of at least three sets of cell surface products encoded by the HLA-D region — DR, DQ and DP — has been established by serological, cellular biochemical and molecular studies [for reviews see 1, 2]. The initial definition of DR was based on alloantisera reactive against B cell determinants, which showed extensive polymorphism. Serological and biochemical studies of the cross-reactive determinants detected within the DR series indicated the existence of a second allelic series of cell surface products, DQ (DC or MB), which are in strong linkage disequilibrium with DR alleles. Subsequently, a third series, DP (SB), was defined by primed lymphocyte typing [3], and available biochemical studies show that it is distinct from DR and DQ [4]. A fourth set of products, closely related to DR, has been described [5]. They are probably the antigens recognised by the MT or BR group of apparently cross-reactive sera [6], and are also coded for in the DR subregion.
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References
Bodmer WF, Bodmer JG, Lee J, So A, Spielman R, Travers P, Trowsdale J (1984) Molecular genetics of the HLA-D region. Gorer Symposium. J Immunogenet (in press)
Kaufman JF, Auffray C, Kouman AJ, Shackelford DA, Strominger JL (1984) The class II molecules of the human and murine major histocompatibility complex. Cell 36:1–13
Shaw J, Kavathas P, Pollack MA, Charmot D, Mawas C (1981) Family studies define a new histocompatibility locus SB, between HLA-DR and GLO. Nature 293:745–747
Shackelford DA, Kaufman JF, Kouman AJ, Strominger JL (1982) HLA-DR antigens: structure, separation of subpopulations. Gene cloning and function. Immunol Rev 66:133–187
Tanigaki N, Tosi R, Duquesnoy RJ, Ferrara GB (1983) Three la species with different structures and alloantigenic determinants in an HLA-homozygous cell line. J Exp Med 157:231–247
Shackelford DA, Strominger JL (1984) Identification of three class II antigens, DR7, MB2, and MT3 from a homozygous human cell line. Hum Immunol 9:159–174
Wake CT, Long EO, Mach B (1982) Allelic polymorphism and complexity of the genes for HLA-DRß chains. Nature 300:372–374
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517
Spielman R, Lee J, Bodmer WF, Bodmer J, Trowsdale J (1984) Six HLA-D region α chain genes on human chromosome 6. Proc Natl Acad Sci USA 81:3461–3465
Trowsdale J, Lee J, Carey J, Grosveld F, Bodmer J, Bodmer WF (1983) Sequences related to HLA-DRα chains on human chromosome 6. Proc Natl Acad Sci USA 80:1972–1976
de Kretser TA, Crumpton MJ, Bodmer JG, Bodmer WF (1982) Two-dimensional gel analysis of the polypeptides precipitated by a polymorphic HLA-DR 1, 2 and w6 monoclonal antibody. Eur J Immunol 12:600–606
Long EO, Wake CT, Strubin M, Gross N, Aciolla R, Carrel S, Mach B (1982) Isolation of distinct cDNA clones encoding HLA-DRß chains by use of an expression assay. Proc Natl Acad Sci USA 79:7465–7469
Trowsdale J, Kelly A, Lee J, Carson S, Austin P, Travers P (1984) A linkage map of two SBα and ß related genes. Cell 38:241–249
Owerbach D, Lernmark A, Rask L, Peterson PA, Platz P, Svejgaard A (1983) Detection of HLA-D/DR-related DNA polymorphism in HLA-D homozygous typing cells. Proc Natl Acad Sci USA 80:3758–3761
Bodmer WF, Bodmer J, Lee J, Spielman R, Travers P, Trowsdale J (1984) Structure, evolution and polymorphism of the HLA-D region. Immunogenetics - its application to clinical medicine. Academic, London (in press)
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© 1984 Springer-Verlag Berlin Heidelberg
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So, A.K.L., Trowsdale, J., Bodmer, J.G., Bodmer, W.F. (1984). DNA Polymorphism of HLA-DRβ and HLA-DPβ Genes. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_205
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DOI: https://doi.org/10.1007/978-3-642-69770-8_205
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