DNA Polymorphism of HLA-DRβ and HLA-DPβ Genes
The existence of at least three sets of cell surface products encoded by the HLA-D region — DR, DQ and DP — has been established by serological, cellular biochemical and molecular studies [for reviews see 1, 2]. The initial definition of DR was based on alloantisera reactive against B cell determinants, which showed extensive polymorphism. Serological and biochemical studies of the cross-reactive determinants detected within the DR series indicated the existence of a second allelic series of cell surface products, DQ (DC or MB), which are in strong linkage disequilibrium with DR alleles. Subsequently, a third series, DP (SB), was defined by primed lymphocyte typing , and available biochemical studies show that it is distinct from DR and DQ . A fourth set of products, closely related to DR, has been described . They are probably the antigens recognised by the MT or BR group of apparently cross-reactive sera , and are also coded for in the DR subregion.
KeywordsSerological Type Serological Specificity Imperial Cancer Research Fund Murine Major Histocompatibility Complex Homozygous Typing Cell
Unable to display preview. Download preview PDF.
- 1.Bodmer WF, Bodmer JG, Lee J, So A, Spielman R, Travers P, Trowsdale J (1984) Molecular genetics of the HLA-D region. Gorer Symposium. J Immunogenet (in press)Google Scholar
- 15.Bodmer WF, Bodmer J, Lee J, Spielman R, Travers P, Trowsdale J (1984) Structure, evolution and polymorphism of the HLA-D region. Immunogenetics - its application to clinical medicine. Academic, London (in press)Google Scholar