HLA-FA: A Non-DR, Non-DQ HLA Class II Product
We have used a monoclonal antibody (mcAb) supplied by Dr. Ian Trowbridge to define a non-DR, non-DQ HLA class II molecule which we have provisionally termed HLA-FA; certain features of this molecule are unusual as compared with HLA-DR and HLA-DQ , First, there is a molecular weight polymorphism of the FA β chain, ranging from 25K to 27K; second, the FA α chain is virtually inaccessible to lactoperoxidase-catalyzed iodination (125I), though it can be readily visualized with metabolic labeling.
KeywordsMetabolic Label National Multiple Sclerosis Society Dime Birth Defect Foundation Heterozygous Cell Line Hybrid Determinant
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