HLA-FA: A Non-DR, Non-DQ HLA Class II Product
We have used a monoclonal antibody (mcAb) supplied by Dr. Ian Trowbridge to define a non-DR, non-DQ HLA class II molecule which we have provisionally termed HLA-FA; certain features of this molecule are unusual as compared with HLA-DR and HLA-DQ , First, there is a molecular weight polymorphism of the FA β chain, ranging from 25K to 27K; second, the FA α chain is virtually inaccessible to lactoperoxidase-catalyzed iodination (125I), though it can be readily visualized with metabolic labeling.
KeywordsMigration Iodi Polypeptide
- 3.Bach FH, Groner J, Watson AJ, Reinsmoen N, Segall M (1984) HLA class II molecules: T cell response and molecular characterization. In: Sasazuki T, Tada T (eds) Immunogenetics: its application to clinical medicine. Academic, Tokyo (in press)Google Scholar
- 4.Reinsmoen NL, Bach FH (1983) HLA-D region complexity associated with HLA-DR, Dw, and SB phenotypes. Trans Proc XV, 1: 76–78Google Scholar
- 5.Watson AJ, Bach FH (1984) Structural polymorphism of FA: an HLA class II antigen with unusual molecular properties (submitted)Google Scholar