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HLA-FA: A Non-DR, Non-DQ HLA Class II Product

  • K. M. Linner
  • F. H. Bach

Abstract

We have used a monoclonal antibody (mcAb) supplied by Dr. Ian Trowbridge to define a non-DR, non-DQ HLA class II molecule which we have provisionally termed HLA-FA; certain features of this molecule are unusual as compared with HLA-DR and HLA-DQ [1], First, there is a molecular weight polymorphism of the FA β chain, ranging from 25K to 27K; second, the FA α chain is virtually inaccessible to lactoperoxidase-catalyzed iodination (125I), though it can be readily visualized with metabolic labeling.

Keywords

Metabolic Label National Multiple Sclerosis Society Dime Birth Defect Foundation Heterozygous Cell Line Hybrid Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Watson A, DeMars R, Trowbridge IS, Bach FH (1983) Detection of a novel human class II HLA antigen. Nature 304: 358–361PubMedCrossRefGoogle Scholar
  2. 2.
    Shaw S, Pollack MS, Payne SM, Johnson AH (1980) HLA-linked B cell alloantigens of a new segregant series: population and family studies of the SB antigens. Hum Immunol 1: 177–185PubMedCrossRefGoogle Scholar
  3. 3.
    Bach FH, Groner J, Watson AJ, Reinsmoen N, Segall M (1984) HLA class II molecules: T cell response and molecular characterization. In: Sasazuki T, Tada T (eds) Immunogenetics: its application to clinical medicine. Academic, Tokyo (in press)Google Scholar
  4. 4.
    Reinsmoen NL, Bach FH (1983) HLA-D region complexity associated with HLA-DR, Dw, and SB phenotypes. Trans Proc XV, 1: 76–78Google Scholar
  5. 5.
    Watson AJ, Bach FH (1984) Structural polymorphism of FA: an HLA class II antigen with unusual molecular properties (submitted)Google Scholar
  6. 6.
    Kaufman JF, Strominger JL (1982) HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region. Nature 297: 694–697PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • K. M. Linner
    • 1
  • F. H. Bach
    • 1
  1. 1.Dept. of Lab. Medicine and PathologyMinneapolisUSA

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