HLA-FA: A Non-DR, Non-DQ HLA Class II Product

  • K. M. Linner
  • F. H. Bach

Abstract

We have used a monoclonal antibody (mcAb) supplied by Dr. Ian Trowbridge to define a non-DR, non-DQ HLA class II molecule which we have provisionally termed HLA-FA; certain features of this molecule are unusual as compared with HLA-DR and HLA-DQ [1], First, there is a molecular weight polymorphism of the FA β chain, ranging from 25K to 27K; second, the FA α chain is virtually inaccessible to lactoperoxidase-catalyzed iodination (125I), though it can be readily visualized with metabolic labeling.

Keywords

Migration Iodi Polypeptide 

References

  1. 1.
    Watson A, DeMars R, Trowbridge IS, Bach FH (1983) Detection of a novel human class II HLA antigen. Nature 304: 358–361PubMedCrossRefGoogle Scholar
  2. 2.
    Shaw S, Pollack MS, Payne SM, Johnson AH (1980) HLA-linked B cell alloantigens of a new segregant series: population and family studies of the SB antigens. Hum Immunol 1: 177–185PubMedCrossRefGoogle Scholar
  3. 3.
    Bach FH, Groner J, Watson AJ, Reinsmoen N, Segall M (1984) HLA class II molecules: T cell response and molecular characterization. In: Sasazuki T, Tada T (eds) Immunogenetics: its application to clinical medicine. Academic, Tokyo (in press)Google Scholar
  4. 4.
    Reinsmoen NL, Bach FH (1983) HLA-D region complexity associated with HLA-DR, Dw, and SB phenotypes. Trans Proc XV, 1: 76–78Google Scholar
  5. 5.
    Watson AJ, Bach FH (1984) Structural polymorphism of FA: an HLA class II antigen with unusual molecular properties (submitted)Google Scholar
  6. 6.
    Kaufman JF, Strominger JL (1982) HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region. Nature 297: 694–697PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • K. M. Linner
    • 1
  • F. H. Bach
    • 1
  1. 1.Dept. of Lab. Medicine and PathologyMinneapolisUSA

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