Serological and Structural Heterogeneity of HLA-DR4 Alloantigens

  • M. Igarashi
  • M. Yoshii
  • N. Kashiwagi
  • T. Crepaldi
  • S. Ferrone
Conference paper

Abstract

Testing of a large panel of anti-class II monoclonal antibodies (MoAb) with the lymphoid cell lines FS, L-KT9, L-KT13, THO, and WALK carrying serologically indistinguishable DR4 allospecificities but different cellularly defined HLA-D allospecificities showed that the anti-HLA-DR MoAb Q2/80 displayed differential reactivity with the cell lines (Table 1).

Keywords

HPLC Leukemia Electrophoresis Allo Tunicamycin 

References

  1. 1.
    Groner JP, Watson AJ, Bach FH (1983) Dw/LD-related molecular polymorphism of DR4 β-chains. J Exp Med 157: 1687–1691PubMedCrossRefGoogle Scholar
  2. 2.
    Nepom BS, Nepom GT, Mickelson E, Antonelli P, Hansen JA (1983) Electrophoretic analysis of human HLA- DR antigens from HLA-DR4 homozygous cell lines: Correlation between β-chain diversity and HLA-D. Proc Natl Acad Sci USA 80: 6962–6966PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • M. Igarashi
    • 1
  • M. Yoshii
    • 2
  • N. Kashiwagi
    • 2
  • T. Crepaldi
    • 1
  • S. Ferrone
    • 1
  1. 1.Dept. of Microbiology and ImmunologyNew York Medical CollegeValhallaUSA
  2. 2.Dept. of Transplantation ImmunologyKitasato University, School of MedicineSagamihara, KanagawaJapan

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