Human T Cell Clone Inhibition by Distinct Monoclonal Anti-HLA-DR Antibodies

  • F. Triebel
  • D. J. Charron
  • P. Debré
Conference paper

Abstract

Inhibition studies of the specific proliferative response of T cell clones with different anti-HLA-DR monoclonal antibodies (moAb) should help to relate the structure and the function of multiple DR epitopes. We now describe the inhibition of diphtheria toxoid- and Varidase-specific T cell clone proliferative responses in a single DRw6/7 donor by eight distinct monoclonal anti-HLA-DR moAbs. These moAbs were selected because they have already been biochemically characterized. MoAbs 141, D1.12, VI-15 C, and 157, which detected very similar epitopic specificities, immunoprecipitated only DR molecules on DR 1 - w8. MoAbs 206 and 135, which detected different epitopes, recognized DR (I-E-like) molecules in most of the alleles and also DQ (I-A-like) molecules in DR7 individuals. BM 50 recognized molecules of all alleles except DR7 and the corresponding subgroup of DRw6. MoAbs 141 and 135, 157, and BM 50 shared idiotypic specificities.

Keywords

Lymphoma Influenza Diphtheria 

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • F. Triebel
    • 1
  • D. J. Charron
    • 1
  • P. Debré
    • 1
  1. 1.Laboratoire d’ImmunogénétiqueCHU Pitié-SalpétrièreParisFrance

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