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Serological Analysis of Two Monoclonal Antibodies: One Detecting an DRw53 Supertypic Determinant and One Detecting a New Supertypic Determinant Related to HLA-DR7

  • K. Horibe
  • R. W. Knowles
  • M. S. Pollack
  • B. Dupont
Conference paper

Abstract

Two cytotoxic monoclonal antibodies (MoAbs), PL3 (IgG3) and PL2 (IgG2a), were produced by immunization with an HLA-DR7 homozygous cell line, PLH. Their serological specificities were determined by binding assays and by complement-dependent microcytotoxicity on an extensive cell panel.

Keywords

Mixed Lymphocyte Culture Nylon Wool Serological Specificity Imperial Cancer Research Fund Page Sodium Dodecyl Sulphate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • K. Horibe
    • 1
  • R. W. Knowles
    • 1
  • M. S. Pollack
    • 1
  • B. Dupont
    • 1
  1. 1.Sloan-Kettering Memorial Cancer CenterNew YorkUSA

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