Advertisement

Leprosy

  • R. R. P. de Vries
  • S. W. Serjeantson
  • Z. Layrisse

Abstract

Leprosy is a chronic infectious disease which presently affects more than 15 million individuals. The disease is the result of the interaction between Mycobacterium leprae and the immune system of the infected host, M. leprae by itself being a virtually harmless bacillus. Apparently the majority of individuals exposed to or infected with M. leprae develops effective immunity to M. leprae without disease. A minority, however, may develop a wide range of clinical symptoms, which show striking interindividual variability. This clinical spectrum closely parallels the immunological spectrum of responsiveness displayed by the host [1,2].

Keywords

Coeliac Disease Recombination Fraction Clinical Type Leprosy Patient Healthy Sibling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Godal T (1978) Immunological aspects of leprosy: present status. Prog Allergy 25: 211–242PubMedGoogle Scholar
  2. 2.
    Ridley DS, Jopling WH (1966) Classification of leprosy according to immunity. A five group system. Int J Lepr 34: 225–273Google Scholar
  3. 3.
    De Vries RRP, van Eden W, Van Rood JJ (1981) HLA- linked control of the course of M. leprae infections. Lepr Rev 52 suppl 1: 109–119Google Scholar
  4. 4.
    Serjeantson SW (1983) HLA and susceptibility to leprosy. Immunol Rev 70: 24 - 47CrossRefGoogle Scholar
  5. 5.
    Van Eden W, de Vries RRP (1984) HLA and leprosy: a re-evaluation. Lepr Rev 55: 89–104Google Scholar
  6. 6.
    De Vries RRP, van Eden W, Ottenhoff THM (1984) HLA class II immune response genes and products in leprosy. Prog Allergy (in press)Google Scholar
  7. 7.
    De Vries RRP, Lai A Fat RFM, Nijenhuis LE, Van Rood JJ (1976) HLA-linked genetic control of host response to Mycobacterium leprae. Lancet 2: 1328–1330PubMedCrossRefGoogle Scholar
  8. 8.
    Ott J (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet 26: 588–597PubMedGoogle Scholar
  9. 9.
    Skamene E, Gros P, Forget A, Kongshavn PAL, St Charles C, Taylor BA (1982) Genetic regulation of resistance to intracellular pathogens. Nature 297: 506–509PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • R. R. P. de Vries
    • 1
  • S. W. Serjeantson
    • 2
  • Z. Layrisse
    • 3
  1. 1.Dept. of Immunohematology and Blood BankUniversity HospitalLeidenThe Netherlands
  2. 2.Dept. of Human BiologyJohan Curtin School of Medical ResearchCanberraAustralia
  3. 3.Instituto Venezuelano de Investigaciones Cientificas (IVIC)CaracasVenezuela

Personalised recommendations