Abstract
Different autoimmune diseases often occur together in the same individual or family. Among the clustering autoimmune diseases, those mainly observed are insulin-dependent (type 1) diabetes mellitus (IDDM), diseases of the thyrogastric group [autoimmune thyroid disease (ATD); Graves’ disease, Hashimoto’s disease], and rheumatoid arthritis (RA). This clinical observation suggests a shared etiology due to genetic predisposition which is supported by the fact that these clustering autoimmune diseases are associated with the same HLA antigens: DR3 and DR4. For example, IDDM and ATD are significantly associated with DR3, while DR4-associated diseases include IEpM and RA.
The study was supported by the Deutsche Forschungsgemeinschaft, SFB 113, project B3 and B8
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References
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© 1984 Springer-Verlag Berlin Heidelberg
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Bertrams, J., Baur, M.P. (1984). Insulin-Dependent Diabetes Mellitus. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_118
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DOI: https://doi.org/10.1007/978-3-642-69770-8_118
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