Properdin Factor B

  • S. W. Serjeantson


The properdin factor B (BF) polymorphism comprises two common alleles, F and S; two less common alleles, Fl and SO.7 (previously termed SI); and several further rare alleles, described by Mauff et al. [1]. These electrophoretic variants have been used in traditional linkage analyses to map the structural gene coding for factor B between HLA-B and HLA-DR [2]. Molecular mapping [3] suggests a single factor B locus in this region, closely linked with the C2 locus and proximal to C4A and C4B loci.


Major Histocompatibility Complex Human Major Histocompatibility Complex Electrophoretic Variant Oriental Population Human Major Histocompatibility Complex Class 
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  1. 1.
    Mauff G, Hauptmann G, Hitzeroth HW, Gauchel F, Scherz F (1978) The nomenclature of properdin factor B allotypes. Z Immunforsch 154: 115Google Scholar
  2. 2.
    Weitkamp LR, Lamm LU (1982) Report of the committee on the genetic constitution of chromosome 6. Cytogenet Cell Genet 32: 130PubMedCrossRefGoogle Scholar
  3. 3.
    Carroll MC, Campbell RD, Bentley DR, Porter RR (1984) A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237–241Google Scholar
  4. 4.
    4.Suciu-Foca N, O’Neill G, Rubenstein P (1980) Evidence for the existence of a possible Bf “null” allele. In: Terasaki PI (ed) Histocompatibility testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, p 935Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • S. W. Serjeantson
    • 1
  1. 1.John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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