Properdin Factor B

  • S. W. Serjeantson


The properdin factor B (BF) polymorphism comprises two common alleles, F and S; two less common alleles, Fl and SO.7 (previously termed SI); and several further rare alleles, described by Mauff et al. [1]. These electrophoretic variants have been used in traditional linkage analyses to map the structural gene coding for factor B between HLA-B and HLA-DR [2]. Molecular mapping [3] suggests a single factor B locus in this region, closely linked with the C2 locus and proximal to C4A and C4B loci.




  1. 1.
    Mauff G, Hauptmann G, Hitzeroth HW, Gauchel F, Scherz F (1978) The nomenclature of properdin factor B allotypes. Z Immunforsch 154: 115Google Scholar
  2. 2.
    Weitkamp LR, Lamm LU (1982) Report of the committee on the genetic constitution of chromosome 6. Cytogenet Cell Genet 32: 130PubMedCrossRefGoogle Scholar
  3. 3.
    Carroll MC, Campbell RD, Bentley DR, Porter RR (1984) A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237–241Google Scholar
  4. 4.
    4.Suciu-Foca N, O’Neill G, Rubenstein P (1980) Evidence for the existence of a possible Bf “null” allele. In: Terasaki PI (ed) Histocompatibility testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, p 935Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • S. W. Serjeantson
    • 1
  1. 1.John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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