Diagnosis, Pathogenesis, and Treatment of the Sleep Apnea Syndromes

  • Ch. Guilleminault
Conference paper
Part of the Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics book series (KINDERHEILK. NF, volume 52)


For many years respiration during sleep was thought to follow patterns similar to those observed during wakefulness, but the dicovery of two different states of sleep — rapid eye movement (REM) and non-rapid eye movement (NREM) — led to a reappraisal of respiration and ventilation during sleep in humans and other mammals [6]. It is difficult to study the central control of breathing, and for a number of years investigators have used convenient anesthetic preparations. Recent studies have clearly demonstrated, however, that multiple efferent pathways are eliminated in such preparations, so that results of these experiments are valid only for anesthetized animals, not for understanding ventilation during wakefulness, NREM sleep, and REM sleep. Future studies on respiration and ventilation during sleep will have to use the chronically implanted preparations used in studying the basic phenomena of sleep physiology.

Key words

Sleep apnea cephalometrics imaging palatopharyngoplasty maxillo-facial surgery gastric stapling drug treatment of sleep apnea polygraphic recording central apnea obstructive apnea 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Ch. Guilleminault
    • 1
  1. 1.Sleep Disorders Center, TD-114Stanford University School of MedicineStanfordUSA

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