Molecular Targets of Anti-Glutamine Therapy with Acivicin in Cancer Cells
Systematic studies in this laboratory showed that there was an increase in the activities of enzymes of glutamine utilization of pyrimidine and purine biosynthesis in rat hepatomas of different growth rates and in other animal and human neoplasms. We also observed that there were increased concentrations of strategic nucleotides and deoxynucleotides in hepatomas and these elevations were linked with neoplastic transformation and progression (for overview see Weber ). Because of this increase in enzymic activities and nucleotide pools relating to glutamine utilization, an investigation was carried out to understand the impact of the anti-glutamine agent, acivicin, on the molecular targets, namely, key enzymic activities and concentrations of strategic nucleotides. These studies revealed a profound influence of the anti-glutamine agent on the enzymology and metabolism and survival of cancer cells [1, 3, 15].
KeywordsGlutamine Concentration Purine Biosynthesis Pyrimidine Biosynthesis dNTP Pool Hepatoma 3924A
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