Receptors, Neuroleptics and Dopamine Concentrations in Schizophrenia — Postmortem Studies of Human Brain Tissue
There is little doubt that biochemical investigation of human postmortem brain tissue has made a substantial contribution to the understanding and treatment of disease. It was as a direct result of the observation of a dopamine deficit in the corpus striatum of Parkinson’s disease patients that L-dopa was introduced and found to be so successful (Birkmayer and Hornykiewicz 1962). Unfortunately, such a valuable advance has yet to be made in other fields of neuropsychiatry, although recently some potentially important findings have been made towards our understanding of schizophrenia and the mechanisms of antipsychotic drugs.
KeywordsDopamine Schizophrenia Noradrenaline Catecholamine Haloperidol
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