Potential Medical Applications of the NMR Technique
In 1946 F. Bloch and E. M. Purcell conducted the first experiment in nuclear magnetic resonance (NMR), which in 1952 earned them the Nobel Prize. Since then, NMR has evolved from a method of measuring the magnetic properties of atomic nuclei to a powerful analytical tool yielding data on the structure and concentration of molecules. Through the use of modern computer systems, combined with technical advances in magnet design, it has been possible to improve the sensitivity of NMR measurements by several orders of magnitude. As a result, NMR has become suitable for the investigation of substances occurring in the biologic and medical concentration ranges, and it has stimulated particular interest through its application in intact biologic systems. Recent discoveries on the metabolism of healthy and diseased cells using NMR methods demonstrate the great potential of this experimental technique in clinical diagnostic medicine.
KeywordsPhosphorus Adenosine Triphosphate Myopathy Phosphocreatine
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