Antiprogestins

  • Thomas Rabe
  • Ludwig Kiesel
  • Benno Runnebaum
Part of the Current Topics in Neuroendocrinology book series (CT NEUROENDOCRI, volume 5)

Abstract

The most efficient methods of female contraception inhibit ovulation by disturbing the endogenous endocrine-regulating mechanisms, The ovulation inhibitors in current use depend on a constant level of active synthetic hormonal steroids during the menstrual cycle. This constant hormonal steroid concentration in the serum is achieved either by daily intake or by the use of long-acting depot injections. These methods combine a high efficiency with a relatively low percentage of side-effects. However, they almost always impair the cyclic physiology, thus giving rise to fears of long-term side-effects. Another disadvantage is that an almost continous intake of hormones is necessary, whereby significant quantities of hormones are ingested, although the use of new hormonal stereoids may slightly decrease the side-effects. Safety might be increased if the pharmacological inhibition of the menstrual cycle were reduced to a period of 1 or 2 days.

Keywords

Cortisol Prostaglandin Androgen Prolactin Thromboxane 

Abbreviations

hCG

human chorionic gonadotropin

GnRH

gonadotropin-releasing hormone

LH

luteinizing hormone

ACTH

adrenocorticotropin-releasing hormone

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Copyright information

© Spriger-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Thomas Rabe
  • Ludwig Kiesel
  • Benno Runnebaum
    • 1
  1. 1.Department of Gynecological EndocrinologyUniversity Hospital for WomanHeidelbergFederal Republic of Germany

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