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Multiple Mechanisms of Oncogene Activation in Viral and Nonviral Neoplasia

  • W. S. Hayward
Conference paper
Part of the Life Sciences Research Reports book series (DAHLEM, volume 30)


The oncogenic potential of a proto-oncogene can be “activated” by many different types of mutational events, including insertion of proviral control sequences, gene amplification, translocation, and point mutations within regulatory or coding sequences. The mechanisms by which a specific proto-oncogene can most readily be activated probably reflects unique structural and biological characteristics of the gene involved. The c-myc gene can be activated by a variety of mechanisms, but each appears to induce changes in expression of the gene. By contrast, members of the c-ras gene family appear to be preferentially activated by point mutations within coding sequences. Induction of a fully malignant state may require activation of more than one proto-oncogene and/or multiple mutational events within a single gene.


Long Terminal Repeat Mutational Event NIH3T3 Cell Burkitt Lymphoma Bovine Leukemia Virus 
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Copyright information

© Dr. S. Bernhard, Dahlem Konferenzen, Berlin 1985

Authors and Affiliations

  • W. S. Hayward
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

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