Circulating Mediators of the Adult Respiratory Distress Syndrome
The usual homeostatic response to injury is an inflammatory reaction. Entrapment and activation of platelets, as well as circulating and interstitial white blood cells, are events normally localized to the damaged site. In this region, there is generation and release of potent proteolytic enzymes, oxygen free radicals and other vasoactive agents. As with many homeostatic events, such as antibody formation, checks and feedback controls may not function properly, and the response itself may lead to injury, such as autoimmune disease. It is our thesis that under certain circumstances an inappropriate and generalized inflammatory reaction may be triggered by local injury, and that the resultant widespread release of vasotoxic agents may be responsible for the phenomena of multi-systems organ failure.
KeywordsPermeability Toxicity Pneumonia Superoxide Pancreatitis
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