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Expression of Cellular Oncogenes

  • R. Müller
  • I. M. Verma
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)

Abstract

Acutely oncogenic retroviruses induce a broad spectrum of malignant tumors (for review see Graf and Beug 1978; Teich et al. 1982). They all contain genomic sequences that are responsible for the induction of neoplastic transformation in vivo and in vitro. These sequences, termed viral oncogenes (v-onc), originated from the normal cellular genome (Bishop and Varmus 1982). Cellular homologs (c-one) of 20 different retroviral oncogenes have now been identified in a variety of species throughout the vertebrate phylum (Table 1) (Stehelin et al. 1976; Bishop and Varmus 1982; Bishop 1983), and in some instances even in invertebrates (Shilo and Weinberg 1982). Another category of c-one genes has been detected in the DNA of malignant cells by virtue of these genes’ ability to induce neoplastic transformation when “transfected” into a mouse fibroblastic cell line in vitro (for review see Cooper 1982). In several cases, however, it has been shown that such sequences are in fact the cellular homologs of v-onc genes (Der et al. 1982; Parada et al. 1982; Santos et al. 1982; McCoy et al. 1983; Shimizu et al. 1983c).

Keywords

Rous Sarcoma Virus Avian Myeloblastosis Virus Cellular Oncogene Avian Sarcoma Virus Murine Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abelson HT, Rabstein LS (1970) Lymphosarcoma: Virus-induced thymic-independent disease in mice. Cancer Res 30:2208–2212PubMedGoogle Scholar
  2. Abrams HD, Rohrschneider LR, Eisenman RN (1982) Nuclear location of the putative transforming protein of avian myelocytomatosis virus. Cell 29:427–439PubMedCrossRefGoogle Scholar
  3. Adams J, Gerondakis S, Webb E, Corcoran LM, Cory S (1983) Cellular myc gene is altered by chromosome translocation to immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphoma. Proc Natl Acad Sci USA 80:1982–1986PubMedCrossRefGoogle Scholar
  4. Adams JM, Gerondakis S, Webb E, Mitchell J, Bernard O, Cory S (1982) Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci USA 79:6966–6970PubMedCrossRefGoogle Scholar
  5. Alitalo K, Schwab M, Lin CL, Varmus HE, Bishop JM (1983) Homogenously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci USA 80:1707–1711PubMedCrossRefGoogle Scholar
  6. Andersen PR, Devare SG, Tronick SR, Ellis RW, Aaronson SA, Scolnick EM (1981) Generation of BALB/MuSV and Ha-MuSV by type C virus transduction of homologous transforming genes from different species. Cell 26:129–134PubMedCrossRefGoogle Scholar
  7. Anderson SJ, Furth M, Wolff L, Ruscetti SK, Sherr CJ (1982) Monoclonal antibodies to the transformation-specific glycoprotein encoded by the feline retroviral oncogene v-fms. J Virol 44:696–702PubMedGoogle Scholar
  8. Anderson SM, Hayward WS, Neel BG, Hanafusa H (1980) Avian erythroblastosis virus produces two mRNA’s. J Virol 36:676–683PubMedGoogle Scholar
  9. Banerji J, Olson L, Schaffner W (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729–744PubMedCrossRefGoogle Scholar
  10. Barbacid M, Beemon K, Devare SG (1980a) Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci USA 77:5158–5162PubMedCrossRefGoogle Scholar
  11. Barbacid M, Lauver AV, Devare SG (1980b) Biochemical and immunological characterization of polyproteins encoded for by the McDonough, Gardner-Amstein, and Snyder-Theilen strains of feline sarcoma virus. J Virol 33:196–207PubMedGoogle Scholar
  12. Barbacid M, Breitman ML, Lauver AV, Long LK, Vogt PK (1981) The transformation-specific protein of avian (Fujinami and PRC-II) and feline (Snyder-Theilen and Gardner-Amstein) sarcoma viruses are immunologically related. Virology 110:411–419PubMedCrossRefGoogle Scholar
  13. Barker PE, Ruddle FH, Verma IM (1983) Chromosomal assignment of human proto-oncogenes: c-fos is located on human chromosome 2. Proc Natl Acad Sci USA (in press)Google Scholar
  14. Barnekow A, Schartt M, Anders F, Bauer H (1982) Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein. Cancer Res 42:2429–2433PubMedGoogle Scholar
  15. Bishop JM (1981) Retrovims oncogenes. In: Brown DD (ed) Developmental biology using purified genes. Academic, New York, pp 515–524Google Scholar
  16. Bishop JM (1983) Cellular oncogenes and retroviruses. Ann Rev Biochem 52:301–354PubMedCrossRefGoogle Scholar
  17. Bishop JM, Varmus HE (1982) Functions and origins of retroviral transforming genes. In: Weiss R et al. (eds) Molecular biology of tumor viruses, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 999–1108Google Scholar
  18. Blair DG, Oskarsson TG, Wood WL, McClements PJ, Fischinger G, Vande Woude G (1981) Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis. Science 212:941–943PubMedCrossRefGoogle Scholar
  19. Boyle WJ, Kipsick JS, Reddy EP, Baluda MA (1983) Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue. Proc Natl Acad Sci USA 80:2834–2838PubMedCrossRefGoogle Scholar
  20. Brugge JS, Erikson RL (1977) Identification of a transformation-specific antigen induced by an avian sarcoma virus. Nature 269:346–348PubMedCrossRefGoogle Scholar
  21. Brugge JS, Collett MS, Siddiqui A, Marczynska M, Deinhardt F, Erikson RL (1979) Detection of the viral sarcoma gene products in cells infected with various strains of avian sarcoma virus and of a related protein in uninfected chicken cells. J Virol 29:1196–1203PubMedGoogle Scholar
  22. Bunte T, Greiser-Wilke I, Donner P, Moelling K (1982) Association of gap-myc proteins from avian myelocytomatosis virus wild-type and mutants with chromatin. The EMBO J 8:919–927Google Scholar
  23. Capon DJ, Seeburg PH, McGrath JP, Hayflick JS, Edman U, Levinson AD, Goeddel DV (1983) Activation of ki-ras-2 gene in human colon and lung carcinomas by two different point mutations. Nature 304:507–513PubMedCrossRefGoogle Scholar
  24. Chang EH, Furth ME, Scolnick EM, Lowy DR (1982 a) Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 297:479–483PubMedCrossRefGoogle Scholar
  25. Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR (1982 b) Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci USA 79:4848–4852PubMedCrossRefGoogle Scholar
  26. Chattopadhyay SK, Chang EH, Lander ML, Ellis RW, Scolnick EM, Lowy DR (1982) Amplification and rearrangement of onc genes in mammalian species. Nature 296:361–363PubMedCrossRefGoogle Scholar
  27. Chen ISY, Mak TW, O’Rear JJ, Temin HM (1982) Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol 40:800–811Google Scholar
  28. Chen ISY, Wilhelmsen KC, Temin HM (1983) Structure and expression of c-rel, the cellular homolog to the oncogene of Reticuloendotheliosis virus strain T. J Virol 45:104–113PubMedGoogle Scholar
  29. Chen JH (1980) Expression of endogenous avian myeloblastosis vims information in different chicken cells. J Virol 36:162–170PubMedGoogle Scholar
  30. Chen JH, Hayward WS, Moscovici C (1981) Size and genetic content of virus-specific RNA in myeloblasts transformed by avian myeloblastosis virus (AMY). Virology 110:128–136PubMedCrossRefGoogle Scholar
  31. Coffin JM, Varmus HE, Bishop FM, Essex M, Hardy WD, Martin GS, Rosenberg NE, Scolnick EM, Weinberg RA, Vogt PK (1981) Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol 40:953–957PubMedGoogle Scholar
  32. Colby W, Chen E, Smith D, Levinson A (1983) Identification and nucleitide sequence of a human locus homologous to v-myc oncogene of avian myelocytomatosis virus MC29. Nature 301:722–725PubMedCrossRefGoogle Scholar
  33. Collett MS, Erikson RL (1978) Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci USA 75:2021–2024PubMedCrossRefGoogle Scholar
  34. Collett MS, Brugge JS, Erikson RL (1978) Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product. Cell 15:1363–1369PubMedCrossRefGoogle Scholar
  35. Collett MS, Erikson E, Purchio AF, Brugge JS, Erikson RL (1979) A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. Proc Natl Acad Sci USA 76:3159–3163PubMedCrossRefGoogle Scholar
  36. Collins S, Groudine M (1982) Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature 298:679–681PubMedCrossRefGoogle Scholar
  37. Collins SJ, Groudine MT (1983) Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K562. Proc Natl Acad Sci USA 80:4813–4817PubMedCrossRefGoogle Scholar
  38. Cook WD (1982) Rapid thymomas induced by Abelson murine leukemia virus. Proc Natl Acad Sci USA 79:2917–2921PubMedCrossRefGoogle Scholar
  39. Cooper JA, Hunter T (1983) Regulation of cell growth and transformation by tyrosin-specific protein kinases: The search for important cellular substrate proteins. In: Vogt, Koprowski (eds) Current Topics in Immunology and Microbiology, Vol. 107 Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  40. Cooper GM (1982) Cellular transforming genes. Science 218:801–806CrossRefGoogle Scholar
  41. Cooper GM, Neiman PE (1980) Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature 287:656–659PubMedCrossRefGoogle Scholar
  42. Cooper GM, Okenquist S, Silverman L (1980) Transforming activity of DNA of chemically transformed and normal cells. Nature 289:418–421CrossRefGoogle Scholar
  43. Cotton PC, Brugge JS (1983) Neural tissues express high levels of the cellular src gene product pp60c-src. Mol Cell Biol 3:1157–1162PubMedGoogle Scholar
  44. Courtneidge SA, Levinson AD, Bishop JM (1980) The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci USA 77:3783–3787PubMedCrossRefGoogle Scholar
  45. Crews S, Barth R, Hood L, Prehn J, Calame K (1982) Mouse c-myc oncogne is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science 218:1319–1321PubMedCrossRefGoogle Scholar
  46. Curran T, Teich NM (1982) Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000 dalton phosphoprotein. J Virol 42:114–122PubMedGoogle Scholar
  47. Curran T, Peters G, Van Beveren C, Teich NM, Verma IM (1982) The FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol 44:674–682PubMedGoogle Scholar
  48. Curran T, Miller AD, Zokas FL, Verma IM (1984) Viral and cellular fos gene products are located in the nucleus. Cell 36:259–268PubMedCrossRefGoogle Scholar
  49. Dalla-Favera R, Gelmann EP, Gallo RC, Wong-Staal F (1981) A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus. Nature 292:31–35PubMedCrossRefGoogle Scholar
  50. Dalla-Favera R, Wong-Staal F, Gallo RC (1982 a) onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient. Nature 299:61–63CrossRefGoogle Scholar
  51. Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM (1982b) Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 79:7824–7827CrossRefGoogle Scholar
  52. Dalla-Favera R, Franchini G, Martinotti S, Wong-Staal F, Gallo RC, Croce CM (1982c) Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci USA 79:4714–4717CrossRefGoogle Scholar
  53. Dalla-Favera R, Gallo RC, Gialongo A, Cruce CM (1982d) Chromosomal localization of human homolog (c-sis) of the simian sarcoma virus onc gene. Science 218:686–688CrossRefGoogle Scholar
  54. DeFeo D, Gonda MA, Young HA, Chang EH, Lowy DR, Scolnick EM, Ellis RW (1981) Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci USA 78:3328–3332PubMedCrossRefGoogle Scholar
  55. de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 300:765–767PubMedCrossRefGoogle Scholar
  56. DeLarco JE, Todaro GJ (1978) Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA 75:4001–4005CrossRefGoogle Scholar
  57. De Martinville B, Giacalone J, Shih C, Weinberg RA, Francke U (1983) Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11. Science 219:498–501PubMedCrossRefGoogle Scholar
  58. Der CJ, Cooper GM (1982) Altered gene products are associated with activation of cellular rask genes in human lung and colon carcinomas. Cell 32:201–208CrossRefGoogle Scholar
  59. Der CJ, Krontiris TG, Cooper GM (1982) Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci USA 79:3637–3640PubMedCrossRefGoogle Scholar
  60. Devare SG, Reddy EP, Law JD, Robbins KC, Aaronson SA (1983) Nucleotide sequence of simian sarcoma virus genome : demonstration that its acquired cellular sequences encode the transforming gene product of p28sis. Proc Natl Acad Sci USA 80:731–735PubMedCrossRefGoogle Scholar
  61. Dhar R, Ellis RW, Shih TY, Oroszlan S, Shapiro B, Maizel J, Lowy D, Scolnick E (1982) Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. Science 217:934–937PubMedCrossRefGoogle Scholar
  62. Donner L, Fedele LA, Garon CF, Anderson SJ, Sherr CJ (1982 a) McDonough feline sarcoma virus: characterization of the molecularly cloned provirus and its feline oncogene (v-fms). J Virol 41:489–500PubMedGoogle Scholar
  63. Donner P, Greiser-Wilke I, Moelling K (1982 b) Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature 296:262–266PubMedCrossRefGoogle Scholar
  64. Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN (1983) Simian sarcoma virus onc gene, v-sis, is derived from gene (or genes) encoding a platelet-derived growth factor. Science 221:275–277PubMedCrossRefGoogle Scholar
  65. Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD (1984) Close similarity of epidermal growth factor and v-erb-B oncogene protein sequences. Nature 307:521–527PubMedCrossRefGoogle Scholar
  66. Ellis RW, DeFeo D, Shih TY, Gonda MA, Young HA, Tsuchida N, Lowy DR, Scolnick EM (1981) The p21 src genes of Harvey and Kirsten sarcoma viruses originate from diverent members of a family of normal vertebrate genes. Nature 292:506–511PubMedCrossRefGoogle Scholar
  67. Ellis RW, DeFeo D, Furth ME, Scolnick EM (1982) Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein. Mol Cell Biol 2:1339–1345PubMedGoogle Scholar
  68. Erikson J, Ar-Rushdi A, Drwinga HL, Nowell PC, Croce CM (1983) Transcriptional activation of translocated c-myc oncogene in Burkitt lymphoma. Proc Natl Acad Sci USA 80:820–824PubMedCrossRefGoogle Scholar
  69. Eva A, Robbins KC, Andersen PR, Srinivasan A, Tronick SR, Premkumar R, Ellmore NW, Galen AT, Lautenberger JA, Papas TS, Westin EH, Wong-Staal F, Gallo RC, Aaronson SA (1982) Cellular genes analogous to retoviral onc genes are transcribed in human tumour cells. Nature 295:116–119PubMedCrossRefGoogle Scholar
  70. Farber E, Cameron R (1980) The sequential analysis of cancer development. Adv Cancer Res 31:125–226PubMedCrossRefGoogle Scholar
  71. Feldman R, Wang E, Hanafusa H (1983) Cytoplasmic localization of the transforming protein of Fujinama sarcoma virus: salt-sensitive association with subcellular components. J Virol 45:782–791PubMedGoogle Scholar
  72. Finkel MP, Biskis BO (1968) Experimental induction of osteosarcomas. Prog Exp Tumor Res 10:72–111Google Scholar
  73. Finkel MP, Bistis BO, Jinkins PB (1966) Virus induction of osteosarcomas in mice. Science 151:698–701PubMedCrossRefGoogle Scholar
  74. Finkel MP, Reilly CA Jr, Biskis BO (1975) Viral etiology of bone cancer. Front Radiat Ther Oncol 10:28–39Google Scholar
  75. Franchini G, Even J, Sherr CJ, Wong-Staal F (1981) onc sequences (v-fes) of Synder-Theilen feline sarcoma virus are derived from noncontiguous regions of a cat cellular gene (c-fes). Nature 290:154–157PubMedCrossRefGoogle Scholar
  76. Frankel AE, Fischinger PJ (1976) Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus. Proc Natl Acad Sci USA 73:3705–3709PubMedCrossRefGoogle Scholar
  77. Frankel AE, Gilbert JH, Porsiz KG, Scolnick EM, Aaronson SA (1979) Nature and distribution of feline sarcoma virus nucleotide sequences. J Virol 30:821–827PubMedGoogle Scholar
  78. Frykberg L, Palmieri S, Beug H, Graf T, Hayman MJ, Vennstrom B (1983) Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell 32:227–238PubMedCrossRefGoogle Scholar
  79. Fung TYK, Lewis WG, Crittenden LB, Kung HJ (1983) Activation of cellular oncogene c-erb by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell 33:357–368PubMedCrossRefGoogle Scholar
  80. Garber EA, Kruger JG, Hanafusa H, Goldberg AR (1983) Only membrane-associated RSV src proteins have amino-terminally bound lipid. Nature 302:161–163PubMedCrossRefGoogle Scholar
  81. Gardner MB, Arnstein P, Rongey RW, Estes JD, Sarma PS, Rickard CF, Huebner RJ (1970) Experimental transmission of feline fibrosarcomas to cats and dogs. Nature 226:807–809PubMedCrossRefGoogle Scholar
  82. Gattoni S, Kirschmeier P, Weinstein IB, Escobedo J, Diana D (1982) Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells. Mol Cell Biol 2:42–51PubMedGoogle Scholar
  83. Gazdar AF, Chopra HC, Sarma PS (1972) Properties of a murine sarcoma virus isolated from a tumor arising in an NZW/NZB F1 hybrid mouse. I. Isolation and pathology of tumors induced in rodents. Int J Cancer 9:219–233PubMedCrossRefGoogle Scholar
  84. Gillies SD, Morrison SL, Oi VJ, Tonegawa S (1983) A tissue specific transcription enhancer is located in the major intron of rearranged immunoglobulin heavy chain gene. Cell 33:717–728PubMedCrossRefGoogle Scholar
  85. Goff SP, Gilboa E, Witte ON, Baltimore D (1980) Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell 22:777–785PubMedCrossRefGoogle Scholar
  86. Goff SP, D’Eustachio P, Ruddle FH, Baltimore D (1982) Chromosomal assignment of the endogenous protooncogene c-abl. Science 218:1317–1319PubMedCrossRefGoogle Scholar
  87. Gonda TJ, Sheiness DK, Fanshier L, Bishop JM, Moscovici C, Moscovici MG (1981) The genome and the intracellular RNAs of avian myeloblastosis virus. Cell 23:279–290PubMedCrossRefGoogle Scholar
  88. Gonda TJ, Sheiness DK, Bishop JM (1982 a) Transcripts from the cellular homolog of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol 2:617–624PubMedGoogle Scholar
  89. Gonda MA, Young HA, Elser JE, Rasheed S, Talmadge CB, Nagashima K, Li C-C, Gilden RV (1982 b) Molecular cloning, genomic analysis, and biological properties of rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus. J Virol 44:520–529PubMedGoogle Scholar
  90. Goubin G, Goldman DS, Luce J, Neiman PE, Cooper GM (1983) Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA. Nature 302:114–119PubMedCrossRefGoogle Scholar
  91. Goyette M, Petropoulos CJ, Shank PR, Fausto N (1983) Expression of a cellular oncogene during liver regeneration. Science 219:510–512PubMedCrossRefGoogle Scholar
  92. Graf T, Beug H (1978) Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochim Biophys Acta 516:269–299PubMedGoogle Scholar
  93. Graf T, Oker-Blom N, Todorov TG, Beug H (1979) Transforming capacities and defectiveness of avian leukemia viruses OKIO and E26. Virology 94:431–436CrossRefGoogle Scholar
  94. Graf T, von Kirchbach A, Beug H (1981) Characterization of the hematopoietic target cells of AEV, MC29 and AMV avian leukemia viruses. Exp Cell Res 131:331–343PubMedCrossRefGoogle Scholar
  95. Groffen J, Heisterkamp N, Grosveld F, Van de Van W, and Stephenson JR (1982) Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science 216:1136–1138PubMedCrossRefGoogle Scholar
  96. Hall A, Marshall CJ, Spurr NK, Weiss RA (1983) Identification of transforming gene in two human saracoma cell lines as a new member of the ras gene family located on chromosome 1. Nature 303:396–400PubMedCrossRefGoogle Scholar
  97. Hampe A, Laprerotte I, Galibert F, Fidele LA, Sherr CJ (1982) Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine specific protein kinase genes. Cell 30:775–785PubMedCrossRefGoogle Scholar
  98. Hann SR, Abrams HD, Rohrschneider LR, Eisenman RN (1983) Proteins encoded by v-myc and c-myc oncogenes : Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell 34:789–798PubMedCrossRefGoogle Scholar
  99. Hardy WJ (1980) The biology and virology of the feline sarcoma viruses. In: Hardy, WD Jr et al (eds) Feline leukemia virus. Elsevier/North Holland, New York, pp 79–118Google Scholar
  100. Harper ME, Franchini G, Love J, Simon MI, Gallo RC and Wong-Stall F (1983) Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. Nature 304:169–171PubMedCrossRefGoogle Scholar
  101. Harris LJ, Lang RB, Maren KE (1982) Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc Natl Acad Sci USA 79:4175–4179PubMedCrossRefGoogle Scholar
  102. Harvey JJ (1964) An unidentified virus which causes the rapid production of tumours in mice. Nature 204:1104–1105PubMedCrossRefGoogle Scholar
  103. Hayman MJ, Ramsay GM, Savin K, Kitchener G, Graf T, Beug H (1983) Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Cell 32:579–588PubMedCrossRefGoogle Scholar
  104. Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480PubMedCrossRefGoogle Scholar
  105. Heisterkamp N, Groffen J, Stephenson JR, Spurr NK, Goodfellow PN, Solomon E, Carritt B, Bodmer WF (1982) Chromosomal localization of human cellular homologues of two viral oncogenes. Nature 299:747–749PubMedCrossRefGoogle Scholar
  106. Heisterkamp N, Groffen J, Stephenson JR (1983 a) Isolation of v-fms and its cellular homolog. Virology 126:248–258PubMedCrossRefGoogle Scholar
  107. Heisterkamp N, Groffen J, Stephenson JR (1983 b) The human v-abl cellular homologue. J Mol Appl Genet 2:57–68PubMedGoogle Scholar
  108. Hoffman-Falk H, Einat P, Shilo B-Z, Hoffmann FM (1983) Drosophila melanogaster DNA clones homologous to vertebrate oncogenes: evidence for a common ancestor to the src and abl cellular genes. Cell 32:589–598PubMedCrossRefGoogle Scholar
  109. Hunter T, Sefton BM (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci USA 77:1311–1315PubMedCrossRefGoogle Scholar
  110. Jansen HW, Rückert B, Lurz R, Bister K (1983) Two unrelated cell-derived sequences in the genome of avian leukemia and carcinoma inducing retrovirus MH2. EMBO J 2:1969–1975PubMedGoogle Scholar
  111. Jansson M, Philipson L, Vennstrom B (1983) Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus. EMBO J 2:561–565PubMedGoogle Scholar
  112. Jolly DJ, Esty AC, Subramani S, Friedmann T, Verma IM (1983) Elements in long terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene. Nucleic Acids Res 11:1855–1872PubMedCrossRefGoogle Scholar
  113. Jones M, Bosselmann RA, Houtin VJF, Berub A, Fan H, Verma IM (1980) Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells. Proc Natl Acad Sci USA 77:2651–2655PubMedCrossRefGoogle Scholar
  114. Kawai S, Yoshida M, Segawa K, Sugiyama H, Ishizaki R, Toyoshima K (1980) Characterization of Y73, an avian sarcoma virus: A unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci USA 77:6199–6203PubMedCrossRefGoogle Scholar
  115. Kirsten WH, Mayer LA (1967) Morphologic responses to a murine erythroblastosis virus. J Natl Cancer Inst 39:311–335PubMedGoogle Scholar
  116. Kitamura N, Kitamura A, Toyoshima K, Hirayama Y, Yoshida M (1982) Avian sarcoma virus Y73 genome and structural similarity of its transforming gene product to that of Rous sarcoma virus. Nature 297:205–208PubMedCrossRefGoogle Scholar
  117. Klein G (1981) The role of gene dosage and genetic transpositions in carcinogenesis. Nature 294:313–318PubMedCrossRefGoogle Scholar
  118. Klein G (1983) Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Cell 32:311–315PubMedCrossRefGoogle Scholar
  119. Klempnauer K-H, Gonda TJ, Bishop JM (1982) Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenior c-myb: the architecture of a transduced oncogene. Cell 31:453–463PubMedCrossRefGoogle Scholar
  120. Klempnauer K-H, Ramsay G, Bishop JM, Moscovici G, Moscovici C, McGrath J, Levinson AD (1983) The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell 33:345–355PubMedCrossRefGoogle Scholar
  121. Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW (1983) Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 35:359–367PubMedCrossRefGoogle Scholar
  122. Krontiris TG, Cooper GM (1981) Transforming activity of human tumor DNAs. Proc Natl Acad Sci USA 78:1181–1184PubMedCrossRefGoogle Scholar
  123. Land H, Parada LF, Weinberg RA (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304:596–602PubMedCrossRefGoogle Scholar
  124. Langbeheim H, Shih TY, Scolnick EM (1980) Identification of a normal vertebrate cell protein related to the p21 src of Harvey murine sarcoma virus. Virology 106:292–300PubMedCrossRefGoogle Scholar
  125. Lee CK, Chan EW, Reilly CA Jr, Pahnke VA, Rockus G, Finkel MP (1979) In vitro properties of FBR murine osteosarcoma virus (40650). Proc Soc Exp Biol Med 162:214–220PubMedGoogle Scholar
  126. Levinson AD, Courtneidge SA, Bishop JM (1981) Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). Proc Natl Acad Sci USA 78:1624–1628PubMedCrossRefGoogle Scholar
  127. Levy JA, Hartley JW, Rowe WP, Huebner RJ (1973) Studies of FBJ osteosarcoma virus in tissue culture: I. Biologic characteristics of the “C”-type viruses. J Natl Cancer Inst 51:525–539PubMedGoogle Scholar
  128. Marcu KB, Harris LJ, Stanton LW, Erikson J, Watt R, Croce CM (1983) Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci USA 80:519–523PubMedCrossRefGoogle Scholar
  129. Mathey-Prevot B, Hanafusa H, Kawai S (1982) A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. Cell 28:897–906PubMedCrossRefGoogle Scholar
  130. McBride OW, Swan DC, Santos E, Barbacid M, Tronick SR, Aaronson SA (1982) Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11. Nature 300:773–774PubMedCrossRefGoogle Scholar
  131. McCoy MS, Toole JJ, Cunningham JM, Chang EH, Lowy DR, Weinberg RA (1983) Characterization of a human colon/lung carcinoma oncogene. Nature 302:79–81PubMedCrossRefGoogle Scholar
  132. McDonough SK, Larsen S, Brodey RS, Stock ND, Hardy WD Jr (1971) A transmissible feline fibrosarcoma of viral origin. Cancer Res 31:953–956PubMedGoogle Scholar
  133. McGrath JP, Capon DJ, Smith DH, Chen EY, Seeburg PH, Goeddel DV, Levinson AD (1983) Structure and organization of the human ki-ras proto-oncogene and related processed pseudogene. Nature 304:501–506PubMedCrossRefGoogle Scholar
  134. Miller AD, Curran T, Verma IM (1984) C-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene. Cell 36:51–60PubMedCrossRefGoogle Scholar
  135. Mitelman F, Levan G (1981) Clustering of aberrations to specific chromosomes in human neoplasma: IV. A survey of 1,871 cases. Hereditas 95:79–139PubMedCrossRefGoogle Scholar
  136. Moloney JB (1966) A virus-induced rhabdomyosarcoma of mice. Natl Cancer Inst Monogr 22:139–142PubMedGoogle Scholar
  137. Müller R (1983) Differential expression of cellular oncogenes during murine development and in teratocarcinoma cell lines. Cold Spring Harbor Conf Cell Prolif 10:451–468Google Scholar
  138. Müller R, Slamon DJ, Tremblay JM, Cline MJ, Verma IM (1982) Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature 299:640–644PubMedCrossRefGoogle Scholar
  139. Müller R, Verma IM, Adamson ED (1983a) Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J 2:679–684PubMedGoogle Scholar
  140. Müller R, Tremblay JM, Adamson ED, Verma IM (1983 b) Tissue and cell type-specific expression of two human c-onc genes. Nature 304:454–456PubMedCrossRefGoogle Scholar
  141. Müller R, Slamon DJ, Adamson ED, Tremblay JM, Müller DM, Cline MJ, Verma IM (1983c) Expression of c-onc genes c-ras Ki and c-fms during mouse development. Mol Cell Biol 3:1062–1069PubMedGoogle Scholar
  142. Murray MJ, Cunningham JM, Parada LF, Dantry F, Lebowitz P, Weinberg RA (1983) The HL60 transforming sequences: a ras oncogene coexisting with altered myc gene in hematopoietic tumors. Cell 33:749–757PubMedCrossRefGoogle Scholar
  143. Mushinski JF, Potter M, Bauer SR, Reddy EP (1983) DNA rearrangement and altered RNA expression of c-myb oncogene in mouse plasmacytoid lymphosarcomas. Science 220:795–798PubMedCrossRefGoogle Scholar
  144. Naharro G, Tronick SR, Rasheed S, Gardner MB, Aaronson SA, Robbins KC (1983) Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus : Genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes. J Virol 47:611–619PubMedGoogle Scholar
  145. Naharro G, Robbins KC, Reddy EP (1984) Gene product of v-fgr onc: Hybrid protein containing a portion of actin and a tyrosine-specific protein kinase. Science 223:63–66PubMedCrossRefGoogle Scholar
  146. Neel BG, Jhanwar SC, Chaganti RSK, Hayward WS (1982) Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci USA 79:7842–7846PubMedCrossRefGoogle Scholar
  147. Neuberger MS (1983) Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J 2:1373–1378PubMedGoogle Scholar
  148. Noori-Daloii MR, Swift RA, Kung H-J, Crittenden LB, Witter RL (1981) Specific integration of REV proviruses in avian bursal lymphomas. Nature 294:574–576PubMedCrossRefGoogle Scholar
  149. Oppermann H, Levinson AD, Varmus HE, Levintow L, Bishop JM (1979) Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci USA 76:1804–1808PubMedCrossRefGoogle Scholar
  150. Oskarsson M, McClements W, Blair DG, Maizel JV, Vande Woude F (1980) Properties of a normal. mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science 207:1222–1224PubMedCrossRefGoogle Scholar
  151. Papkoff J, Lai MH-T, Hunter T, Verma IM (1981) Analysis of the transforming gene product of Moloney murine sarcoma virus. Cell 27:109–119PubMedCrossRefGoogle Scholar
  152. Parada LF, Tabin CJ, Shih C, Weinberg RA (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297:474–478PubMedCrossRefGoogle Scholar
  153. Parker RC, Varmus HE, Bishop JM (1981) Cellular homolog (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. Proc Natl Acad Sci USA 78:5842–5846PubMedCrossRefGoogle Scholar
  154. Payne GS, Bishop JM, Varmus HE (1982) Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature 295:209–214PubMedCrossRefGoogle Scholar
  155. Perbal B, Baluda MA (1982) Avian myeloblastosis virus transforming gene is related to unique chicken DNA regions separated by at least one intervening sequence. J Virol 41:250–257PubMedGoogle Scholar
  156. Perry RP (1983) Consequences of myc invasion of immunoglobulin loci: facts and speculation. Cell 33:647–649PubMedCrossRefGoogle Scholar
  157. Peters RL, Rabstein LS, Van Vleck R, Kelloff GJ, Huebner RJ (1974) Naturally occurring sarcoma virus of the BALB/cCr mouse. J Natl Cancer Inst 53:1725–1729PubMedGoogle Scholar
  158. Ponticelli AS, Whitlock CA, Rosenberg N, Witte ON (1982) In vivo tyrosine phosphorylations of the Abelson virus transforming protein are absent in its normal cellular homolog. Cell 29:953–960PubMedCrossRefGoogle Scholar
  159. Prakash K, McBride OW, Swan DC, Devare SG, Tronick SR, Aaronson SA (1982) Molecular cloning and chromosomal mapping of a human locus related to the transforming gene of Moloney murine sarcoma virus. Proc Natl Acad Sci USA 79:5210–5214PubMedCrossRefGoogle Scholar
  160. Privalsky ML, Bishop JM (1982) Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide. Proc Natl Acad Sci USA 79:3958–3962PubMedCrossRefGoogle Scholar
  161. Pulciani S, Santos E, Lauver AV, Long LK, Aaronson SA, Barbacid M (1982) Oncogenes in solid human tumours. Nature 300:539–542PubMedCrossRefGoogle Scholar
  162. Purchio AF, Erikson E, Brugge JS, Erikson RL (1978) Identification of a polypeptide encoded by the avian sarcoma virus src gene. Proc Natl Acad Sci USA 75:1567–1571PubMedCrossRefGoogle Scholar
  163. Queen C, Baltimore D (1983) Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741–748PubMedCrossRefGoogle Scholar
  164. Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR (1983 a) Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci USA 80:4218–4222PubMedCrossRefGoogle Scholar
  165. Rapp UR, Reynolds FH Jr, Stephenson JR (1983b) New mammalian transforming retrovirus: Demonstration of a polyprotein gene product. J Virol 45:914–924PubMedGoogle Scholar
  166. Rasheed S, Gardner MB, Huebner RJ (1978) In vitro isolation of stable rat sarcoma viruses. Proc Natl Acad Sci USA 75:2972–2976PubMedCrossRefGoogle Scholar
  167. Radke K, Beug H, Kornfeld S, Graf T (1982) Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31:643–653PubMedCrossRefGoogle Scholar
  168. Rechavi G, Givol D, Canaani E (1982) Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element. Nature 300:607–611PubMedCrossRefGoogle Scholar
  169. Reddy EP, Reynolds RK, Santos E, Barbacid M (1982) A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature 300:149–152PubMedCrossRefGoogle Scholar
  170. Reynolds FH, Van de Ven WJM, Stephenson JR (1980) Abelson murine leukemia virus transformation-defective mutants with impaired P120-associated protein kinase activity. J Virol 36:374–386PubMedGoogle Scholar
  171. Robbins KC, Devare SG, Reddy EP, Aaronson SA (1982) In vivo identification of the transforming gene product of simian sarcoma virus. Science 218:1131–1133PubMedCrossRefGoogle Scholar
  172. Rohrschneider LR (1979) Immunofluorescence on avian sarcoma virus-transformed cells: Localization of the src gene product. Cell 16:11–24PubMedCrossRefGoogle Scholar
  173. Rohrschneider LR (1980) Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product. Proc Natl Acad Sci USA 77:3514–3518PubMedCrossRefGoogle Scholar
  174. Rohrschneider LR, Gentry LE (1983) Subcellular location of retroviral transforming proteins define multiple mechanism of transformation. Adv Cancer ResGoogle Scholar
  175. Roussel M, Saule S, Lagrou C, Rommens C, Beug H, Graf T, Stehelin D (1979) Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. Nature 281:452–455PubMedCrossRefGoogle Scholar
  176. Ruley HE (1983) Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature 304:602–606PubMedCrossRefGoogle Scholar
  177. Sakaguchi AY, Haylor SL, Shows TB, Toole JJ, McCoy M, Weinberg RA (1983) Human c-K-ras proto-oncogene on chromosome 12. Science 219:1081–1083PubMedCrossRefGoogle Scholar
  178. Santos E, Tronick SR, Aaronson SA, Pulciani S, Barbacid M (1982) T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature 298:343–347PubMedCrossRefGoogle Scholar
  179. Schwab M, Alitalo K, Varmus HE, Bishop JM, George D (1983) A cellular oncogene (c-Ki-ras) is amplified, overexpressed and located within keryotypic abnormalities in mouse adrenocortical tumor cells. Nature 303:497–501PubMedCrossRefGoogle Scholar
  180. Scolnick EM, Papageorge AG, Shih TY (1979) Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci USA 76:5355–5359PubMedCrossRefGoogle Scholar
  181. Scolnick EM, Weeks MD, Shih TY, Ruscetti SK, Dexter TM (1981) Markedly elevated levels of an endogenous sarc protein in a hematopoietic precursor cell line. Mol Cell Biol 1:66–74PubMedGoogle Scholar
  182. Sefton BM, Hunter T, Raschke WC (1981a) Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. Proc Natl Acad Sci USA 78:1552–1556PubMedCrossRefGoogle Scholar
  183. Sefton BM, Hunter T, Ball EH, Singer SJ (1981 b) Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell 24:165–174PubMedCrossRefGoogle Scholar
  184. Sefton BM, Trowbridge IS, Cooper JA, Scolnick EM (1982) The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid. Cell 31:465–474PubMedCrossRefGoogle Scholar
  185. Sheiness D, Bishop JM (1979) DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus. J Virol 31:514–521PubMedGoogle Scholar
  186. Sheiness DK, Hughes SH, Varmus HE, Stubblefied E, Bishop JM (1980) The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript. Virology 105:415–424PubMedCrossRefGoogle Scholar
  187. Shen-Ong GLC, Keath EJ, Piccoli SP, Cole MD (1982) Novel myc oncogene RNA from abortive immunoglobulin gene recombination in mouse plasmacytomas. Cell 31:443–452PubMedCrossRefGoogle Scholar
  188. Shibuya M, Hanafusa H (1982) Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming protein with transforming genes of other sarcoma viruses. Cell 30:787–795PubMedCrossRefGoogle Scholar
  189. Shibuya M, Hanafusa T, Hanafusa H, Stephenson JR (1980) Homology exists among the transforming sequences of avian and feline sarcoma virus. Proc Natl Acad Sci USA 77:6536–6540PubMedCrossRefGoogle Scholar
  190. Shibuya M, Hanafusa H, Balduzzi PC (1982) Cellular sequences related to three new onc genes of avian sarcoma virus (fps, yes and ros) and their expression in normal and transformed cells. J Virol 42:143–152PubMedGoogle Scholar
  191. Shi C, Ben-Zion S, Goldfarb MP, Dannenberg A, Weinberg RA (1979) Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci USA 76:5714–5718CrossRefGoogle Scholar
  192. Shih TY, Weeks MO, Young HA, Scolnick EM (1979) Identification of a sarcoma virus-encoded phosphoprotein in nonproducer cells transformed by Kirsten and Harvey murine sarcoma virus. Virology 96:64–79PubMedCrossRefGoogle Scholar
  193. Shih TY, Papageorge AG, Stokes PE, Weeks MO, Scolnick EM (1980) Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvex murine sarcoma virus. Nature 287:686–691PubMedCrossRefGoogle Scholar
  194. Shilo BZ, Weinberg RA (1981) DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci USA 78:6789–6792PubMedCrossRefGoogle Scholar
  195. Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparpowsky E, Goldfarb M, Wigler M (1983 a) Structure of c-K-ras gene of human lung carcinoma cell line calu-1. Nature 304:497–50PubMedCrossRefGoogle Scholar
  196. Shimizu K, Goldfarb M, Perucho M, Wigler M (1983 b) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci USA 80:383–387PubMedCrossRefGoogle Scholar
  197. Shimizu K, Goldfarb M, Suard Y, Perucho M, Li Y, Kamata T, Feramisco J, Stavnezer E, Fogh J, Wigler MH (1983 c) Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci USA 80:2112–2116PubMedCrossRefGoogle Scholar
  198. Snyder SP, Theilen GH (1969) Transmissible feline fibrosarcoma. Nature 221:1074–1075PubMedCrossRefGoogle Scholar
  199. Souza LM, Strommer JN, Hillyard RL, Komaromy MC, Baluda MA (1980) Cellular sequences are present in the presumptive avian myeloblastosis virus genome. Proc Natl Acad Sci USA 77:5177–5181PubMedCrossRefGoogle Scholar
  200. Spector DH, Baker B, Varmus HE, Bishop JM (1978 a) Characteristics of cellular RNA related to the transforming gene of avian sarcoma virus. Cell 13:381–386PubMedCrossRefGoogle Scholar
  201. Spector DH, Smith K, Padgett T, McCombe P, Roulland-Dussoix C, Moscovici C, Varmus HE, Bishop JE (1978 b) Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses. Cell 13:371–379PubMedCrossRefGoogle Scholar
  202. Stanton LW, Watt R, Marcu KB (1983) Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmocytomas. Nature 303:401–406PubMedCrossRefGoogle Scholar
  203. Stavnezer E, Gerhard DS, Binari RC, Balazs I (1981) Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virus. J Virol 39:920–934PubMedGoogle Scholar
  204. Stehelin D, Varmus HE, Bishop JM, Vogt PK (1976) DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260:170–173PubMedCrossRefGoogle Scholar
  205. Tabin CJ, Bradley SM, Bargmann I, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, Lowy DR, Chang EH (1982) Mechanism of activation of a human oncogene. Nature 300:143–149PubMedCrossRefGoogle Scholar
  206. Takeya T, Hanafusa H (1983) Structure and sequence of the cellular gene homologous to the RSC src gene and the mechanism for generating the transforming virus. Cell 32:881–890PubMedCrossRefGoogle Scholar
  207. Takeya T, Hanafusa H, Junghans RP, Ju G, Skalka AM (1981) Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog. Mol Cell Biol 1:1024–1037PubMedGoogle Scholar
  208. Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M (1982) Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature 300:762–765PubMedCrossRefGoogle Scholar
  209. Taub R, Kirsch I, Morton C, Lenoir C, Swan D, Tronick S, Aaronson S, Leder P (1982) Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 79:7837–7841PubMedCrossRefGoogle Scholar
  210. Teich NM, Wyke J, Mak T, Bernstein A, Hardy W (1982) Pathogenesis of retrovirus-induced disease. In : Weiss R et al (ed) RNA tumor viruses, molecular biology of tumor viruses, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 785Google Scholar
  211. Theilen GH, Zeigel RF, Twiehaus MJ (1966) Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens and Japanese quail. J Natl Cancer Inst 37:731–743PubMedGoogle Scholar
  212. Theilen GH, Gould D, Fowler M, Dungworth DI (1971) C-type virus in tumor tissue of a woolly monkey (Lagothrix spp) with fibrosarcoma. J Natl Cancer Inst 47:881–889PubMedGoogle Scholar
  213. Twardzik DR, Todaro GJ, Marquardt H, Reynolds FH Jr, Stephenson JR (1982) Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor. Science 216:894–897PubMedCrossRefGoogle Scholar
  214. Van Beveren C, van Straaten F, Galleshaw JA, Verma IM (1981) Nucleotide sequence of the genome of a murine sarcoma virus. Cell 27:97–108PubMedCrossRefGoogle Scholar
  215. Van Beveren C, van Straaten F, Curran T, Müller R, Verma IM (1983) Nucleotide sequence analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell 32:1241–1255PubMedCrossRefGoogle Scholar
  216. van Straaten F, Müller R, Curran T, Van Beveren C, Verma IM (1983) Nucleotide sequence of a human c-onc gene: deduced amino acid sequence of human c-fos protein. Proc Natl Acad Sci USA 80:3183–3187PubMedCrossRefGoogle Scholar
  217. Vennström B, Bishop JM (1982) Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell 28:135–143PubMedCrossRefGoogle Scholar
  218. Wang JYJ, Baltimore D (1983) Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: Expression and relationship to the viral sequence. Mol Cell Biol 3:773–779PubMedGoogle Scholar
  219. Wang L-H, Feldman R, Shibuya M, Hanafusa H, Notter MFD, Balduzzi PC (1981) Genetic structure, transforming sequences, and gene product of avian sarcoma virus URI. J Virol 40:258–267PubMedGoogle Scholar
  220. Wang L-H, Hanafusa H, Notter MFD, Balduzzi PC (1982) Genetic structure and transforming sequence of avian sarcoma virus UR2. J Virol 41:833–841PubMedGoogle Scholar
  221. Ward JM, Young DM (1976) Histogenesis and morphology of periosteal sarcomas induced by FBJ virus in NIH Swiss mice. Cancer Res 36:3985–3992PubMedGoogle Scholar
  222. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C-H, Huang JS, Dual TF (1983) Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304:35–39PubMedCrossRefGoogle Scholar
  223. Watt R, Stanton LW, Marcu KB, Gallo RC, Croces CM, Ravena G (1983) Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature 303:725–728PubMedCrossRefGoogle Scholar
  224. Westin EH, Gallo RC, Arya SK, Eva A, Souza LM, Baldua MA, Aaronson SA, Wong-Staal F (1982 a) Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci USA 79:2194–2198PubMedCrossRefGoogle Scholar
  225. Westin EH, Wong-Staal F, Gelmann EP, Dalla-Favera R, Papas TS, Lautenberger JA, Eva A, Reddy EP, Tronick SR, Aaronson SA, Gallo RC (1982 b) Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci USA 79:2490–2494PubMedCrossRefGoogle Scholar
  226. Willingham MC, Jay G, Pastan I (1979) Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell 18:125–134PubMedCrossRefGoogle Scholar
  227. Williamham MC, Pastan I, Shih TY, Scolnick EM (1980) Localization of the src gene product of the Harvey strain of MSV to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell 19:1005–1014CrossRefGoogle Scholar
  228. Witte ON, Rosenberg, Paskind M, Sheilds A, Baltimore D (1978) Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci USA 75:2488–2492PubMedCrossRefGoogle Scholar
  229. Witte ON, Rosenberg N, Baltimore D (1979 a) Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface. J Virol 31:776–784PubMedGoogle Scholar
  230. Witte ON, Rosenberg N, Baltimore D (1979 b) A normal cell protein cross-reactive to the major Abelson murine leukemia virus gene product. Nature 281:396–398PubMedCrossRefGoogle Scholar
  231. Witte ON, Dasgupta A, Baltimore D (1980 a) Abelson murine leukemia virus protein is phosphory- lated in vitro to form phosphotyrosine. Nature 283:826–831PubMedCrossRefGoogle Scholar
  232. Witte ON, Goff S, Rosenberg N, Baltimore D (1980 b) A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proc Natl Acad Sci USA 77:4993–4997PubMedCrossRefGoogle Scholar
  233. Wong TC, Lai MMC (1981) Avian reticuloendotheliosis virus contains a new class of oncogene of turkey origin. Virology 111:289–293PubMedCrossRefGoogle Scholar
  234. Yoshida M, Kawai S, Toyoshima K (1980) Uninfected avian cells contain structurally unrelated progenitors of viral sarcoma genes. Nature 287:653–654PubMedCrossRefGoogle Scholar
  235. Yoshida M, Kawai S, Toyoshima K (1981) Genome structure of avian sarcoma virus Y73 and unique sequence coding for polyprotein p90. J Virol 38:430–437PubMedGoogle Scholar
  236. Young HA, Shih TY, Scolnick EM, Rasheed S, Gardner MB (1979) Different rat-derived transforming retroviruses code for an immunologically related intracellular phosphoprotein. Proc Natl Acad Sci USA 76:3523–3527PubMedCrossRefGoogle Scholar
  237. Young HA, Rasheed S, Souder R, Benton CV, Henderson LE (1981) Rat sarcoma virus: Further analysis of individual viral isolates and the gene product. J Virol 38:286–293PubMedGoogle Scholar
  238. Yuasa Y, Srivastava SK, Dunn CY, Rhimm JS, Reddy EP, Aaronson SA (1983) Acquisition of transforming properties by alternative point mutations within c-bas/has human protooncogene. Nature 303:775–779PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • R. Müller
    • 1
  • I. M. Verma
    • 2
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany
  2. 2.Molecular Biology and Virology LaboratoryThe Salk InstituteSan DiegoUSA

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