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Betablocker und Lipidstoffwechsel pp 145–156Cite as

Betablocker versus Diuretika in der antihypertensiven Therapie: Beeinflussung des Lipid- und Glukosestoffwechsels

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Zusammenfassung

Mehrere Interventionsstudien haben überzeugend demonstriert, daß die Gesamt- Morbidität und -Mortalität an kardiovaskulären Erkrankungen bei Patienten mit essentieller Hypertonie durch antihypertensive Therapie gesenkt werden kann [1–4]. Bei genauerer Analyse der Ergebnisse stellt sich aber heraus, daß Herzin-suffizienz, cerebrovaskuläre Ereignisse und Nierenversagen bei den aktiv behan-delten Patienten zwar signifikant weniger häufig auftreten, die Rate an Myo-kardinfarkten dagegen nicht abnimmt. Dies gilt insbesondere für Patienten bis zum 50. Lebensjahr [3].

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Literatur

  1. McFate Smith W, Edlavitch SA, Krushat WM (1979) U. S. Public Health Service hospitals intervention trial in mild hypertension. In: Onesti G, Klimt CR (ed) Hypertension- determinants, complications and intervention. Grune and Straton, New York, p 381–399

    Google Scholar 

  2. Australian National Blood Pressure Study Management Committee. The Australian therapeutic trial in mild hypertension. (1980) Lancet 1: 1261–1267

    Google Scholar 

  3. Hypertension Detection and Follow-up Program Cooperative Group. (1979) Five-year findings of the hypertension detection and follow-up program. (1) Reduction in mortality of persons with high blood pressure, including mild hypertension. (2) Mortality by race, sex and age. Jama 242: 2562–2577

    Article  Google Scholar 

  4. Helgeland A (1980) Treatment of mild hypertension: A five-year controlled drug trial. The Oslo study. Am J Med 69: 725–732

    Article  PubMed  CAS  Google Scholar 

  5. Lowenstein J, Neusy AJ (1982) The biochemical effects of antihypertensive agents and the impact on atherosclerosis. J Cardiovasc Pharmacol 4 Suppl 2: 262–264

    Google Scholar 

  6. Day JL, Simpson N, Metcalfe J et al (1979) Metabolic consequences of atenolol and propranolol in treatment of essential hypertension. Br Med J 1: 77–80

    Article  PubMed  CAS  Google Scholar 

  7. Tanaka N, Sakaguchi S, Oshige K et al (1976) Effect of chronic administration of propranolol on lipoprotein composition. Metabolism 25: 1071–1075

    Article  PubMed  CAS  Google Scholar 

  8. Kristensen BØ (1981) Effect of long-term treatment with beta-blocking drugs on plasma lipids and lipoproteins. Br Med J 283: 191–192

    Article  CAS  Google Scholar 

  9. Lehtonen A, Viikari J (1979) Long-term effect of Sotalol on plasma lipids. Clin Sci 57: 405s–407s

    PubMed  Google Scholar 

  10. Bielmann P, Leduc G, Davignon J (1980) Bêta-bloquants sélectif (métoprolol) vs non- sélectif (propranolol) Effets comparés sur la composition des lipoprotéines plasmatiques et la pression sanguine. Union Med Can 109: 1734–1740

    PubMed  CAS  Google Scholar 

  11. Schauer I, Schauer U, Ruhling K et al (1980) The effect of propranolol treatment on total cholesterol, HDL cholesterol, triglycerides, postheparin lipolytic activity and lecithin: Cholesterol acyltransferase in hypertensive individuals. Artery 8: 146–150

    PubMed  CAS  Google Scholar 

  12. Leren P, Foss OP, Helgeland A etal (1981) Effects of pindolol and hydrochlorothiazide on blood lipids. The Oslo Study. Clin Trials J 18: 254–261

    Google Scholar 

  13. Leren P, Helgeland A, Holme I, Foss OP, Hjermann I, Lund-Larsen PG (1980) Effect of propranolol and prazosin on blood lipids. The Oslo Study. Lancet 11: 4–6

    Article  Google Scholar 

  14. England JDF, Simons LA, Gibson JC, et al (1980) The effect of metoprolol and atenolol on plasma high density lipoprotein levels in man. Clin Exp Pharmacol Physiol 7: 329–333

    Article  PubMed  CAS  Google Scholar 

  15. Ballantyne D, Ballantyne FC, McMurdo (1981) Effect of slow Oxprenolol and a combination of slow Oxprenolol and cyclopenthiazide on plasma lipoproteins. Atherosclerosis 39: 301–306

    Article  PubMed  CAS  Google Scholar 

  16. Eliasson K, Lis LE, Rössner S (1981) Serum lipoprotein changes during atenolol treatment of essential hypertension. Eur J Clin Pharmacol 20: 335–338

    Article  PubMed  CAS  Google Scholar 

  17. Ames RP, Hill P (1976) Increase in serum-lipids during treatment of hypertension with chlorthalidone. Lancet 1: 721–723

    Article  PubMed  CAS  Google Scholar 

  18. Gluck Z, Weidmann P, Mordasini R, et al (1979) Einfluß einer Diuretikatherapie auf die Serumlipoproteine: Ein unerwünschter Effekt? Schweiz Med Wochenschr 109: 104–108

    PubMed  CAS  Google Scholar 

  19. Goldman AI, Steele BW, Schnaper HW, et al (1980) Serum lipoprotein levels during chlorthalidone therapy. Jama 244: 1691–1695

    Article  PubMed  CAS  Google Scholar 

  20. Joos C, Kewitz H, Reinhold-Kourniati D (1980) Effects of diuretics on plasma lipoproteins in healthy men. Eur J Clin Pharmacol 17: 251–257

    Article  PubMed  CAS  Google Scholar 

  21. Ames RP, Hill P (1982) Improvement of glucose tolerance and lowering of glycohemoglobin and serum lipid concentrations after discontinuation of antihypertensive drug therapy. Circulation 65: 899–904

    Article  PubMed  CAS  Google Scholar 

  22. Röschlau P, Berat E, Gruber W (1974) Enzymatische Bestimmung des Gesamt-Cholesterin im Serum. Z Klin Chem Klin Biochem 12: 403–407

    PubMed  Google Scholar 

  23. Bucolo G, David H (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 19: 476–482

    PubMed  CAS  Google Scholar 

  24. Wieland H, Scidel D (1978) Fortschritte in der Analytik des Lipoproteinmusters. Innere Medizin 7: 290–300

    Google Scholar 

  25. Myers LH, Phillips NR, Havel RJ (1976) Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human serum lipoproteins. J Lab Clin Med 88: 491–505

    PubMed  CAS  Google Scholar 

  26. Schonfeld G, Bailey A, Steelman R (1978) Plasma apolipoproteins, A-I and A-II levels in hyperlipidemia. Lipids 13: 951–959

    Article  PubMed  CAS  Google Scholar 

  27. Ames RP, Hill P (1978) Raised serum lipid concentrations during diuretic treatment of hypertension: a study of predictive indexes. Clin Sci Mol Med 55: 311s–314s

    CAS  Google Scholar 

  28. Abraham CE, Huff TA, Cope ND, Wilson JB, Bransome ED, Huisman JHT (1978) Determination of the glycosylated hemoglobin ( Hb AI) with a new microcolumn procedure. Diabetes 27: 931

    PubMed  CAS  Google Scholar 

  29. Day JL, Metcalfe J, Simpson CN (1982) Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 284: 1145–1148

    Article  CAS  Google Scholar 

  30. Eisenberg S, Patsch JR, Olivecrona T, Gotto AM (1978) Effects of lipolysis on human lipid density lipoproteins (HDL). Circulation 58: suppl abstract 47

    Google Scholar 

  31. Tall AR, Small DM (1978) Plasma high density lipoproteins. N Engl J Med 299:1232– 1236

    Article  Google Scholar 

  32. McGonigle RJS, Williams L, Murphy MJ, Parsans V (1981) Labetalol and lipids. Lancet 1: 163

    Article  PubMed  CAS  Google Scholar 

  33. Hulley SB, Rosenman RN, Bawol RD, etal (1980) Epidemiology as a guide to clinical decisions. The association between triglyceride and coronary heart disease. N Engl J Med 302: 1383–1389

    Article  PubMed  CAS  Google Scholar 

  34. Böttcher CJF, Boelsma-van Houte E, Romeny-Wachter CC, Woodford FP, van Gent CM (1960) Lipid and fatty-acid composition of coronary and cerebral arteries at different stages of atherosclerosis. Lancet 2:1162–1166

    Article  Google Scholar 

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Authors
  1. K. O. Stumpe
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  2. H. M. Müller
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  3. G. Klautke
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  4. A. Overlack
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  5. R. Kolloch
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Klinikum der Universität Heidelberg, Bergheimer Straße 58, 6900, Heidelberg 1, Germany

    Gotthard Schettler  & Curt Diehm  & 

  2. Zentrallaboratorium der Medizinischen Einrichtungen der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Straße 33, 4400, Münster, Germany

    Gerd Assmann

  3. Medizinische Fakultät der Universität des Saarlandes, Medizin-Soziologie, Universitätskliniken, 6650, Homburg/Saar, Germany

    Joachim Moerchel M. A.

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© 1984 Springer-Verlag Berlin Heidelberg

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Stumpe, K.O., Müller, H.M., Klautke, G., Overlack, A., Kolloch, R. (1984). Betablocker versus Diuretika in der antihypertensiven Therapie: Beeinflussung des Lipid- und Glukosestoffwechsels. In: Schettler, G., Assmann, G., Diehm, C., Moerchel, J. (eds) Betablocker und Lipidstoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69675-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-69675-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69676-3

  • Online ISBN: 978-3-642-69675-6

  • eBook Packages: Springer Book Archive

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