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Microtubule Poisons

  • Chapter
Microtubules

Abstract

A small number of chemicals, principally colchicine and some of its derivatives, the Vinca alkaloids, and the benzimidazole compounds, bind specifically to tubulin and prevent its assembly into MT. As these poisons play a fundamental role in all MT research, it is now indispensible to study their action, and that of other chemicals with more or less similar actions. It is important to remember that several pharmalogical effects of these drugs are unrelated to MT poisoning. One method for ascertaining any relation to tubulins and MT is to compare the effects of various drugs, and also of other means of affecting MT, such as cold, high hydrostatic pressures, or deuterium oxyde.

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Dustin, P. (1984). Microtubule Poisons. In: Microtubules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69652-7_8

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