Abstract
When Klinefelter et al. originally described their syndrome in 1942, they made no reference to osteoporosis. Since that time it has frequently been claimed that osteoporosis is a factor of the syndrome, but there is a shortage of hard data on the subject. It is probably true that osteoporosis is associated with hypogonadism in men (Jackson 1958), but even this association is poorly defined. In fact, osteoporosis in the male has received much less attention than osteoporosis in the female and is that much less well understood.
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References
Aaron J (1976) Histology and micro-anatomy of bone. In: Nordin BEC (ed) Calcium phosphate and magnesium metabolism. Churchill Livingstone, Edinburgh, pp 298–356
Aaron J, Sagreiya K, Carter D, Nordin BEC (to be published) The determinants of bone volume in young adults. In: Clinical disorders of bone and mineral metabolism
Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Bailliere, Tindall and Cox, London
Bergman I, Loxley R (1970) The determination of hydroxyproline in urine hydrolysates. Clin Chim Acta 17:347–349
Connerty HV, Briggs AR (1966) Determination of serum calcium by means of orthocresolph-thalein complexone. Am J Clin Pathol 45:290–296
Crilly RG, Francis RM, Nordin BEC (1981) Steroid hormones, ageing and bone. Clin Endocrinol Metab 10:115–139
Delmas P, Meunier PJ (1981) L’osteoporose au cours du syndrome de Klinefelter. Nouv Presse Med 10:687–690
Foresta C, Ruzza G, Mioni R, Meneghello A, Baccichetti C (1983) Testosterone and bone loss in Klinefelter syndrome. Horm Metab Res 15:56–57
Francis RM, Peacock M, Thompson J (1983) Hypogonadism and osteoporosis. Clin Sci 64:38
Jackson WPV (1958) Osteoporosis of unknown cause in younger people. J Bone Joint Surg [Br] 40:420–441
Klinefelter HF Jr, Reifenstein EC Jr, Albright F (1942) Syndrome characterized by gynecomastia, aspermatogenesis without a-leydigism, and increased excretion of follicle-stimulating hormone. J Clin Endocrinol 2:615–627
Nordin BEC, Aaron J, Speed R, Crilly RG, (1981 a) Bone formation and resorption as the determinants of trabecular bone volume in post-menopausal osteoporosis. Lancet II: 277–280
Nordin BEC, Marshall DH, Francis RM, Crilly RG (1981b) The effects of sex steroid and corticosteroid hormones on bone. J Steroid Biochem 15:171–174
Nordin BEC, Aaron J (1982) A new model for osteoporosis. In: Norman AW, Schaefer K, Herroth DV, Grigoleit H-G (eds) Vitamin D, chemical, biochemical and clinical endocrinology of calcium metabolism. Walter de Gruyter, Berlin New York, pp 921–923
Nordin BEC, Aaron J, Speed R (1982) A new model for osteoporosis. In: Menczel J, Robin GC, Makin M, Steinberg R, (eds) Osteoporosis. Wiley, New York, pp 21–25
Nordin BEC, Aaron J, Makins N, Francis RM, Sagreiya K (1983) Bone formation and resorption in postmenopausal osteoporosis. In: Dixon AStJ, Russell REG, Stamp TCB (eds) Osteoporosis, a multidisciplinary problem. R Soc Med Internat Congress and Symposium Series No. 55. Academic Press and R Soc Med, London, pp 162–171
Smith DAS, Walker MS (1977) Changes in plasma steroids and bone density in Klinefelter’s Syndrome. Caicif Tissue Res 22:225–229
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© 1984 Springer-Verlag Berlin · Heidelberg
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Horowitz, M. et al. (1984). Osteoporosis and Klinefelter’s Syndrome. In: Bandmann, HJ., Breit, R., Perwein, E. (eds) Klinefelter’s Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69644-2_8
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DOI: https://doi.org/10.1007/978-3-642-69644-2_8
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