XXY Syndrome in Domestic Animals: Homologues to Klinefelter’s Syndrome in Man

  • G. W. Rieck


The detection, exploration, and utilization of animal models in human nosology is a prominent area of cooperation between human medicine and veterinary medicine. Of special usefulness to human medicine is the experimental animal which develops symptoms of syndromes homologous to those observed in human beings, and which thus appears to be suitable for diagnostic, etio-logic, pathogenetic, and therapeutic studies. Veterinary medicine, on the other hand, is primarily interested in the species-specific variations of pathological developments. In the field of chromosome research such investigations have created the special type of clinical research known as “comparative cytogenetics.” It is no accident that T. C. Hsu entitled his report on the history of cytogenetics (1979) “Human and Mammalian Cytogenetics”‘, again, “Mammals for Cytogenetics” was the title given to the chapter examining the role of mammals in chromosomal research. In this chapter, however, there was no mention of domestic animals.


Domestic Animal Barr Body Male Pseudohermaphrodite Leydig Cell Hyperplasia Meiotic Disturbance 
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  1. Auslitz HJ (1974) Der bovine Hypogonadismus — das XXY-Syndrom beim Rind. Thesis, University of GießenGoogle Scholar
  2. Basrur PK, Kanagawa H, Gilman JPW (1969) An equine intersex with unilateral gonadal agenesis. Can J Comp Med 33:297–306PubMedGoogle Scholar
  3. Biggers JD, McFeely RA (1966) Intersexuality in domestic mammals. In: McLaren A (ed) Advances in reproductive physiology, vol. 1. Logos Press, London, pp 29–59Google Scholar
  4. Bouters R, Vandeplassche M (1972) Cytogenetics and reproduction in large domestic animals. VII. Internationaler Kongress für tierische Fortpflanzung und Haustierbesamung, Munich, vol II, pp 1091–1094Google Scholar
  5. Bouters R, Vandeplassche M, De Moor A (1972) An intersex (male pseudohermaphrodite) horse with 64 XX/65 XXY mosaicism. Equine Vet J 4:150–153PubMedCrossRefGoogle Scholar
  6. Breeuwsma AJ (1968) A case of XXY sex chromosome constitution in an intersex pig. J Re-prod Fertil 16:119–120CrossRefGoogle Scholar
  7. Bruère AN, Marshall RB, Ward DPJ (1969) Testicular hypoplasia and XXY sex chromosome complement in two rams: The ovine counterpart of Klinefelter’s syndrome in man. J Re-prod Fertil 19:103–108CrossRefGoogle Scholar
  8. Centerwall WR, Benirschke K (1973a) Male tortoiseshell and calico (T-C) cats. Animal models of sex chromosome mosaics, aneuploids, polyploids, and chimerics. J Hered 64:272–278PubMedGoogle Scholar
  9. Centerwall WR, Benirschke K (1973b) An animal model for XXY Klinefelter’s syndrome in man. 4th Int Conf Birth Defects, ViennaGoogle Scholar
  10. Clough E, Pyle RL, Hare WCD, Kelly DF, Patterson DF (1970) An XXY sex-chromosome constitution in a dog with testicular hypoplasia and congenital heart disease. Cytogenetics 9:71–77PubMedCrossRefGoogle Scholar
  11. Dunn HO, Vaughan JT, McEntee K (1974) Bilaterally cryptorchid stallion with female karyotype. Cornell Vet 64: 265–275PubMedGoogle Scholar
  12. Dunn HO, Lein DH, McEntee K (1980) Testicular hypoplasia in a Hereford bull with 61, XXY karyotype: The bovine counterpart of human Klinefelter’s syndrome. Cornell Vet 70:137–146PubMedGoogle Scholar
  13. Ford CE, Jones KW, Miller OJ, Mittwoch U, Penrose LS, Ridler M, Shapiro A (1959) The chromosomes in a patient showing both mongolism and the Klinefelter syndrome. Lancet 709–710Google Scholar
  14. Fretz PB, Hare WCD (1976) A male pseudohermaphrodite horse with 63X07/64XX/65XXY mixoploidy. Equine Vet J 8:130–132PubMedCrossRefGoogle Scholar
  15. Gluhovschi N, Bistriceanu M, Suciu A, Bratu M (1970) A case of intersexuality in the horse with type 2 A + XXXY chromosome formula. Br Vet J 126:522–525PubMedGoogle Scholar
  16. Hageltorn M, Gustavsson I (1980) XXY-trisomy identified by banding techniques in a male tortoise shell cat. In: Hageltorn M, Identification of individual chromosomes and some spontaneous aberrations in domestic animals. PhD Thesis, University of UppsalaGoogle Scholar
  17. Hancock JL, Daker MG (1981) Testicular hypoplasia in a boar with abnormal sex chromosome constitution (39 XXY). J Reprod Fertil 61:395–397PubMedCrossRefGoogle Scholar
  18. Harvey MJA (1968) A male pig with an XXY/XXXY sex chromosome complement. J Reprod Fertil 17:319–324PubMedCrossRefGoogle Scholar
  19. Herzog A, Höhn H, Olyschläger F (1982) Autosomale Trisomie bei Kälbern mit allgemeiner Unterentwicklung (Nanismus). Dtsch Tierärztl Wochenschr 89:400–403PubMedGoogle Scholar
  20. Hsu TC (1979) Human and mammalian cytogenetics. A historical perspective. Springer, New York Heidelberg BerlinGoogle Scholar
  21. Jacobs PA, Strong JA (1959) A case of human intersexuality having a possible XXY sex-determining mechanism. Nature 183:302–303PubMedCrossRefGoogle Scholar
  22. Jones TC (1969) Anomalies of sex chromosomes in tortoiseshell male cats. In: Benirschke K (ed) Comparative mammalian cytogenetics. Springer, Berlin Heidelberg New York, pp 414–433Google Scholar
  23. Karg H, Schams D (1969) Radioimmunologische Bestimmung der Hypophysenhormone ICSH und Prolaktin im Blut männlicher Rinder. Berl Münch Tierärztl Wochenschr 82:471–473PubMedGoogle Scholar
  24. Lenz W, Nowakowski H, Prader A, Schirren C (1959) Die Ätiologie des Klinefelter-Syndroms. Ein Beitrag zur Chromosomenpathologie beim Menschen. Schweiz Med Wochenschr 89:727–731PubMedGoogle Scholar
  25. Logue DN, Harvey MJA, Munro CD, Lennox B (1979) Hormonal and histological studies in a 61XXY bull. Vet Rec 104:500–503PubMedCrossRefGoogle Scholar
  26. Lojda L, Havránková J (1975) Erbliche Hodenhypoplasie in der Nachkommenschaft eines Bullen mit Chromosomenmosaik 60,XY/61,XXY/59,X0. 2. Europäisches Kolloquium über Zytogenetik (Chromosomenpathologie) in Veterinärmedizin, Tierzucht und Säugetierkunde, Gießen, pp 193–198Google Scholar
  27. McFeely RA (1975) A review of cytogenetics in equine reproduction. J Reprod Fertil [Suppl] 23:371–374Google Scholar
  28. Rieck GW (1970) Das XXY-Syndrom beim Rind (Boviner Hypogonadismus). 1. Europäisches Kolloquium über Zytogenetik (Chromosomenpathologie) in Veterinärmedizin und Säugetierkunde, Gießen. Gießener Beitr Erbpath Zuchthyg Sonderheft 1:138–145Google Scholar
  29. Rieck GW, Höhn H, Herzog A (1969) Hypogonadismus, intermittierender Kryptorchismus und segmentäre Aplasie der Ductus Wolffii bei einem männlichen Rind mit XXY-Gonosomen-Konstellation bzw. XXY-XX-/XY-Gonosomen-Mosaik. Dtsch Tierärztl Wochenschr 76:133–138PubMedGoogle Scholar
  30. Rieck GW, Höhn H, Herzog A (1970) X-Trisomie beim Rind mit Anzeichen familiärer Disposition für Meiosestörungen. Cytogenetics 9:401–409PubMedCrossRefGoogle Scholar
  31. Russell LB, Chu EHY (1961) An XXY male in the mouse. Proc Natl Acad Sci USA 47:571–575PubMedCrossRefGoogle Scholar
  32. Thuline HC, Norby DE (1961) Spontaneous occurrence of chromosome abnormality in cats. Science 134:554–555PubMedCrossRefGoogle Scholar
  33. Toyama Y (1974) Sex chromosome mosaicisms in five swine intersexes. Jap J Zootech Sci 45:551–557Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • G. W. Rieck
    • 1
  1. 1.Institut für Zuchthygiene und veterinärmedizinische GenetikJustus-Liebig-Universität GiessenGiessenGermany

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