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Spermatological Investigations in Men with Klinefelter’s Syndrome

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Klinefelter’s Syndrome

Abstract

Klinefelter’s syndrome is usually characterized by absolute infertility. Since the diagnosis is made possible by determination of positive sex chromatin and by chromosomal analysis yielding the karyotype 47,XXY, semen examination is normally neglected and limited to the verification of azoospermia. In addition, in some subjects even the collection of semen is not possible owing to ejacula-tory impotence. Therefore, little is known about the different components of the seminal plasma in Klinefelter patients.

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References

  • Acre B, Padrón S (1980) Spermatogenesis in Klinefelter’s syndrome. Reproduction 4:177–184

    Google Scholar 

  • Becker KL (1972) Clinical and therapeutic experience with Klinefelter’s syndrome. Fertil Steril 23:568–578

    PubMed  CAS  Google Scholar 

  • Bunge RG, Bradbury JT (1956) Newer concepts of the Klinefelter syndrome. J Urol 76:758–765

    PubMed  Google Scholar 

  • Cooman SD, Gilliaux P, Thomas K (1983) Immunoreactive relaxin-like substance in human split ejaculate. Fertil Steril 39:111–113

    PubMed  Google Scholar 

  • Cornwell JG, Herrmann W (1958) Intersexuality in mentally deficient patients. Acta Endocrinol 27:369–376

    PubMed  CAS  Google Scholar 

  • Court-Brown WM, Mantle DJ, Buckton KE, Tough IM (1964) Fertility in a XY/XXY male married to a translocation heterozygote. J Med Genet I:35–38

    Article  Google Scholar 

  • Cushman DW, Cheung HS (1971) Concentrations of angiotensin-converting enzyme in tissues of the rat. Biochem Biophys Acta (Amst) 250:261–265

    CAS  Google Scholar 

  • Cushman DW, Cheung HSS (1971) Spectrophotometry assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20:1637–1648

    Article  CAS  Google Scholar 

  • Depierre D, Roth M (1974) Purification of angiotensin-converting enzyme from human seminal plasma. Experimentia 30:686

    Google Scholar 

  • Dowling RH, Knox SJ (1963) Transvestism and fertility in a chromosomal mosaic. Postgrad Med J 39:665–669

    Article  PubMed  CAS  Google Scholar 

  • Eberhagen D (1973) Klinische Chemie und Hämatologie. Urban Schwarzenberg, Munich Berlin Vienna

    Google Scholar 

  • Eliasson R (1971) Standards for investigation of human semen. Andrologia 3:49–64

    Article  Google Scholar 

  • Essig M, Schoenfeld C, Amelar RD, Dubin L, Weiss G (1982) Stimulation of human sperm motility by relaxin. Fertil Steril 38:339–343

    PubMed  CAS  Google Scholar 

  • Ferguson-Smith MA, Munro JB (1958) Spermatogenesis in the presence of female nuclear sex. Scott Med J 3:39–42

    PubMed  CAS  Google Scholar 

  • Ferguson-Smith MA, Lennox B, Mack WS, Stewart JSS (1957) Klinefelter’s syndrome. Frequency and testicular morphology in relation to nuclear sex. Lancet II:167–169

    Article  Google Scholar 

  • Fink E, Schill W-B (1983) Tissue kallikrein in human seminal plasma. In: Fritz H, Back N, Dietze G, Haberland GL (eds) Kinins-III. Plenum, New York London, pp 1175–1180

    Google Scholar 

  • Forti G, Giusti G, Borghi A, Pazzagli M, Fiorelli G, Cabresi E, Mannelli M, Bassi F, Gignotti P, Fusi S, Serio M (1978) Klinefelter’s syndrome: a study of its hormonal plasma pattern. J Endocrinol Invest 2:149–154

    Google Scholar 

  • Foss GL, Lewis FJW (1971) A study of four cases with Klinefelter’s syndrome, showing motile spermatozoa in their ejaculates. J Reprod Fertil 25:401–408

    Article  PubMed  CAS  Google Scholar 

  • Foss GL, Bell ET, Lewis FJW, Loraine JA, Pollard BR (1967) The effect of clomiphene on spermatogenesis and hormone excretion in a patient with Klinefelter’s syndrome. J Reprod Fertil 13:315–320

    Article  PubMed  CAS  Google Scholar 

  • Frick J (1980) Hormonbestimmungen in der Andrologie. Andrologia 12:211–218

    Article  PubMed  CAS  Google Scholar 

  • Fritz H, Arnhold M, Förg-Brey B, Zaneveld LJD, Schumacher GFB (1972) Verhalten der “Chymotrypsin-ähnlichen” Proteinase aus Humansperma gegenüber Protein-Proteinase-Inhibitoren. Hoppe-Seyler’s Z Physiol Chem 353:1651–1653

    Article  PubMed  CAS  Google Scholar 

  • Futterweit W (1967) Spermatozoa in seminal fluid of a patient with Klinefelter’s syndrome. Fertil Steril 18:492–496

    PubMed  CAS  Google Scholar 

  • Genov DT, Zlatkov NB (1971) Eisen, eisenbildende Kapazität und Transferrin im Spermaplasma. Andrologie 3:155–160

    Google Scholar 

  • Gomez-Acebo J, Parrilla R, Abrisqueta JA, Pozuelo V (1968) Fine structure of spermatogenesis in Klinefelter syndrome. J Clin Endocrinol 28:1287–1294

    Article  CAS  Google Scholar 

  • Grabski J, Pusch H, Schirren C, Passarge E, Held K, Bartsch W, Wernicke J (1979) Klinische, hormonale, histologische und chromosomale Untersuchungen beim Klinefelter-Syndrom. Andrologia 11:182–196

    Article  PubMed  CAS  Google Scholar 

  • Grumbach MM, Blanc WA, Engle ET (1957) Sex chromatin pattern in seminiferous tubule dysgenesis and other testicular disorders: relationship to true hermaphrodism and to Klinefelter’s syndrome, with a review of gonadal ontogenesis. J Clin Endocrinol Metab 17:703–730

    Article  PubMed  CAS  Google Scholar 

  • Harrer G (1958) Kasuistischer Beitrag zur Pathogenese des Klinefelter Syndroms. Wien Klin Wochenschr 70:280–281

    PubMed  CAS  Google Scholar 

  • Heite HJ, Wetterauer K (1979) Zur Kenntnis der sauren Prostataphosphatase im Seminalplasma — Bestimmungsmethode und diagnostische Bedeutung. Andrologia 11:113–122

    Article  PubMed  CAS  Google Scholar 

  • Hohlbrugger G, Schweisfurth H, Dahlheim H (1982) Angiotensin I converting enzyme in rat testis, epididymis and vas deferens under different conditions. J Reprod Fertil 65:97–103

    Article  PubMed  CAS  Google Scholar 

  • Holmes SD, Lipshultz LJ, Smith RG (1982) Transferrin and gonadal dysfunction in man. Fertil Steril 38:600–604

    PubMed  CAS  Google Scholar 

  • Holub D, Grumbach MM, Jailer JW (1958) Seminiferous tubule dysgenesis (Klinefelter’s syndrome) in identical twins. J Clin Endocrinol Metab 18:1358–1368

    Article  Google Scholar 

  • Ishibe T, Nihira H, Kadotani T, Ohama K (1971) Enzyme activities in the seminal plasma of patients with sex chromosome abnormalities. Fertil Steril 22:774–777

    PubMed  CAS  Google Scholar 

  • Kaplan H, Aspillaga M, Shelley TF, Gardner LJ (1963) Possible fertility in Klinefelter’s syndrome. Lancet I:506

    Article  Google Scholar 

  • Kent JR, Suryanaryana BV, Hill M (1969) Sex hormone effect upon acid phosphatase content of human seminal and prostatic fluid. Invest Urol 7:250–256

    PubMed  CAS  Google Scholar 

  • Kimmig J, Steeno O, Schirren C (1967) Ergebnisse der modernen biochemischen Forschungen auf dem Gebiet der Andrologie. Internist 8:25–34

    PubMed  CAS  Google Scholar 

  • Krassnigg F, Töpfer-Petersen E, Frick J, Schill W-B (1984) Human seminal plasma relaxin and its relation to some semen parameters. Proc World Congress on Fertil Steril, Dublin 1983 in press

    Google Scholar 

  • Laron Z, Dickermann Z, Zamir R, Galatzer A (1982) Paternity in Klinefelter’s syndrome — a case report. Arch Androl 8:149–151

    Article  PubMed  CAS  Google Scholar 

  • Lewin LM, Shalev DP, Weissenberg R, Soffer Y (1981) Carnitine and acylcarnitines in semen from azoospermic patients. Fertil Steril 36:214–218

    PubMed  CAS  Google Scholar 

  • Loumaye E, Decooman S, Thomas K (1980) Immunoreactive relaxin-like substance in human seminal plasma. J Clin Endocrinol Metab 50:1142–1143

    Article  PubMed  CAS  Google Scholar 

  • Mann K, Goring W, Lipp W, Keipert B, Karl HJ, Geiger R, Fink E (1980) Radioimmunoassay of human urinary kallikrein. J Clin Chem Clin Biochem 18:395–401

    PubMed  CAS  Google Scholar 

  • Mauss J, Börsch G, Török L (1974) Differential diagnosis of low or absent seminal fructose in man. Fertil Steril 25:411–415

    PubMed  CAS  Google Scholar 

  • Mauss J, Neumann R, Moll B, Bartsch-Sandhoff M (1977) Oligozoospermie bei Klinefelter Syndrom. Hautarzt 28:260–261

    PubMed  CAS  Google Scholar 

  • Menchini-Fabris GF, Izzo PL, Bartelloni M, Meschini P, Canale D (1983) The epididymal function. In: Harrison RF, Bonnar J, Thompson W (eds) Fertility and Sterility. Proc XIth World Congress Fertil Steril, Dublin 1983. MTP Press, Lancester Boston The Hague Dordrecht, pp. 245–253

    Google Scholar 

  • Moon KH, Osborn RH, Yannone ME, Bunge RG (1968) Seminal fructose and hormonal studies in Klinefelter’s syndrome. Invest Urol 6:179–182

    PubMed  CAS  Google Scholar 

  • Moon KH, Bunge RG (1970) Observations on the biochemistry of human semen. 4. Cholesterol. Fertil Steril 21:80–83

    PubMed  CAS  Google Scholar 

  • Moon KH, Bunge RG (1970) Observations on the biochemistry of human semen: 5. Protein. Fertil Steril 21:220–221

    PubMed  CAS  Google Scholar 

  • Mor C, Ben-Bassat M, Leiba S (1982) Leydig’s and Sertoli cells. Their fine structures in three cases of Klinefelter’s syndrome. Arch Pathol Lab Med 106:228–231

    PubMed  CAS  Google Scholar 

  • Nennstiel H-J, Alich R (1969) Fructosebestimmung im Ejakulat mittels Mikrolitersystem. Ärztl Lab 15:197–198

    CAS  Google Scholar 

  • Niermann H (1962) Spermiogenese beim Klinefelter-Syndrom. Z Menschl Vererb- und Konstitutionslehre 36:236–241

    CAS  Google Scholar 

  • O’Byrne EM, Steinitz GB (1976) Radioimmunoassay (RIA) of relaxin in serum of various species using an antiserum to porcine relaxin. Proc Soc Exp Biol Med 152:272–276

    PubMed  Google Scholar 

  • Overzier C (1964) Intersex. Lancet 1:699–700

    Article  Google Scholar 

  • Overzier C (1973) Das Klinefelter-Syndrom. Dtsch Ärzteblatt 47:3272

    Google Scholar 

  • Paulsen CA, Gordon DL, Carpenter RW (1968) Klinefelter syndrome and its variants: a hormonal and chromosomal study. Recent Prog Horm Res 24:321–353

    PubMed  CAS  Google Scholar 

  • Perwein E, Schill W-B (1982) Androgen dependent seminal plasma proteins demonstrated by micro disc gradient Polyacrylamide gel electrophoresis. Andrologia 14:219–222

    Article  PubMed  CAS  Google Scholar 

  • Raboch J (1957) Thirty-one men with female sex chromatin. J Clin Endocrinol Metab 17:1429–1439

    Article  PubMed  CAS  Google Scholar 

  • Raboch J, Bleha O (1960) Über ein echtes Klinefelter’sches Syndrom mit kompletter Spermiogenese. Endokrinologie 39:203–207

    PubMed  CAS  Google Scholar 

  • Raboch J, Homolka J (1961) Acid phosphatases in the ejaculate of men with disturbances of somatosexual development. Fertil Steril 12:368–374

    PubMed  CAS  Google Scholar 

  • Raboch J, Starka L, Neuwirth J (1971) Hormonal testicular activity in chromatin-positive men. Endokrinologie 58:425–431

    PubMed  CAS  Google Scholar 

  • Raboch J, Neuwirth J, Starka L (1975) Plasmatic testosterone values in 105 Klinefelters. Andrologia 7:77–83

    Article  PubMed  CAS  Google Scholar 

  • Saba P, Gambassi G, Novi AM, Luisi M (1969) Electron microscopy of the Leydig cells and hormone assays in Klinefelter’s syndrome. Endokrinologie 55:129

    PubMed  CAS  Google Scholar 

  • Schill W-B (1973) Acrosin activity in human spermatozoa: methodological investigations. Arch Dermatol Forsch 248:257–273

    PubMed  CAS  Google Scholar 

  • Schill W-B (1975) Die Bedeutung proteolytischer Spermaenzyme für die Fertilität. Hautarzt 26:514–523

    PubMed  CAS  Google Scholar 

  • Schill W-B (1976) Fructosebestimmung im Spermaplasma. Med Klin 71:1031–1041

    PubMed  CAS  Google Scholar 

  • Schill W-B, Dasilva M (1983) Results of spermatograms obtained close to conception. In: Schirren C, Holstein AF (eds) Advances of andrology, vol 8. IL Föhringer symposium: Diagnostic aspects of andrology. Grosse, Berlin Chicago, pp 27–36

    Google Scholar 

  • Schill W-B, Schumacher GFB (1972) Radial diffusion in gel for micro determination of enzymes. I. Muramidase, alpha-amylase, DNase I, RNase A, acid phosphatase and alkaline phosphatase. Analyt Biochem 46:502–533

    Article  PubMed  CAS  Google Scholar 

  • Schill W-B, Schumacher GFB (1973) Micro radial diffusion in gel methods for the quantitative assessment of soluble proteins in genital secretions. In: Blandau RJ, Moghissi K (eds) The biology of the cervix. University of Chicago Press, Chicago, pp 173–200

    Google Scholar 

  • Schill W-B, Rjosk H-K, Križić A (1980) Andrologische, biochemische und endokrinologische Untersuchungen bei subfertilen Männern während Kallikrein-Therapie. Hautarzt 31:191–197

    PubMed  CAS  Google Scholar 

  • Schill W-B, Jüngst D, Unterburger P, Braun S (1982) Combined hMG/hCG treatment in subfertile men with idiopathic normogonadotropic oligozoospermia. Int J Androl 5:467–477

    Article  PubMed  CAS  Google Scholar 

  • Schirren C (1982) Praktische Andrologie. Karger, Basel

    Google Scholar 

  • Segal JS, Nelson WO (1957) Developmental aspects of human hermaphrodism: the significance of sex chromatin patterns. J Clin Endocrinol Metab 17:676–690

    Article  PubMed  CAS  Google Scholar 

  • Siebenmann R (1958) Die Gonadendysgenesien: Klinefelter-Syndrom, Turnersyndrom und echter Hermaphroditismus. Virchows Arch [Pathol Anat] 331:417–440

    Article  CAS  Google Scholar 

  • Steinberger E, Smith KD, Perloff WH (1965) Spermatogenesis in Klinefelter’s syndrome. J Clin Endocrinol 25:1325–1330

    Article  CAS  Google Scholar 

  • Sterry W, Pfeiff B, Wieland W, Kurka M (1980) Zystische Akne und Klinokamptodaktylie bei Klinefelter-Syndrom (46 XY/47 XXY Mosaik) Z Hautkr 55:667–671

    PubMed  CAS  Google Scholar 

  • Tauber PF, Zaneveld LJD, Propping D, Schumacher GFB (1975) Components of human split ejaculates. I. Spermatozoa, fructose, immunoglobulins, albumin, lactoferrin, transferrin and other plasma proteins. J Reprod Fertil 43:249–267

    Article  PubMed  CAS  Google Scholar 

  • Tauber PF, Zaneveld LJD, Propping D, Schumacher GFB (1976) Components of human split ejaculates. II. Enzymes and proteinase inhibitors. J Reprod Fertil 46:165–171

    Article  PubMed  CAS  Google Scholar 

  • Tillinger K-G (1957) Testicular morphology. Acta Endocrinol [Suppl] 30:81–88

    Google Scholar 

  • Topper E, Dickerman Z, Prager-Lewin R, Kaufman H, Maimon Z, Laron Z (1982) Puberty in 24 patients with Klinefelter syndrome. Eur J Pediatr 139:8–12

    Article  PubMed  CAS  Google Scholar 

  • Umapathy E, Manimekalai S, Govindarajulu P (1980) Lipid pattern in split ejaculate and Klinefelter’s syndrome. Fertil Steril 33:294–296

    PubMed  CAS  Google Scholar 

  • Usadel KH, Leuschner U, Schwedes U, Schade C, Schoeffling K (1973) Über das Auftreten cholinerger Nervenfasern in den Tubuluswänden des Hodens bei primären Hypogonadismus (Klinefelter Syndrom, Kryptorchismus). Klin Wochenschr 51:1016–1023

    Article  PubMed  CAS  Google Scholar 

  • Warburg E (1963) A fertile patient with Klinefelter’s syndrome. Acta Endocrinol 43:12–25

    PubMed  CAS  Google Scholar 

  • Witschi E, Nelson WO, Segal SJ (1957) Genetic, developmental and hormonal aspects of gonadal dysgenesis and sex inversion in man. J Clin Endocrinol Metab 17:737–752

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dermatologische Klinik und Poliklinik, Universität München, Frauenlobstrasse 9–11, 8000, München 2, Germany

    W.-B. Schill, R. Strasser, F. Krassnigg, W. Müller-Ester & E. Fink

  2. Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgischen Universitätsklinik München, Nussbaumstrasse 20, 8000, München 2, Germany

    W.-B. Schill, R. Strasser, F. Krassnigg, W. Müller-Ester & E. Fink

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  1. W.-B. Schill
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  2. R. Strasser
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  3. F. Krassnigg
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  4. W. Müller-Ester
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  5. E. Fink
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  1. Dermatologische und Allergologische Abteilung, Städtisches Krankenhaus München-Schwabing, Kölner Platz 1, 8000, München 40, Germany

    Hans-Jürgen Bandmann , Reinhardt Breit  & Elmar Perwein ,  & 

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Schill, WB., Strasser, R., Krassnigg, F., Müller-Ester, W., Fink, E. (1984). Spermatological Investigations in Men with Klinefelter’s Syndrome. In: Bandmann, HJ., Breit, R., Perwein, E. (eds) Klinefelter’s Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69644-2_20

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  • DOI: https://doi.org/10.1007/978-3-642-69644-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13267-7

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