Klinefelter’s Syndrome and Leukemia: Coincidence or Association?
The interest in the presence of acquired chromosomal abnormalities in leukemia was brought about by the discovery of the Philadelphia chromosome in 1960. It was found in patients with chronic myeloid leukemia and was thought to be a deleted G-group chromosome. The introduction of the banding technique in 1970 provided the opportunity not only to recognize the individual human chromosomes but also to demonstrate structural abnormalities. The Philadelphia chromosome, for example, proved to be originated by a translocation between the chromosomes 9 and 22.
KeywordsChronic Myeloid Leukemia Acute Leukemia Polycythemia Vera Philadelphia Chromosome Cytostatic Treatment
Unable to display preview. Download preview PDF.
- Ruffié J, Colombiés P, Combes PF, Ducos J (1966) Leucémie lymphoblastique chez un porteur d’une anomalie congénitale complexe (type XXY probable). Bull Acad Natl Med Paris 150:342Google Scholar
- Sandberg AA (1980) The chromosomes in human cancer and leukemia. Elsevier, New York AmsterdamGoogle Scholar