Background, Recognition and Description of the Syndrome

  • H. F. Klinefelter
Conference paper


My fifth year of training in Dr. Warfield T. Longcope’s medical residency program at Johns Hopkins was spent as a traveling fellow at Harvard, working as a graduate assistant in medicine at the Massachusetts General Hospital. Many years later, I learned that this was made possible by a gift from my mother’s first cousin, Dr. Walter A. Baetjer, with whom I later entered practice in Baltimore.


Estrogen Adenoma Testosterone Assure Androgen 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barr ML, Bertram EG (1949) A morphological distinction between neurons of the male and female and the behavior of the nucleolar satellite during accelerated nucleo-protein synthesis. Nature 163:676–677PubMedCrossRefGoogle Scholar
  2. Bradbury JT, Bunge RG, Boccabella RA (1956) Chromatin test in Klinefelter’s syndrome. J Clin Endocrinol 16:689CrossRefGoogle Scholar
  3. Heller CG, Nelson WD (1945) Hyalinization of the seminiferous tubules associated with normal or failing Leydig cell function; discussion of relationship to eunuchoidism, gynecomastia, elevated gonadotropins, depressed 17-ketosteroids and estrogens. J Clin Endocrinol 5:1–12CrossRefGoogle Scholar
  4. Jacobs PA, Strong JA (1959) A case of human intersexuality having a possible XXY sex-determining mechanism. Nature 183:302–303PubMedCrossRefGoogle Scholar
  5. Klinefelter HF Jr, Reifenstein EC Jr, Albright F (1942) Syndrome characterized by gynecomastia, aspermatogenesis without a-leydigism and increased excretion of follicle-stimulating hormone. J Clin Endocrinol 2:615–627CrossRefGoogle Scholar
  6. Moore KL, Barr ML (1955) Smears from the oral mucosa in the detection of chromosomal sex. Lancet II:57–58CrossRefGoogle Scholar
  7. Plunkett ER, Barr ML (1956) Congenital testicular hypoplasia, Anat Rec 124:348Google Scholar
  8. Riis P, Johnsen SG, Mosbech J (1956) Letter to the Editor. Lancet I:962–963CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • H. F. Klinefelter
    • 1
  1. 1.BaltimoreUSA

Personalised recommendations