Skip to main content

Prinzipien der Immuntherapie

  • Chapter
Chirurgische Onkologie

Part of the book series: Die Praxis der Chirurgie ((PRAXCHIR))

  • 39 Accesses

Zusammenfassung

Die Immuntherapie maligner Tumoren resultiert aus der Vorstellung, daß das Auswachsen neoplastischer Zeilklone im Organismus durch einen Defekt in der Immunüberwachung ermöglicht wird. Durch eine spezifische oder unspezifische Stimulation immunologischer Abwehrmechanismen, etwa der Antikörperproduktion oder der zeilvermittelten Zytotoxizität, müßte daher eine Vernichtung bzw. Wachstumsbegrenzung von Tumorzellen möglich sein.

Mit Unterstützung durch die DFG, SFB 118

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Amery WK (1980) Adjuvant levamisole in the treatment of patients with resectable lung cancer. Ann Clin Res [Suppl 27] 12:1–83

    Google Scholar 

  • Anthony HM (1981) The Yorkshire trial of adjuvant therapy with levamisole in surgical lung cancer. In: Terry WD, Rosenberg SA (eds) Immunotherapy of human cancer. Elsevier, New York

    Google Scholar 

  • Beutler E, McMillan R, Spruce W (1982) The role of bone marrow transplantation in the treatment for acute leukemia in remission. Blood 59:1115–1127

    PubMed  CAS  Google Scholar 

  • Bier J, Rapp HJ, Borsos T, Zbar B, Kleinschuster S, Wagner H, Röllinghoff M (1981) Randomized clinical study on intratumoral BCG-cell wall preparation (CWP) therapy in patients with squamous cell carcinoma in the head and neck region. Cancer Immunol Immunother 12:71–79

    Article  Google Scholar 

  • Borden EC, Davis TE, Crowley JJ, Wolberg WH, Groveman D (1981) Interim analysis of a trial of levamisole and 5-fluorouracil in metastatic colorectal carcinoma. In: Terry WD, Rosenberg SA (eds) Immunotherapie of human cancer. Elsevier, New York

    Google Scholar 

  • Brosman SA (1982) Experience with bacillus Calmette-Gue-rin in patients with superficial bladder cander. J Urol 128:27–31

    PubMed  CAS  Google Scholar 

  • Busch W (1868) Verhandlungen ärztlicher Gesellschaften. Klin Wochenschr 5:137–138

    Google Scholar 

  • Cohen MH, Chretien B, Ihde DC et al. (1979) Thymosin fraction V and intensive combination chemotherapy. Prolonging the survival of patients with small-cell lung cancer. JAMA 241:1813–1815

    Article  PubMed  CAS  Google Scholar 

  • Coley WB (1891) Contributions to the knowledge of sarcoma. Ann Surg 14:199–220

    Article  PubMed  CAS  Google Scholar 

  • Diamond BA, Yelton DE, Scharff MD (1981) Monoclonal antibodies. A new technology for producing serologic reagents. N Engl J Med 304:134–1349

    Article  Google Scholar 

  • Fefer A, Cheever MA, Thomas ED et al. (1981) Bone marrow transplantation for refractory acute leukemia in 34 patients with identical twins. Blood 57:421–430

    PubMed  CAS  Google Scholar 

  • Gallo RC, Wong-Staal F (1982) Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis. Blood 60:545–557

    PubMed  CAS  Google Scholar 

  • Herberman RB (1981) Natural killer (NK) cells and their possible role in resistance against disease. Clin Immunol Rev 1:1–65

    Article  PubMed  CAS  Google Scholar 

  • Hersh EM, Quesada J, Murphy SG, Gutterman JU, Hutchins RD (1982) Evaluation of therapy with methanol extraction residue of BCG (MER). Cancer Immunol Im-munother 14:4–9

    CAS  Google Scholar 

  • Kirkwood JM, Ernstoff MS (1984) Interferons in the treatment of human cancer. J Clin Oncol 2:336–352

    PubMed  CAS  Google Scholar 

  • Krolick KA, Yvan D, Vitetta ES (1981) Specific killing of a human breast carcinoma cell line by a monoclonal antibody coupled to the A-chain of ricin. Cancer Immunol Immunother 12:39–41

    Article  Google Scholar 

  • Lamm DL, Thor DE, Stogdill VD, Radwin HM (1982) Bladder cander. Immunotherapy. J Urol 128:941–935

    Google Scholar 

  • Levin AS, Byers VS, Fudenberg HH, Wybran J, Hackett AJ, Johnston JO, Spitlér LE (1975) Osteogenic sarcoma. Immunologic parameters before and during immunotherapy with tumor-specific transfer factor. J Clin Invest 55:487–499

    Article  PubMed  CAS  Google Scholar 

  • Lotze MT, Line BR, Mathisen DJ, Rosenberg SA (1980) The in vivo distribution of autologous human and murine lymphoid cells grown in T-cell growth factor (TCGF): Implications for the adoptive immunotherapy of tumors. J Immunol 125:1487–1493

    PubMed  CAS  Google Scholar 

  • Mastrangelo MJ, Rosenberg SA, Baker AR, Katz HR (1982) Cutaneous melanoma. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology. Lippincott, Philadelphia, pp 1124–1170

    Google Scholar 

  • Maver C, Kausel HW, Lininger L, McKneally MF (1982) Intrapleural BCG immunotherapy of lung cancer patients. Recent Results Cancer Res 80:227–231

    PubMed  CAS  Google Scholar 

  • McGee JOD, Woods JC, Ashall F, Bramwell ME, Harris H (1982) A new marker for human cancer cells. 2. Immunohistochemical detection of the Ca antigen in human tissues with the Cal antibody. Lancet 11:7–10

    Article  Google Scholar 

  • Miller RA, Levy R (1981) Response of cutaneous T cell lymphoma to therapy with hybridoma monoclonal antibody. Lancet 11:226–230

    Article  Google Scholar 

  • Miller RA, Maloney DG, Warnke R, Levy R (1982) Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med 306:517–522

    Article  PubMed  CAS  Google Scholar 

  • Montie JE, Bukowski RM, James RE, Straffon RA, Stewart BH (1982) A critical review of immunotherapy of disseminated renal adenocarcinoma. J Surg Oncol 21:5–8

    Article  PubMed  CAS  Google Scholar 

  • Morales A, Eidinger D, Bruce AW (1976) Intracavitary bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J Urol 116:180–184

    PubMed  CAS  Google Scholar 

  • O’Reilly RJ (1983) Allogeneic bone marrow transplantation: Current status and future directions. Blood 62:941–964

    PubMed  Google Scholar 

  • Pinsky CM, Hilal EY, Wanebo HJ, Strong EW, Oettgen HF (1981) Randomized trial of levamisole in patients with squamous cell carcinoma of head and neck. In: Terry WD, Rosenberg SA (eds) Immunotherapy of human cancer. Elsevier, New York

    Google Scholar 

  • Ritz J, Pesando JM, Sallan SE, Clavell LA, Notis-McCo-narty J, Rosenthal P, Schlossman SF (1981) Serotherapy of acute lymphoblastic leukemia with monoclonal antibody. Blood 58:141–152

    PubMed  CAS  Google Scholar 

  • Rosenberg SA, Rapp HJ (1976) Intralesional immunotherapy of melanoma with BCG. Med Clin North Am 60:419–430

    PubMed  CAS  Google Scholar 

  • Sears HF, Mattis J, Herlyn D et al. (1982) Phase 1 clinical trial of monoclonal antibody in treatment of gastrointestinal tumors. Lancet I:763–765

    Google Scholar 

  • Shapiro A, Kadmon D, Catalona WJ, Ratliff TL (1982) Immunotherapy of superficial bladder cancer. J Urol 128:891–894

    PubMed  CAS  Google Scholar 

  • Sherwin SA, Knost JA, Fein S et al. (1982) A multiple-dose phase I trial of recombinant leukocyte A interferon in cancer patients. JAMA 284:2461–2466

    Article  Google Scholar 

  • Slease RB, Strong DM, Gawith KE, Bonnard GD (1981) Clinical effects of infusions into chimpanzees of primed autologous cultured T-cells. J Natl Cancer Inst 67:489–493

    PubMed  CAS  Google Scholar 

  • Smith RB, de Kernon J, Lincoln B, Skinner DG, Kaufmann JJ (1978) Preliminary report of the use of levamisole in the treatment of bladder cancer. Cancer Treat Rep 2:1709–1713

    Google Scholar 

  • Spitler LE, Sagebiel R (1980) A randomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma. N Engl J Med 303:1143–1147

    Article  PubMed  CAS  Google Scholar 

  • Stiehm ER, Kronenberg LH, Rosenblatt HM, Bryson Y, Merigan TC (1982) Interferon. Immunobiology and clinical significance. Ann Intern Med 96:80–93

    PubMed  CAS  Google Scholar 

  • Szmuness W (1978) Hepatocellular carcinoma and the hepatitis B virus: Evidence for a causal association. Prog Med Virol 24:40–69

    PubMed  CAS  Google Scholar 

  • Terry WD, Hodes RJ (1982) Immunotherapy. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology. Lippincott, Philadelphia, pp 1788–1810

    Google Scholar 

  • Thomas ED (1983) Marrow transplantation for malignant diseases. J Clin Oncol 1:517–531

    PubMed  CAS  Google Scholar 

  • Verhaegen H, de Crée J, de Cock W, Verhaegen-Declercq ML (1981) Levamisole in patients with colorectal cancer. In: Terry WD, Rosenberg SA (eds) Immunotherapy of human cancer. Elsevier, New York

    Google Scholar 

  • Veronesi U, Adamus J, Aubert C et al. (1982) A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma. N Engl J Med 307:913–916

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Gramatzki, M., Kalden, J.R. (1986). Prinzipien der Immuntherapie. In: Gall, F.P., Hermanek, P., Tonak, J. (eds) Chirurgische Onkologie. Die Praxis der Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69600-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69600-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69601-5

  • Online ISBN: 978-3-642-69600-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics