Impaired Control of Appetite for Carbohydrates in Some Patients with Eating Disorders: Treatment with Pharmacologic Agents
The ability of animals or humans to control their consumption of energy in proportion to energy use has been recognized for some time (Kissileff and Van Itallie 1982). Less attention has been given to their ability to regulate intake of specific macronutrients. Although the roles of protein, carbohydrate, and fat in the body have been described and the amount of these nutrients needed daily has been established, consumption of foods has largely been regarded as motivated solely by the individual’s need for energy. For example, if an animal given rat chow diluted 50% with fat (so that it now contains only half as much protein or carbohydrate per gram), elects to eat abnormally large amounts of this food, the overconsumption is generally interpreted as reflecting an inability to control energy intake in the presence of a high-fat diet (Kissileff and Van Itallie 1982). The possibility that the animal is eating more of the food in order to consume a desired amount of protein or carbohydrate by consuming quantities large enough to compensate for the dilution of one or the other nutrient is usually not considered.
KeywordsPlacebo Obesity Sucrose Carbohydrate Serotonin
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