Skip to main content
SpringerLink
Log in

Endocrine Function in Magersucht Disorders

  • Conference paper
The Psychobiology of Anorexia Nervosa

Abstract

Professor Ploog has posed three important questions for consideration at our symposium. These questions may be paraphrased as follows:

  1. 1.

    Are all the physical manifestations of anorexia nervosa a direct result of undernutrition, or are other major factors also involved?

  2. 2.

    If undernutrition is the prime cause, how does its presence bring about the physical symptoms that characterize the illness?

  3. 3.

    Is knowledge of the pathogenesis of the physical changes in anorexia nervosa merely a matter of academic interest? Or is such knowledge of practical significance, substantially increasing our understanding of the illness?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham SF, Beumont PJV, Fraser IS, Llewellyn-Jones D (1982) Body weight, exercise and menstrual status among ballet dancers in training. Br J Obstet Gynaecol 89: 507–510

    Article  CAS  PubMed  Google Scholar 

  • American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd ed. American Psychiatric Association, Washington

    Google Scholar 

  • Beardwood CJC (1974) Relationship between body weight and gonadotrophin excretion in anorexia nervosa and obesity. S Afr Med J 48: 53–58

    CAS  PubMed  Google Scholar 

  • Beumont PJV (1977) Further categorization of patients with anorexia nervosa. Aust N Z J Psychiatry 11: 223–226

    Article  CAS  PubMed  Google Scholar 

  • Beumont PJV, Abraham SF (1981) Continuous infusion of luteinizing hormone releasing hormone ( LHRH) in patients with anorexia nervosa. Psychol Med 11: 477–484

    Google Scholar 

  • Beumont PJV, Carr PJ, Gelder MG (1973) Plasma levels of luteinizing hormone and of immunoreactive oestrogens (oestradiol) in anorexia nervosa: response to clomiphene citrate. Psychol Med 3: 495–501

    Article  CAS  PubMed  Google Scholar 

  • Beumont PJV, Abraham SF, Argall WJ (1979) Variables of onset in anorexia nervosa. In: Obiols J, Ballus C, Gonzales Monclus E, Pujol J (eds) Biological psychiatry today. Elsevier North-Holland Biomedical Press, Amsterdam Oxford New York, pp 597–601

    Google Scholar 

  • Beumont PJV, Corker CS, Friesen HG, Gelder MG, Harris GW, Kolakowska T, MacKinnon PCB, Mandelbrote BM, Marshall J, Murray MAF, Wiles DH (1974) The effect of phenothiazines on endocrine function. Br J Psychiatry 124: 413–430

    Article  CAS  PubMed  Google Scholar 

  • Beumont PJV, George GCW, Pimstone BL, Binik AI (1976a) The pituitary response to hypothalamic releasing hormones in patients with anorexia nervosa. J Clin Endocrinol Metabol 43: 487–496

    Article  CAS  Google Scholar 

  • Beumont PJV, George GC, Smart DE (1976b) ‘Dieters’ and ‘vomiters and purgers’ in anorexia nervosa. Psychol Med 6:617–622

    Google Scholar 

  • Beumont PJV, Chambers TL, Rouse L, Abraham SF (1981) Diet composition and nutritional knowledge of patients with anorexia nervosa. J Hum Nutr 35: 265–273

    Google Scholar 

  • Brown GM, Garfinkel PE, Jeuniewic N, Moldofsky H, Stancer HC (1977) Endocrine profiles in anorexia nervosa. In: Vigersky RA (ed) Anorexia nervosa. Raven, New York, pp 123–136

    Google Scholar 

  • Casper RC, Davis JM, Pandey GN (1977) The effect of nutritional status and weight changes on hypothalamic function tests in anorexia nervosa. In: Vigersky RA (ed) Anorexia nervosa. Raven, New York, pp 137–147

    Google Scholar 

  • Chopra IJ, Chopra U, Smith SR, Reza M, Solomon DH (1975) Reciprocal changes in serum concentration of 3,3′,5-triiodothyronine (reverse T3) and 3,5′, 3′-triiodothyronine (T3) in systemic illness. J Clin Endocrinol Metabol 41: 1043–1049

    Article  CAS  Google Scholar 

  • Crisp AH (1967) Anorexia nervosa. Br J Hosp Med 1: 713–718

    Google Scholar 

  • Decourt J (1953) Die anorexia nervosa: Psycho-endokrine Kachexie der Reifungszeit. Dtsch Med Wochenschr 78: 1619–1622

    Article  CAS  PubMed  Google Scholar 

  • Escamilla RF, Lisser H (1942) Simmonds’ disease. J Clin Endocrinol Metabol 2: 65–96

    Article  Google Scholar 

  • Feighner JP, Robins E, Guze SB, Woodruff RA, Jr Winokur G, Munoz R (1972) Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26: 57–63

    Article  CAS  PubMed  Google Scholar 

  • Frankel RJ, Jenkens JS (1975) Hypothalamic-pituitary function in anorexia nervosa. Acta Endocrinol (Kbh) 78: 209–221

    CAS  Google Scholar 

  • Frisch RE (1977) Food intake, fatness and reproductive ability. In: Vigersky R (ed) Anorexia nervosa. Raven, New York, pp 149–162

    Google Scholar 

  • Guevara A, Luria MH, Wieland RE (1970) Serum gonadotrophin levels during medical stress. Metabolism 19: 79–83

    Article  CAS  PubMed  Google Scholar 

  • Gull WW (1873) Anorexia hysterica (apepsia hysterica). Br Med J 2: 257–528

    Google Scholar 

  • Halmi KA (1976) Selective pituitary deficiency in anorexia nervosa. In: Sachar E (ed) Hormones, behaviour and psychopathology. Raven, New York, pp 285–290

    Google Scholar 

  • Jeuniewic N, Brown GM, Garfinkel PE, Moldofsky H (1978) Hypothalamic function as related to body weight and body fat in anorexia nervosa. Psychosom Med 40: 187–198

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim EA, Howland BE (1972) Effect of starvation on pituitary and serum FSH and LH following ovarectomy in the rat. Can J Physiol Pharmacol 50: 768–773

    CAS  PubMed  Google Scholar 

  • Kaufman MR, Heiman M (1964) Evolution of psychosomatic concepts. Anorexia nervosa: a paradigm. International Universities Press, New York

    Google Scholar 

  • Lancet (1979) Anorexia nervosa: to investigate or to treat. Lancet 2: 563–564

    Google Scholar 

  • Lasegue C (1873) De l’anorexie hysterique. Reprinted (1964) in: Kaufman MR, Herman M (eds) Evolution of a psychosomatic concept: anorexia nervosa. International Universities Press, New York, pp 141–155

    Google Scholar 

  • Malaisse WJ, Malaisse-Lagae F, Wright PH (1967) Effect of fasting on insulin secretion in the rat. Am J Physiol 213: 843–848

    CAS  PubMed  Google Scholar 

  • Malina RM, Spirduso WW, Tate C, Baylor AM (1978) Age at menarche and selected menstrual characteristics in athletes. Med Sei Sports 10: 218–222

    CAS  Google Scholar 

  • Marks V, Howorth N, Greenwood DFC (1965) Plasma growth-hormone levels in chronic starvation in man. Nature 208: 686–687

    Article  CAS  Google Scholar 

  • Marshall JC, Fräser TG (1971) Amenorrhoea in anorexia nervosa: assessment and treatment with clomiphene citrate. Br Med J 4: 590–592

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Meites J, Reed JO (1949) Effects of restricted food intake in intact and ovarectomized rats on pituitary lactogen and gonadotrophin. Proc Soc Exp Biol Med 70: 513–516

    Article  CAS  PubMed  Google Scholar 

  • Moshang T, Utiger RD (1977) Low triiodothyronine euthyroidism in anorexia nervosa. In: Vigersky RA (ed) Anorexia nervosa. Raven, New York, pp 263–270

    Google Scholar 

  • Naish JM (1979) Problems of deception in medical practice. Lancet 2: 139–142

    Article  CAS  PubMed  Google Scholar 

  • Nilius SJ, Fries H, Wide L (1975) Successful induction of follicular maturation and ovulation by prolonged treatment with LH-releasing hormone in women with anorexia nervosa. Am J Obstet Gynecol 122: 921–928

    Google Scholar 

  • Pasteeis JL, Franchimont P (1976) The production of FSH by cell cultures of fetal pituitary. In: Hubinat P (ed) Progress in reproductive endocrinology. Karger, Basel

    Google Scholar 

  • Rakoff AE (1968) Endocrine mechanisms in psychogenic amenorrhoea. In: Michael RP (ed) Endocrinology and human behaviour. Oxford University Press, London, pp 139–160

    Google Scholar 

  • Russell GFM (1970) Anorexia nervosa: its identity as an illness and its treatment. In: Price DH (ed) Modern trends in psychological medicine. Butterworths, London, pp 131–164

    Google Scholar 

  • Russell GFM (1972) Psychological and nutritional factors in disturbances of menstrual function and ovulation. Postgrad Med J 48: 10–13

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Russell GFM (1977) The present status of anorexia nervosa (editorial). Psychol Med 7: 363–367

    Article  CAS  PubMed  Google Scholar 

  • Russell GFM (1979) Bulimia nervosa, an ominous variant of anorexia nervosa. Psychol Med 9: 429–448

    Article  CAS  PubMed  Google Scholar 

  • Sheehan HL, Summers VK (1948) The syndrome of hypopituitarism. Q J Med 18: 319–398

    Google Scholar 

  • Sheldon JH (1939) Anorexia nervosa. Proc R Soc Med 32: 738–740

    Google Scholar 

  • Sherman BM, Halmi KA, Zamudio R (1975) LH and FSH response to gonadotrophin-releasing hormone in anorexia nervosa: effect of nutritional rehabilitation. J Clin Endocrinol Metabol 41: 131–142

    Article  Google Scholar 

  • Simmonds M (1918) Atrophie des Hypophysisvorderlappen und hypophysäre Kachexie. D Med Wochenschr 44: 852–854

    Article  Google Scholar 

  • Smart DE, Beumont PJV, George GCW (1976) Some personality characteristics of patients with anorexia nervosa. Br J Psychiatry 128: 57–60

    Article  CAS  PubMed  Google Scholar 

  • Smith NJ (1980) Excessive weight loss and food aversion in athletes simulating anorexia nervosa. Pediatrics 66: 139–142

    CAS  PubMed  Google Scholar 

  • Soman VR, Koivisto VA, Deibert D, Feiig P, Defronzo RA (1979) Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med 301: 1200–1204

    Article  CAS  PubMed  Google Scholar 

  • Vagenukis AG (1977) Thyroid hormone metabolism in prolonged experimental starvation in man. In: Vigersky RA (ed) Anorexia nervosa. Raven, New York, pp 243–254

    Google Scholar 

  • Wakeling A, de Souza VA, Beardwood CJ (1977) Assessment of the negative and positive feedback effects of administered oestrogen on gonadotrophin release in patients with anorexia nervosa. Psychol Med 7: 397–405

    CAS  Google Scholar 

  • Warren MP (1977) Weight loss and responsiveness to LH-RH. In: Vigersky RA (ed) Anorexia nervosa. Raven, New York, pp 189–198

    Google Scholar 

  • Yates A, Leehey K, Shisslak CM (1983) Running — an analogue of anorexia? N Engl J Med 308: 251–255

    Article  CAS  PubMed  Google Scholar 

  • Yen SSC (1977) Neuroendocrine aspects of the regulation of cyclic gonadotrophin release in women. In: Martini L, Besser GM (eds) Clinical endocrinology. Academic, New York, pp 175–196

    Google Scholar 

  • Yoshimoto Y, Moridera K, Imura H (1975) Restoration of normal pituitary gonadotrophin reserve by administration of luteinising hormone releasing in patients with hypogonadotropic hypogonadism. N Engl J Med 292: 242–245

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Royal Prince Alfred Hospital, The University of Sydney, Camperdown, 2006, NSW, Australia

    P. J. V. Beumont

Authors
  1. P. J. V. Beumont
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Psychiatrie, Kraepelinstraße 10, D-8000, München 40, Germany

    Karl Martin Pirke  & Detlev Ploog  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Beumont, P.J.V. (1984). Endocrine Function in Magersucht Disorders. In: Pirke, K.M., Ploog, D. (eds) The Psychobiology of Anorexia Nervosa. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69594-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69594-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13196-0

  • Online ISBN: 978-3-642-69594-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation