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Early and Late Proteins of Adenovirus Type 12: Translation Mapping with RNA Isolated from Infected and Transformed Cells

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Book cover The Molecular Biology of Adenoviruses 3

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 111))

Abstract

Human adenoviruses, especially types 2, 5, and 12, have been the subject of extensive studies because of their ability to cause morphological transformation of cultured cells or, in the case of Ad12, to induce tumors in animals. On the other hand, the adenovirus/cell system has clearly established itself as a useful tool for studying gene expression in mammalian cells. Several precise chemical tools for studying the adenovirus genome have become available in recent years; these include methods for separating restriction enzyme fragments of viral DNA and hybridization methods for detecting viral RNAs. The application of recombinant DNA technology has yielded precise information about the genomic and the messenger RNA sequences expressed by different regions of the genome. Most but not all of the proteins encoded by the adenovirus genome have been characterized by structure, but the function of the proteins is still unresolved.

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  1. Institute of Genetics, University of Cologne, D-5000, Cologne, Germany

    H. Esche, M. Reuther & K. Schughart

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  1. H. Esche
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  2. M. Reuther
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  1. Institut für Genetik der Universität zu Köln, Weyertal 121, D-5000, Köln 41, Germany

    Walter Doerfler

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Esche, H., Reuther, M., Schughart, K. (1984). Early and Late Proteins of Adenovirus Type 12: Translation Mapping with RNA Isolated from Infected and Transformed Cells. In: Doerfler, W. (eds) The Molecular Biology of Adenoviruses 3. Current Topics in Microbiology and Immunology, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69549-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-69549-0_4

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