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Clinical Pharmacology of Antianginal Drugs pp 97–115Cite as

Pharmacodynamic Principles of Action of Antianginal Drugs

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 76))

Abstract

Actions of substances on biological systems are termed pharmacodynamic when they are considered to counteract a particular disease of the underlying pathological disorder. It follows that throughout the ages the pharmacodynamic principles of action have been directly dependent on the prevailing concepts of pathology and developed in close conjunction with advances in this field. The clinical pharmacological testing of preparations on patients on the basis of these considerations frequently failed to result in any clinical efficacy, not least because the pathological concept of the disease in question proved to be incorrect. The mutual interdependence of pharmacodynamic principles of action and fundamental pathophysiological concepts of the causes and nature of specific disturbances has been manifest in coronary disease with greater clarity than in any other disease.

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Kraupp, O. (1985). Pharmacodynamic Principles of Action of Antianginal Drugs. In: Abshagen, U. (eds) Clinical Pharmacology of Antianginal Drugs. Handbook of Experimental Pharmacology, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69524-7_3

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